A5071276384- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- RNA and protein synthesis mechanisms
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Cancer-related gene regulation
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Axon Guidance and Neuronal Signaling
- Escherichia coli research studies
- Plant chemical constituents analysis
- Phytochemistry and Biological Activities
- Microbial Metabolism and Applications
- Genomics and Phylogenetic Studies
- Pharmacological Effects of Natural Compounds
- Synthesis and biological activity
- Ginseng Biological Effects and Applications
- Ziziphus Jujuba Studies and Applications
- Ginger and Zingiberaceae research
- Click Chemistry and Applications
- HER2/EGFR in Cancer Research
- Wnt/β-catenin signaling in development and cancer
- Signaling Pathways in Disease
Damanhour University
2016-2024
University of Iowa
2022-2024
Royal University Hospital
2016-2023
University of Saskatchewan
2016-2023
A series of novel thiazole-based chalcones were evaluated for their anticancer activity as potential tubulin polymerization inhibitors. In vitro screening the thiazole derivatives
Triple-negative breast cancer (TNBC) tumours that lack expression of oestrogen, and progesterone receptors, do not overexpress the HER2 receptor represent most aggressive subtype, which is characterised by resistance to therapy in frequently relapsing a high rate patient mortality. This likely due slowly proliferating tumour-initiating cells (TICs), understanding molecular mechanisms control TICs behaviour crucial for development effective therapeutic approaches. Here, we present our novel...
Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid development targeted cancer therapies. Although many these treatments produce impressive initial responses, eventual resistance onset is practically unavoidable. One the main approaches for preventing this refractory condition relies on implementation combination This includes dual-specificity reagents that affect both their targets with high level selectivity. Unfortunately, selection target combinations often...
// James M. Paul 1, * , Behzad Toosi 2, Frederick S. Vizeacoumar Kalpana Kalyanasundaram Bhanumathy 2 Yue Li 3, 4, 5 Courtney Gerger Amr El Zawily 6 Tanya Freywald 7 Deborah H. Anderson Darrell Mousseau 8 Rani Kanthan Zhaolei Zhang 4 Franco J. Andrew 1 Department of Biochemistry, University Saskatchewan, Saskatoon, SK, S7N 5E5, Canada Pathology and Laboratory Medicine, College Royal Hospital, 0W8, 3 Computer Science, Toronto, ON, M5S 3G4, The Donnelly Centre, 3E1, Present address: Science...
Cancer continues to be one of the biggest causes death that affects human health. Chemical resistance is still a problem in conventional cancer treatments. Fortunately, numerous natural compounds originating from different microbes, including fungi, possess cytotoxic characteristics are now well known. This study aims investigate anticancer prospects five fungal strains were cultivated and isolated Red Sea soft coral Paralemnalia thyrsoides. The vitro potential ethyl acetate extracts...
While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail approximately 25% of patients and these limited options. Another significant group is being overtreated, which causes long-lasting side effects. Identification molecules controlling drug resistance crucial for optimisation both scenarios. We report here the EphB6 receptor frequently overexpressed T-ALL. Remarkably, our observations indicate that acts cells to enhance sensitivity a...
Ginger rich in polyphenols, possesses various biomedical properties. Researchers investigated the effects of dietary ginger supplementation on turkey performance traits, biochemical parameters, haematological parameters and mRNA gene expression. root powder was administered at different doses (0, 10, 20 40 g/kg) to turkeys. Notably, g/kg group exhibited improved traits a higher broiler production efficiency factor (BPEF). Importantly, found be safe for turkeys based serum indices....
Chorisia (syn. Ceiba) species are important ornamental, economic, and medicinal plants that endowed with a diversity of secondary metabolites; however, their volatile organic compounds (VOCs) have been scarcely studied. Therefore, this work explores compares the headspace floral volatiles three common species, namely chodatii Hassl., speciosa A. St.-Hil, insignis H.B.K. for first time. A total 112 VOCs varied biosynthetic origins were identified at different qualitative quantitative ratios,...
Abstract Cancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source anticancer medications. A phytochemical investigation edible Ziziphus spina-christi (F. Rhamnaceae) leaf extract afforded two new dammarane type saponins identified as christinin E and F ( 1, 2 ), along with known compound 3 ). Different cancer cell lines, such lung (A549), glioblastoma (U87), breast (MDA-MB-231), colorectal carcinoma...
Sixteen chemically varied metabolites were isolated from the bulbs of Hippeastrum vittatum (L'Her.) Herb., including eight flavonoids [3′-methyl isoliquiritigenin (2), 7-hydroxyflavan (8), 7-hydroxyflavanone (9), 7-hydroxyflavan-3-ol (10), 7-methoxy-3′,4′-methylenedioxyflavan-3-ol (11), 7-hydroxy-3′,4′-methylenedioxy flavan (12), 2′,4′-dihydroxy-3′-methyl-3,4-methylenedioxychalcone (13), and (14)], four acetophenones [2,6-dimethoxy-4-hydroxyacetophenone (3), 2,4-dihydroxyacetophenone (4),...
Malaria is a persistent illness with great public health concern. To combat this fatal disease, developing effective antimalarial medications has become necessity. In the present study, we described actinomycetes associated Red Sea soft coral Nephthea sp. and isolated strain that was sub-cultured in three different media (M1, ISP2, OLIGO). Actinomycete isolate's phylogenetic analysis of 16S rRNA gene revealed it belongs to genus Rhodococcus. vitro screening activity for extracts against...
AbstractEndophytic fungi are known to be a rich source for anti-infective drugs. In this study, Aptenia cordifolia associated endophytic were explored the first time. Seven isolates identified morphologically followed by screening of these plug diffusion assay which revealed their potential activity against Staphylococcus aureus (ATCC 9144), Bacillus cereus 14579), Serratia marcescens 14756), Fusarium oxysporum 48112), and Aspergillus flavus 22546). Additionally, crude ethyl acetate extract...
The emergence of multidrug-resistant (MDR) E. coli has developed worldwide; therefore, the use antibiotic combinations may be an effective strategy to target resistant bacteria and fight life-threatening infections. current study was performed evaluate in vitro vivo efficacy amikacin imipenem alone combination against coli. Methods: treatment assessed using a checkerboard technique time-killing curve peritonitis mouse model. In isolates, conventional PCR quantitative real-time techniques...
<p>Fig. S4. A. Heatmap of the shRNA screen hits that are enriched in top 15 GO processesgenerated using GSEA software. B. Gene Set Enrichment Analysis plots GOprocess for data produced by software used to generate heatmap inA.</p>
<p>Fig. S6. EPHA2, c-MET and EGFR levels in human tumors.</p>
<p>Fig. S4. A. Heatmap of the shRNA screen hits that are enriched in top 15 GO processesgenerated using GSEA software. B. Gene Set Enrichment Analysis plots GOprocess for data produced by software used to generate heatmap inA.</p>
<p>Fig. S2. A. Heatmap of the differentially expressed phosphorylated proteins that are enriched inthe top 15 gene ontology (GO) processes generated using GSEA software. B. Gene SetEnrichment Analysis plots GO for expressedphosphorylated data produced by software used to generate heatmap in A.</p>
<p>Fig. S3. A. Correlation cluster for both the replicates and different timepoints of screeningdata. B. Fold-change distribution from normalized shRNA intensity αEPHA2-Condand cIgG-Tr cells at time points. C. Precision-recall curves after applying BAGELalgorithm to screening data. F measure provided in inset represents harmonic mean ofprecision & recall screen.</p>
<p>Fig. S5. A. Heatmap of the BioID hits that are enriched in top 15 GO processes based onGSEA software. B. Gene Set Enrichment Analysis plots process for BioIDdata produced by GSEA software used to generate heatmap A.</p>
<p>-Supplementary Materials</p>