A5046179614- Ginger and Zingiberaceae research
- Biodiesel Production and Applications
- Thermochemical Biomass Conversion Processes
- Pomegranate: compositions and health benefits
- Computational Drug Discovery Methods
- Antioxidant Activity and Oxidative Stress
- Protein Hydrolysis and Bioactive Peptides
- Liver Disease Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Natural Compounds in Disease Treatment
- Meat and Animal Product Quality
- Monoclonal and Polyclonal Antibodies Research
- Subcritical and Supercritical Water Processes
- Algal biology and biofuel production
- Vaccine Coverage and Hesitancy
- Moringa oleifera research and applications
- Cynara cardunculus studies
- Alzheimer's disease research and treatments
- Sugarcane Cultivation and Processing
- Traditional and Medicinal Uses of Annonaceae
- Tryptophan and brain disorders
- Drug-Induced Hepatotoxicity and Protection
- Zeolite Catalysis and Synthesis
- Phytochemical compounds biological activities
- Cytokine Signaling Pathways and Interactions
University of Jeddah
2016-2025
University of Surrey
2015-2016
Plant polyphenols are reported to have bioactive properties, which may be used for protection against diseases. Therefore, the aim of this research was investigate antioxidant activities a pomegranate tannin polyphenol compound, punicalagin and juice. The presence in husk (US) juice (US & UK) compared with standard using high performance liquid chromatography (HPLC) chromatography-mass spectroscopy (LC-MS) highly sensitive selective analytical methods separation identification phenolic...
Background: Breast cancer remains a significant global health concern, with approximately 2.3 million diagnosed cases and 670,000 deaths annually. Current targeted therapies face challenges such as resistance adverse side effects. This study aimed to explore natural compounds potential multitargeted breast therapeutics, focusing on Lucidin, an anthraquinone derived from Rubia cordifolia, comparing its efficacy Lapatinib, FDA-approved drug. Methods: We performed molecular docking studies key...
This work focused on exploring the bioenergy potential of biomass produced salt-affected soils by growing two types grasses, namely Parthenium hysterophorus (carrot grass) and Pennesetum benthiumo (mott grass), without using fertilizers or pesticides. The whole plant both grasses was pyrolyzed at three heating rates (10, 30, 50 °C min−1) in a joined Thermogravimetry–Differential Scanning Calorimetry (TGA–DSC) analyzer under an inert (nitrogen) environment. pyrolysis shown to occur...
Background: Signal transducer and activator of transcription 3 (STAT3) is a factor that controls cell proliferation, differentiation, angiogenesis, immunological responses. In many human malignancies, abnormal STAT3 activation promotes tumor growth via oncogenic gene expression, resulting in malignancy. Many drugs with clinically authorized analogues are used as inhibitors for cancer therapy have several drawbacks terms stability toxicity.Methods: This study PyRx 0.8 tool to screen the...
Egg yolk peptides were successfully prepared from egg protein by-products after lecithin extraction. Defatted was hydrolyzed with pepsin and pancreatin purified by gel filtration to produce fraction (EYGF-33) antiproliferative activity. The highlight of this study that the peptide EYGF-33 (1.0 mg/ml) significantly inhibits cell viability colon cancer cells (Caco-2) no inhibitory effects on human epithelial normal (HCEC) 48 h. Reduced can be explained cycle arrest in S-phase which DNA...
COVID-19 has killed over 6 million people worldwide, making it the worst global health disaster since 1918 influenza pandemic. Experts have worked to establish source, track and analyse disease, produce treatment preventative guidelines. Inactivated vaccines little evidence of efficacy compared mRNA adenoviral vector vaccines; however, three doses both inactivated appear provide significant lasting protection against severe disease mortality. This study examines vaccine effectiveness data by...
Hydrolysable tannin polyphenols from pomegranate (punicalagin) have been reported to show a wide range of health properties correlated their high antioxidant and free radical scavenging activities. The objective the current study was investigate protective effect punicalagin on cell viability redox status cultured Caco-2 cells exposed oxidative stress induced by tert-butyl hydroperoxide. production malondialdehyde, total glutathione levels, as well generation reactive oxygen species were...
Background: Chemically induced cirrhotic animal models are commonly used. However, they have limitations such as high mortalities and low yield of animals that limit their uses. Aims: To overcome the chemically model via combined administration methotrexate (MTX) with CCl4 decrease used doses depending on proposed synergetic effect. Methods: Rats were divided into six groups: normal (4 weeks), (8 MTX, MTX + weeks) groups. Animals' hepatic morphology histopathological characterization...
Oxidative stress can damage lipids, proteins and DNA.The effect of hydrolysed, purified defatted egg yolk protein by-product (fraction EYGF-23) on oxidative in Caco-2 colon cancer epithelial cells was investigated for the first time.Caco-2 exposed to toxic 3 mM tert-butyl hydroperoxide (t-BHP) 2 hours were protected when pretreated with 1.0 mg/ml EYGF-23 24 hours.The peptides inhibited intracellular reactive oxygen species (ROS) (60.0%) malondialdehyde (MDA) (24.2 µg/ml) production, compared...
Introduction: punicalagin, a hydrolysable tannin polyphenol from pomegranate, reported to have protective effect against many diseases due its high antioxidant and free radical scavenging activities. Aim, this study investigated the potential antihypertensive activity of punicalagin in human derived EA.hy926 endothelial cell model, via two mechanisms. In first mechanism, enhance nitric oxide production through reactive oxygen specious (ROS) activating synthase enzyme (eNOS). second showed by...
This review provides an extensive summary of the most current expansions on therapeutic potential ginger bioactive compounds in context cancer management. We delve into individual components and their distinct anti-cancer properties, highlighting diverse mechanisms action, including modulation signalling pathways cellular processes. Additionally, we explore synergistic effects that exhibit when combined with conventional treatments. Despite promising potential, also addresses challenges...
Background: Matrix metalloproteinase-2 (MMP2) plays a role in breaking down the components of extracellular matrix, which allows cancer cells to advance and invade. Therefore, inhibition MMP2 shows potential as promising strategy for treating cancer.Methods: This study employed computational screening identify inhibitors from collection 2,405 natural compounds. GLXC-26716, co-crystal ligand MMP2, served positive control. Virtual was performed using PyRx 8.0 software find molecules that might...
Background: NIMA-related kinase 7 (NEK7) is a serine/threonine that required for cell cycle progression, particularly mitotic spindle formation and cytokinesis, has been linked to various cancers. Furthermore, NEK7 modulates the NLRP3 inflammasome, which activates Caspase-1 causes pyroptosis. A growing body of studies indicates ginger ability prevent treat variety health issues.Methods: In this study, 383 distinct bioactive compounds were extracted from LOTUS database Zingiber officinale...