A5074808438- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Edible Oils Quality and Analysis
- Natural Antidiabetic Agents Studies
- Genomics, phytochemicals, and oxidative stress
- Sesame and Sesamin Research
- Cell death mechanisms and regulation
- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Pomegranate: compositions and health benefits
- Medical Imaging and Analysis
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Drug-Induced Hepatotoxicity and Protection
- Growth Hormone and Insulin-like Growth Factors
- Nigella sativa pharmacological applications
- Pharmacological Effects of Medicinal Plants
- Berry genetics and cultivation research
- Thermoregulation and physiological responses
- Thermoelastic and Magnetoelastic Phenomena
Prince Sattam Bin Abdulaziz University
2023-2024
King Abdulaziz University
2019-2024
University of Benghazi
2022
King Abdul Aziz University Hospital
2020
United Nations
2018
University of Florida
2014-2016
An early diagnosis of lung and colon cancer (LCC) is critical for improved patient outcomes effective treatment. Histopathological image (HSI) analysis has emerged as a robust tool diagnosis. HSI LCC includes the examination tissue samples attained from to recognize lesions or cancerous cells. It significant role in staging this tumor, which aids prognosis treatment planning, but manual subject human error also time-consuming. Therefore, computer-aided approach needed detection using HSI....
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system characterized by demyelination nerves, neural degeneration, axonal loss. Cognitive impairment, including memory decline, significant feature in MS affecting up to 70% patients. Thereby, it substantially impacts patients' quality life. Biochanin A (BCA) an o-methylated isoflavone with wide variety pharmacological activities, antioxidant, anti-inflammatory, neuroprotective activities....
Hyperthermia therapy is now being used to treat cancer. However, understanding the pattern of temperature increase in biological tissues during hyperthermia treatment essential. In recent years, many physicians and engineers have studied use computational mathematical models heat transfer systems. The rapid progress computing technology has intrigued researchers. Many medical procedures also engineering techniques modeling ensure their safety assess risks involved. One such model modified...
Lipopolysaccharide (LPS) administration is one of the most commonly used methods for inducing inflammation in animal models. Several studies have investigated effects acute and chronic peripheral LPS on cognitive impairment. However, no previous study has compared different doses chronically administered recognition memory performance.Here, we aimed to investigate optimal dose induction impairment mice.LPS at (0.25, 0.50 0.75 mg/kg) was SWR/J mice daily 7 days. On day 9, open field, novel...
Stimulation of remyelination is critical for the treatment multiple sclerosis (MS) to alleviate symptoms and protect myelin sheath from further damage. The current study aimed investigate possible therapeutic effects combining vitamin D3 (Vit D3) siponimod (Sipo) on enhancing modulating microglia phenotypes in cuprizone (CPZ) demyelination mouse model. was divided into two stages; (first 5 weeks) (last 4 weeks). In first weeks, 85 mice were randomly groups, control (n = 20, standard rodent...
The aqueous extracts of MAE were phytochemically analyzed, and the results revealed presence high concentrations tannins, sterols, isoprenoids (terpenoids), while steroids flavonoids found in moderate concentrations. plant extract showed promising inhibition growth gram-positive gram-negative pathogens. It also that has potential antihyperglycemic antioxidant activities. Microscopic examination pancreas degenerative changes atrophy associated with dilatation exocrine ducts STZ-induced...
Prostate cancer (PCa) is becoming one of the most frequently occurring cancers among men and causes an even greater number deaths. Due to complexity tumor masses, radiologists find it difficult identify PCa accurately. Over years, several PCa-detecting methods have been formulated, but these cannot efficiently. Artificial Intelligence (AI) has both information technologies that simulate natural or biological phenomena human intelligence in addressing issues. AI broadly implemented healthcare...
L-arginine (L-Arg) is one of the most widely used amino acids in dietary and pharmacological products. However, evidence on its usefulness dose limitations, especially diabetics still controversial. To investigate effects chronic administration different doses L-Arg cardiac muscle type 2 diabetic rats. Of 96 male rats were divided into 8 groups as follows (n = 12): Control, 0.5 g/kg L-Arg, 1 1.5 diabetic, + L-Arg; whereas was orally administered for 3 months to all treated groups. produced a...
Recently, artificial intelligence (AI) with deep learning (DL) and machine (ML) has been extensively used to automate labor-intensive time-consuming work help in prognosis diagnosis. AI's role biomedical biological imaging is an emerging field of research reveals future trends. Cervical cell (CCL) classification crucial screening cervical cancer (CC) at earlier stage. Unlike the traditional method, which depends on hand-engineered or crafted features, convolution neural network (CNN) usually...
Lung cancer is a dangerous type of in men and the third leading cause cancer-related death women, behind breast colorectal cancers. Thymoquinone (THQ), main compound black seed essential oils, has variety beneficial effects, including antiproliferative, anti-inflammatory, antioxidant properties. On other hand, scorpion venom peptides (SV) induce apoptosis cells, making it promising anticancer agent. THQ, SV, Phospholipon® 90H (PL) were incorporated nano-based delivery platform to assess...
Alzheimer's disease (AD) presents a significant global health concern, characterized by neurodegeneration and cognitive decline. Neuroinflammation is crucial factor in AD development progression, yet effective pharmacotherapy remains elusive. Sulforaphane (SFN), derived from cruciferous vegetables mainly broccoli, has shown promising effect via vitro vivo studies as potential treatment for AD. This study aims to investigate the possible prophylactic mechanisms of SFN against prefrontal...
Icariin (ICA), a main active compound of the Epimedium genus, is used as an aphrodisiac in traditional Chinese herbal medicine. Despite its therapeutic efficacy, ICA displays reduced oral absorption, and therefore, low bioavailability hindered clinical application. Implementing nanotechnology field formulation has been focus to improve efficacy ICA. In this regard, polymeric nanoparticles find potential application drug delivery systems. A nanosphere formula was designed, aiming drug’s...
In the Middle East and North Africa (MENA) region, dogs are main reservoir for rabies. this rabies affects more domestic carnivores (50% of cases) than farm animals (40% cases). Rabies in large livestock animals, which infected mainly by dogs, results economic losses, undermines food safety poses a risk humans. MENA is largely an urban problem, virus being transmitted to humans free-roaming 30% less one year old. cities, density dog population varies between 0.6 1.5 per km2, almost double...
Abstract Background Cranberry has been studied as a potential anticancer agent it is capable of inducing apoptosis within cancer cells. The aim this study was to better define the mechanism by which cranberry triggers in HL-60 Methods carried on extracts (CB). Anti-apoptotic B-cell lymphoma-2 (BCL-2) and pro-apoptotic BCL-2-associated death promoter (BAD) proteins cell lysates were detected through Western blotting techniques. Equivalent protein loading confirmed anti-α-tubulin antibody....
Background: Chemically induced cirrhotic animal models are commonly used. However, they have limitations such as high mortalities and low yield of animals that limit their uses. Aims: To overcome the chemically model via combined administration methotrexate (MTX) with CCl4 decrease used doses depending on proposed synergetic effect. Methods: Rats were divided into six groups: normal (4 weeks), (8 MTX, MTX + weeks) groups. Animals' hepatic morphology histopathological characterization...