Metabolomics is a fast growing technology that has effectively contributed to many plant-related sciences and drug discovery.To use the non-targeted metabolomics approach investigate chemical profiles of three Malvaceae plants, namely Hibiscus mutabilis L. (Changing rose), H. schizopetalus (Dyer) Hook.f. (Coral Hibiscus), Malvaviscus arboreus Cav. (Sleeping along with evaluating their antioxidant anti-infective potential.Metabolic profiling was carried out using liquid chromatography coupled...

Malvaviscus arboreus Cav. is a medicinal plant belonging to family Malvaceae with both ethnomedical and culinary value; however, its phytochemical biological profiles have been scarcely studied. Accordingly, this work was designed explore the chemical composition hepatoprotective potential of M. against carbon tetrachloride (CCl4)-induced hepatotoxicity. The total extract aerial parts derived fractions (petroleum ether, dichloromethane, ethyl acetate, aqueous) were orally administered rats...

Soft corals have been endorsed as a plentiful source of bioactive compounds with promising anti-inflammatory activities; therefore, exploring their potential metabolites has stimulated growing research interest.To investigate the soft coral, Nephthea sp., in its bulk and silver nanostructure. Metabolomics analysis followed by molecular docking studies, was also conducted order to explore predict secondary that might provide inhibitory actions on inflammation.The petroleum ether ethyl acetate...

Peptic ulcer is a major health disease which could be defined as destruction in different parts of the gastrointestinal track mainly lining mucosa stomach well proximal duodenum. Additionally, treatment this illness emphases challenges currently available medications have side effects limited effectiveness. On other hand, natural products exhibited chief role prevention and curing various issues. Different metabolites such alkaloids (as isocorydine), flavonoids Sofalcone), terpenoids...

Abstract Background Solanum lycopersicum Linn. (Tomato, Family Solanaceae) is one of the fruits that are most consumed worldwide. The current research intends to emphasise possibility positive and therapeutic effects S. seed extract (SLSE) on Alzheimer's disease's neurodegeneration being reversed in a study utilising rats exposed aluminium chloride. Investigations were done cholinesterase antioxidant vitro activity SLSE. Rats with disease given SLSE, donepezil (500, 10 mg/kg.b.wt., daily for...

Abelmoschus esculentus Linn. (okra, F. Malvaceae) is a fruit widely consumed all over the world. In our study, anti-Alzheimer's potential of A. was evaluated. An in vitro DPPH free radical assay on seed's total extract and AChE inhibition screening indicated significant activity extract, which confirmed through an vivo study aluminum-intoxicated rat model. Additionally, results demonstrated improvement Alzheimer's rats, by improving T-maze, beam balance tests, lower serum levels AChE,...

The ongoing spread of SARS-CoV-2 has created a growing need to develop effective antiviral treatments; therefore, this work was undertaken delve into the natural metabolites Red Sea soft coral Nephthea sp. (family Nephtheidae) as source potential anti-COVID-19 agents. Overall, total 14 structurally diverse minor constituents were isolated and identified from petroleum ether fraction characterised compounds screened compared for their inhibitory against main protease (Mpro) using Autodock...

Nature has proven to be a treasure resource of bioactive metabolites. In this regard, Tamarix aphylla (F. Tamaricaceae) leaves crude extract was investigated for its gastroprotective effect against indomethacin-induced damage the gastric mucosa. Additionally, phytochemical investigation methanolic afforded eight flavonoids’ derivatives ( 1–8 ). On pharmacology networking study, isolated compounds identified 123 unique targets where only 45 were related peptic ulcer conditions, these include...

Sponge-associated microorganisms are promising resources for the production of bioactive compounds with cytotoxic potential. The main goal our study is to isolate fungal endophytes from Red Sea sponge Hyrtios sp. followed by investigating their cytotoxicity against number cell lines.

The cytotoxic potential of the crude extract, different fractions, and green synthesized nanoparticles soft coral<italic>Nephthea</italic>sp. was studied, supported by LC-HR-ESI-MS metabolomics analysis molecular docking dereplicated compounds.

Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, Allium cepa was investigated for fungal diversity using different media give 11 isolates which were identified morphologically. Out the isolated strains, Penicillium sp. (LCEF10) revealed potential activity against tested microbes (Fusarium solani ATTC 25922, Pseudomonas aeruginosa (ATTC 29231), Staphylococcus aureus 27853, Candida albicans 10231), besides, their MICs measured by well diffusion method,...

Cancer is a major disease that threatens human health all over the world. Intervention and prevention in premalignant processes are successful ways to prevent cancer from striking. On other hand, marine ecosystem treasure storehouse of promising bioactive metabolites. The use such products can be optimized by selecting suitable nanocarrier. Therefore, epi-obtusane, previously isolated Aplysia oculifera, was investigated for its potential anticancer effects toward cervical through series...

Abstract. Malvaviscus arboreus Cav., commonly known as Sleeping Hibiscus, is a plant species that belongs to the family Malvaceae with ornamental, culinary, and ethnomedical importance. This medicinal herb was reported exhibit noteworthy antioxidant, cytotoxic, hepatoprotective, anti-infective activities attributed presence of variety phytochemicals. In this work, volatile compositions leaves flowers M. were studied compared for first time using headspace gas chromatography-mass spectrometry...

Soft corals and associated microorganisms are known to produce leads for anticancer drugs. Keeping this in mind, Nephthea sp.; a Red Sea soft coral was investigated the first time using OSMAC approach. Two isolates, Streptomyces sp. UR63 Micrococcus UR67 were identified. Their extracts revealed presence of alkaloids, macrolides, quinones, fatty acids terpenoids. Further comparison through set multivariate data analyses their unique chemical profiles. The displayed inhibitory potencies...

AbstractEndophytic fungi are known to be a rich source for anti-infective drugs. In this study, Aptenia cordifolia associated endophytic were explored the first time. Seven isolates identified morphologically followed by screening of these plug diffusion assay which revealed their potential activity against Staphylococcus aureus (ATCC 9144), Bacillus cereus 14579), Serratia marcescens 14756), Fusarium oxysporum 48112), and Aspergillus flavus 22546). Additionally, crude ethyl acetate extract...

Malvaviscus arboreus Cav. (Sleeping Hibiscus) is a species of flowering plants belonging to family Malvaceae with natural distribution throughout Central and South America. However, this perennial, medium-sized shrub has been also widely cultivated in several other tropical subtropical areas the globe. Sleeping Hibiscus characterized by an erect, cylindrical, glabrous stem monopodial branching, reaching up 0.5‒1 m height 0.2‒1 cm diameter. The carries simple, alternate, oval or ovate broadly...

Malvaceae plants have been reported to produce a wide range of structurally varied fatty acids.Therefore, in this work, the acid content Malvaviscus arboreus Cav.leaves was investigated using gas chromatography-mass spectrometry (GC-MS) technique.A total 17 acids were characterized, with noticeable abundance saturated (50.98%) that principally dominated by palmitic (32.15%).Moreover, number mono-, di-, and tri-unsaturated detected constituting 24.92% identified acids, which...

The current study aimed to evaluate the cytotoxic potential of total extract soft coral Nephthea sp. and its derived fractions (petroleum ether, ethyl acetate, n-butanol acetone) in addition their green synthesized silver nanoparticles (AgNPs) against hepatocellular carcinoma (HepG2) colon adenocarcinoma (HT29) cell lines.Of these, petroleum ether fraction exhibited potent inhibitory activity HepG2 cells, with an IC50 value 1.10 ± 0.03 μg/ml, while revealed significant HT29 cells (IC50= 3.69...

Historical gardens are considered an important part of the built cultural heritage peoples, as they contribute to creation urban and image city, help in improving physical, cultural, environmental, economic social values city.However, it is exposed disappearance its features or distortion a result neglect ill-considered interventions new activities that may lead deduction areas from change land uses meet needs.Therefore, researcher saw necessity emphasizing value historical gardens,...