A5074675838- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
- Lipoproteins and Cardiovascular Health
- Natural product bioactivities and synthesis
- Antifungal resistance and susceptibility
- Healthcare and Venom Research
- Lipid Membrane Structure and Behavior
- Phytochemical compounds biological activities
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Toxin Mechanisms and Immunotoxins
- Pomegranate: compositions and health benefits
- Graphene and Nanomaterials Applications
- Bee Products Chemical Analysis
- Nanoplatforms for cancer theranostics
- Estrogen and related hormone effects
- Phytochemicals and Antioxidant Activities
- Advanced biosensing and bioanalysis techniques
- Medicinal Plant Pharmacodynamics Research
King Abdulaziz University
2016-2025
University of Benin
2020
King Abdul Aziz University Hospital
2014
University of Strathclyde
2011
Abstract Exosomes are nano-sized endosome-derived small intraluminal vesicles, which important facilitators of intercellular communication by transporting contents, such as protein, mRNA and microRNAs, between neighboring cells, in the tumor microenvironment. The purpose this study was to understand mechanisms exosomes-mediated cellular human pancreatic cancer (Panc-1) cells macrophages (J771.A1) using a Transwell co-culture system. Following characterization exosome-mediated pro-tumoral...
The objective of the present study was to develop, optimize, and evaluate rotigotine-loaded chitosan nanoparticles (RNPs) for nose-to-brain delivery. Rotigotine-loaded were prepared by ionic gelation method optimized various parameters such as effect chitosan, sodium tripolyphosphate, rotigotine concentration on particle size, polydispersity index (PDI), zeta potential, entrapment efficiency. characterized using photon correlation spectroscopy, transmission electron microscopy, scanning...
Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for potential in drug delivery of agents. Thus, the purpose this study was determine enhancement ICA cytotoxicity activity OVCAR-3 via its formulation phytosomes. ICA-phytosomal optimized using Box–Behnken design. Particle size, shape, vitro release were used characterize...
Naringenin (NAR), a flavonoid mainly found in citrus and grapefruits, has proven anti-cancer activities. However, the poor water solubility low bioavailability of NAR limits its use as therapeutic agent. The aim this study was to develop optimize stable naringenin nanoemulsions (NAR-NE) using Box-Behnken experimental design obtain formulation with higher efficiency. Anticancer activity optimized NAR-NE evaluated A549 lung cancer cells cell viability, flow-cytometric assays, enzyme-linked...
Abstract Bacterial biofilms contribute to increased pathogenesis and bacterial resistance. Biofilms can enhance pathogenicity by shielding bacteria from the immune system antibiotics, they are associated with persistent infections. Additionally, antibiotic resistance mechanisms within make them challenging treat, emphasizing need for strategies be addressed. Mitigating virulence is a promising strategy that could ease their eradication host immunity without stressing induce The merits of...
Parkinson’s disease (PD) is a neurodegenerative disorder resulting in decreased nigrostriatal availability of dopamine. Oxidative stress one factor contributing to PD. Naringenin (NAR), flavonoid, potent antioxidant shown be beneficial experimental The clinical development NAR has been hampered due its low bioavailability from gastrointestinal degradation, inefficient permeability, and aqueous solubility. objective the present research was formulate characterize naringenin-loaded chitosan...
Abstract: Lemongrass oil (LGO) is a volatile extracted from the leaves of Cymbopogon citratus that has become one most important natural oils in pharmaceutical industry because its diverse pharmacologic and clinical effects. However, LGO suffers low aqueous solubility, which could lead to reduced effect. Moreover, instability major active constituent, citral, volatilization, reaction with other formulation ingredients, consequently, skin irritation. To surmount these problems, this research...
Resveratrol (RES) is a polyphenolic compound which has shown beneficial pharmacological effects such as anti-inflammatory, antioxidant, and anti-cancer effects. However, poor aqueous solubility, bioavailability, low stability are the major limitations to clinical application of RES. Therefore, in present study, chitosan (CS) coated PLGA nanoparticles RES (CS-RES-PLGA NPs) was developed, characterized its anticancer activity evaluated H1299 lung carcinoma cell line. The increase CS coating...
Luliconazole is a potential prescription candidate drug for the treatment of topical fungal infections. However, it has water solubility and skin permeability limitations. To overcome these limitations, niosomal gel luliconazole was formulated using Span 60, cholesterol, chloroform to improve its bioavailability reduce toxicity. Niosomes were analyzed by transmission electron microscopy (TEM) Fourier transform infrared spectroscopy (FTIR) morphological spectral studies respectively. The...
Plumbagin (PLM) is a phytochemical which has shown cytotoxicity against of cancer cells both in vitro and vivo. However, the clinical application PLM been hindered due to poor aqueous solubility low bioavailability. The aim present study was develop, optimize evaluate PLM-loaded glycerosome (GM) gel compare with conventional liposome (CL) for therapeutic efficacy skin cancer. GM formulations were optimized by employing design expert software 3-level 3-factor design. prepared GMs...
The second most common cause of mortality among women is breast cancer. A variety natural compounds have been demonstrated to be beneficial in the management various malignancies. Resveratrol a promising anticancer polyphenolic compound found grapes, berries, etc. Nevertheless, its low solubility, and hence bioavailability, restrict therapeutic potential. Therefore, our study, we developed thermosensitive hydrogel formulation loaded with resveratrol nanoemulsion enhance bioavailability....
The methanol extract of the fruit pulp Adansonia digitata L. (Malvaceae) was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. principle depends on fact that administration will be associated with development oxidative stress. In addition, hepatospecific serum markers disturbed. Treatment rats prior to significantly reduced disturbance function. Liver functions were measured assessment total protein, bilirubin, ALP, ALT, and AST. Oxidative...
Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB centrally acting drug has low bioavailability 33% owing to its exposure hepatic first-pass effect, as well pH-dependent solubility, which could be an obstacle hindering dissolution and absorption via mucosal barriers. Thus, this work aimed at overcoming aforementioned drawbacks promoting nose-to-brain delivery...
Piceatannol (PIC), a naturally occurring polyphenolic stilbene, has pleiotropic pharmacological activities. It reported cytotoxic activities against different cancer cells. In the present study, PIC emulsomes (PIC-E) were formulated and assessed for activity. A Box-Behnken design was employed to investigate influence of formulation factors on particle size drug entrapment. After optimization, had spherical shape with 125.45 ± 1.62 nm entrapment efficiency 93.14% 2.15%. Assessment indicated...
Cisplatin is one of the most leading potent chemotherapy drugs prescribed for treatment solid tumors. However, induction toxicities and development resistance restricts its applications. Efforts are made in proposed study to control delivery cisplatin tumor sites by incorporating it into lipid nanoparticle (SLNs) drug carriers. By considering this fact, current research work, a single-step, one-pot, microwave-assisted technology was used produce cisplatin-loaded SLNs. The shape SLNs observed...
This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release double coated microparticles dependent on time pH. At pH 7.4 maximum observed for 6 h. efficiency coat to target colonic tissues confirmed using real-time X-ray radiography iohexol dye. Entrapment particle size were used characterization formula. Cytotoxicity HCT-116 cells significantly...