This study explored the in vivo wound healing potential of Vitis vinifera seed extract using an excision model with focus on molecular targets including TGFBR1, VEGF, TNF-α, and IL-1β. The results revealed that V. enhanced closure rates (p < 0.001), elevated TGF-β VEGF levels, significantly downregulated TNF-α IL-1β levels comparison to Mebo®-treated group. phenotypical were supported by biochemical histopathological findings. Phytochemical investigation yielded a total 36 compounds...

Malaria is one of the most important infectious diseases worldwide. The causative severe forms malaria, Plasmodium falciparum, has developed resistances against all available antimalarial drugs. In present study, phytochemical investigation green seaweed Halimeda macroloba afforded two new compounds 1-2, along with 4 known ones 3-6. structures had been confirmed using 1& 2D-NMR and HRESIMS analyses. Extensive machine-learning-supported virtual-screening suggested cytochrome-C enzyme as a...

Mucormycosis, a life‐threatening fungal infection caused by Mucorales, affects immunocompromised patients, especially SARS‐CoV‐2 ones. Existing antifungal therapies, like amphotericin B, have serious health risks. The current study reviews the literature regarding an overview of SARS‐CoV‐2‐associated mucormycosis, along with different terpenes from diverse edible sources such as basil, ginger, and clove, which are detected till June 2024. potential collected terpenes, their classifications,...

Scabies is an invasive skin condition caused by Sarcoptes scabiei mites. The present study investigates the antiscabies potential of coconut seed extract (CSE) in rabbits. GC-MS analysis oil identified 17 known compounds, while CSE phytochemical investigation afforded 4 ones. topical application improved all signs infection, and improvement started 3 days post application. However, vitro 99% mortality mites 1 day Histopathological examination revealed absence inflammatory infiltration...

Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial which promotes inflammation, stiffness, swelling, cartilage degradation and further bone destruction.

SARS-COVID-2 has recently been one of the most life-threatening problems which urgently needs new therapeutic antiviral agents, especially those herbal origin.The study aimed to load acaciin (ACA) into self-assembled nanofibers (NFs) followed by investigating their possible effect against bovine coronavirus (BCV) as a surrogate model for SARS-COV-2.ACA was identified using 1H-NMR and DEPT-Q 13C-NMR spectroscopy, molecular docking performed Autodock 4 modification traditional solvent...

The present study aimed to detect the bioactive metabolites from Ocimum forskolei aerial parts which are responsible for antiulcer activity of total ethanol extract (TEE) as well different fractions (petroleum ether, dichloromethane, ethyl acetate and aqueous). Six flavonoids were isolated dichloromethane fraction was most potent; with an ulcer index value 2.67 ± 2.18*** % inhibition 97.7%; following a bioassay-guided fractionation. subjected molecular docking analysis in attempt explain...

Impaired skin wound healing is still a major challenge, especially with immunocompromised patients who express delayed and are susceptible to infections. Injection of rat-derived bone marrow mesenchymal stem cells (BMMSCs) via the tail vein accelerates cutaneous their paracrine activity. The present work aimed investigate combined wound-healing potential BMMSCs Halimeda macroloba algae extract in rats. High-resolution liquid chromatography-mass spectrometry (HR-LC-MS) investigation revealed...

Ocimum forskolei (Habak), Lamiaceae, is an endemic species from Yemen and KSA; where our present study was aimed at investigating the Metabolic profiling coupled with LCHR-MS analysis of dichloromethane fraction aerial parts that plant a special emphasis on ursolic acid as major predominating compound this fraction. Histopathological evaluation in different doses against indomethacin-induced ulcers rats revealed highly significant dose dependent protection. With level 50 mg/kg b.w., Ursolic...

The novel strain of human coronavirus, emerged in December 2019, which has been designated as SARS-CoV-2, causes a severe acute respiratory syndrome. Since then, it arisen serious threat to the world public health. no approved vaccines or drugs found efficiently stop virulent spread virus, progressive inquiries targeting these viruses are urgently needed, especially those from plant sources. Metabolic profiling using LC-HR-ESI-MS butanol extract Ocimum menthiifolium (Lamiaceae) aerial parts...

Wound healing, one of the most intricate and dynamic processes body, maintains skin integrity following trauma. One main issues that still exists is impaired wound particularly for immunosuppressed patients. Recently, natural products from marine environments have been employed in wound-repairing activities. This work investigates mesenchymal stem cells combined capacity bone marrow (BMMSC) healing Cystoseira sp. Algae extract rats. High-resolution liquid chromatography / MS investigation...

The current study investigated the scabicidal potential of Egyptian mandarin peel oil (Citrus reticulata Blanco, F. Rutaceae) against sarcoptic mange-in-rabbits. Analysis oil's GC-MS identified a total 20 compounds, accounting for 98.91% all compounds found. Mandarin topical application improved signs infection, causing effect three days later, whereas in vitro caused complete mite mortality one day later. In comparison to ivermectin, histopathological analysis showed that epidermis'...

The present study aimed to detect the bioactive metabolites from Ocimum forskolei aerial parts which are responsible for local anaesthetic activity of ethyl acetate fraction. Following a bioassay-guided fractionation, twelve compounds were dereplicated fraction was most potent one with mean onset action (1.43 ± 0.07****) min compared tetracaine as positive control (1.37 min. These compounds, along seven other (isolated by diverse chromatographic techniques) subjected molecular docking...

Otomycosis is a serious superficial mycotic infection of the outer ear canal caused by some pathogenic species Candida and Aspergillus. The remains challenge to clinicians owing incomplete efficacy market-available antifungal agents high recurrence rates. Moringa oleifera leaf ethanol extract showed against albicans SC5314, compared Nystatin® as reference with MIC values 7 718.33 μg ml-1, respectively. was mixed lecithin chitosan give core/shell giant nanoparticles, good zeta potential...

Delayed healing of chronic wounds results in amputation and mortality rates serious cases. The present study examines the merged wound-restorative efficacy injectable bone marrow-derived mesenchymal stem cells (BMMSCs) topical Callyspongia sp. extract immunocompromised rats. HR-LC-MS analysis tentatively identified twenty-nine compounds (1-29) highlighted its richness fatty acids terpenoids, known for their wound regenerating efficacies. closure was greatly prominent BMMSCs/Callyspongia...

LC-HR-MS-coupled metabolic profiling of the methanol extracts from different parts Syzygium cumini (L.), which was extensively identified via DNA fingerprinting, led to dereplication 24 compounds. Cytotoxic investigation highlighted both as most potent, against MCF-7 and MDA-231 Cell lines, with IC50 value 5.86 ± 0.63 µg/ml HCT -116 cell line, 1.24 0.09 µg/ml, respectively. A molecular docking study performed on dereplicated compounds, myricetin-3-glucoside (7), myricitrin (12), reynoutrin...

The current study aimed to investigate the anti-epileptic potential of ethanol extract and its different fractions from Lamiaceous plant, Ocimum menthiifolium. results revealed that aqueous fraction with latest onset myoclonic convulsions (1095 ± 45**** s) was most biologically active one. This followed by LC-HR-MS-coupled metabolic profiling which led dereplication 8 compounds fraction. A molecular docking performed on dereplicated discover main responsible ones for activity. highlighted...

The present study aimed to determine the lethal dose {LD50} using acute toxicity models and evaluate anti-inflammatory activity of total ethanolic extract (TEE) different fractions Ocimum forskolei Benth. aerial parts (leaves stems) following carrageenan-induced paw edema model in rats. results obtained revealed that LD50 value TEE was 8 g/kg body weight, while showed a significant decrease edema, especially aqueous fraction treated group with % inhibition (40.77 %, P < 0.001) comparison...

<title>Abstract</title> Sarcoptic mange, also referred to as scabies in humans, is a highly contagious skin condition caused by the burrowing mite Sarcoptes scabiei (Astigmata: Sarcoptinae). This parasitic disease significantly affects livestock production and poses substantial threat both animal human health. The current treatment methods primarily involve synthetic acaricides like permethrin ivermectin. However, these medications have several limitations, including lack of ovicidal...