A5091596289- Drug-Induced Hepatotoxicity and Protection
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and biological activity
- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Sirtuins and Resveratrol in Medicine
- Synthesis and Biological Evaluation
- Regulation of Appetite and Obesity
- Helicobacter pylori-related gastroenterology studies
- Acute Kidney Injury Research
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Ovarian function and disorders
- Liver Disease and Transplantation
- Antibiotic Use and Resistance
- Infectious Encephalopathies and Encephalitis
- Fatty Acid Research and Health
- Bioactive Compounds and Antitumor Agents
- Neurological Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Wound Healing and Treatments
Minia University
2016-2024
University of Calgary
2013-2022
The structure-based design introduced indoles as an essential motif in designing new selective estrogen receptor modulators employed for treating breast cancer. Therefore, here, a series of synthesized vanillin-substituted indolin-2-ones were screened against the NCI-60 cancer cell panel followed by vivo, vitro, and silico studies. Physicochemical parameters evaluated with HPLC SwissADME tools. compounds demonstrated promising anti-cancer activity MCF-7 line (GI = 6-63%). compound highest...
Antibiotic misuse, either by patients or healthcare professionals, is one of the major contributing factors to antimicrobial resistance. In many Middle Eastern countries including Egypt, there are no strict regulations regarding antibiotic dispensing community pharmacies. this study, we examined patterns in Egyptian About 150 pharmacies were randomly chosen using convenience sampling from five most populous urban districts Minia Governorate Egypt. Two simulated patient (SP) scenarios viral...
Benign prostatic hyperplasia (BPH) is the most common urogenital condition in aging males, while inflammation and tissue proliferation constitute main pathophysiological factors. The adverse effects of currently available BPH medications limit patient compliance. We tested protective effect aescin against development rats.A total 18 male Wistar rats were divided into 3 groups: control (sesame oil 1 mL/kg, s.c.); (testosterone oenanthate mg/kg, s.c., sesame oil), BPH-aescin s.c. + 10...
Dihydromyricetin (DHM), a natural flavonoid isolated from vine tea with anti-inflammatory activity was evaluated for its ability to prevent vascular endothelial dysfunction caused by hyperglycaemia. Vasoconstrictor (phenylephrine-PE) and vasodilator (acetylcholine-ACh) responses were monitored female rat aorta rings maintained in bioassay organ bath 3 h at 37 °C either low (LG: 10 mM) or high (HG: 40 mM, mimic hyperglycaemia) glucose-Krebs buffer the absence presence of 50 µM DHM. Tissues...
Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and increases the risk of death. Inflammation oxidative stress are main mediators pathophysiology sepsis. Therefore, we investigated role menthol, natural antioxidant, against sepsis-induced liver injury female Wistar rats. Sepsis was induced by cecal ligation puncture (CLP). Menthol (100 mg/kg) given intragastric 2 h after CLP. Blood samples tissues were collected 24 surgery. significantly (p < 0.05)...
Inflammation and oxidative stress play a major role in the development of sepsis its associated complications, leading to multiple organ failure death. The lungs, liver, kidneys are among early affected organs correlated with mortality sepsis. Alpha-chymotrypsin (α-ch) is serine protease that exerts anti-inflammatory, anti-edematous, anti-oxidant properties.This study was undertaken elucidate if anti-inflammatory effects α-ch observed previous studies can alleviate lung, kidney injuries...
Background: Peptic ulcer disease, a painful lesion of the gastric mucosa, is considered one most common gastrointestinal disorders. This study aims to investigate formulation pumpkin seed oil (PSO)-based nanostructured lipid carriers (NLCs) utilize PSO as liquid component NLCs and achieve dispersion in nano-range stomach. Methods: Box–Behnken design was utilized deduce optimum formula with minimum particle size. The optimized PSO-NLCs investigated for protective effects Wistar rats by...
Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching submucosa. This study aimed formulate and optimize omega-3 oil as self-nanoemulsifying drug delivery system (SNEDDS) achieve dispersion in nano-range stomach augment gastric protection efficacy. Three SNEDDS components were selected design factors: concentrations (X1, 10-30%), surfactant tween 20 Kolliphor mixture (X2, 20-40%), cosurfactant transcutol (X3, 40-60%). The experimental proposed...
Sepsis is an extensive life-threatening illness that occurs due to abnormal host response extends through the initial storm of inflammation and oxidative stress terminates at late stage immunosuppression. Among global intensive care units, sepsis-induced acute kidney injury reported with high mortality rate. The purpose this study was evaluate protective effect renin angiotensin aldosterone system (RAAS) inhibition on sepsis outcomes. Cecal ligation puncture (CLP) procedure applied for...
Broccoli (Brassica oleracea) is reported to possess antioxidant activity that could potentially prevent oxidative damage tissues caused by many diseases. In the present study, we investigated preventive effect of broccoli leaf by-product extract (BL) on gentamicin-induced renal and hepatic injury measuring tissue activities morphological apoptotic changes. was thoroughly extracted with 70% methanol yield total (TME). The phenolic content (TPC) determined. Thirty male rats were divided into...
The subfornical organ (SFO) is an important sensory circumventricular implicated in the regulation of fluid homeostasis and energy balance. We investigated whether SFO activated by hormone cholecystokinin (CCK). CCK₁ CCK₂ receptors were identified RT-PCR. Dissociated neurons that responded to CCK (40/77), mostly depolarized (9.2 ± 0.9 mV, 30/77), but some hyperpolarized (-7.3 1.1 10/77). next examined responses vivo (16 μg/kg ip), presence absence or receptor antagonists (devazepide; 600...
Depression is a common mental disturbance that can be categorized as mild, moderate or severe. Mesemberine alkaloids, the main recognized phytoconstituents of some plants belonging to family Mesembryanthemaceae, are well-known serotonin reuptake inhibitors. Therefore, objective this study evaluate antidepressant activity alkaloidal fraction Mesembryanthemum cordifolium L.f. (Aptenia cordifolia) roots, Mesembryanthemaceae using forced swimming test, assisted by metabolomic analysis and in...
Abstract Stroke is a medical emergency that associated with substantial mortality and functional disability in adults. The most popular class of antidepressants, selective serotonin reuptake inhibitors SSRIs, have recently been shown studies to positive effects on post-stroke motor cognitive function. Thus, we hypothesized dapoxetine (DAP), short-acting SSRI, would be effective against cerebral ischemia/reperfusion injury. Adult male Wister rats (200–250 g) were subjected sham operation or...
In cases of sepsis, the immune system responds with an uncontrolled release proinflammatory cytokines and reactive oxygen species. The lungs, kidneys, liver are among early impacted organs during sepsis a direct cause mortality. aim this study was to compare effects infliximab (IFX) celecoxib (CLX) on septic rats that went through cecal ligation puncture (CLP) surgery induce sepsis. This included four groups: sham, CLP (untreated), CLP-treated CLX or IFX. administration “low dose” IFX...
Sepsis-induced acute lung injury (ALI) and kidney (AKI) are major causes of mortality. Menthol is a natural compound that has anti-inflammatory antioxidative actions. Since exaggerated inflammatory oxidative stress characteristics sepsis, the aim this study was to evaluate effect menthol against sepsis-induced mortality, ALI, AKI.The cecal ligation puncture (CLP) procedure employed as model sepsis. Rats were grouped into sham, sham-Menthol, CLP, CLP-Menthol (100 mg/kg, p.o).A survival showed...