A5007695504- Synthesis and biological activity
- Melanoma and MAPK Pathways
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Protein Kinase Regulation and GTPase Signaling
- Mosquito-borne diseases and control
- Cytokine Signaling Pathways and Interactions
- Synthesis of Organic Compounds
- Essential Oils and Antimicrobial Activity
- Natural Compounds in Disease Treatment
- HER2/EGFR in Cancer Research
- Click Chemistry and Applications
- Viral Infections and Vectors
- Fungal Biology and Applications
- Synthesis and Biological Evaluation
- Cancer-related Molecular Pathways
- Quinazolinone synthesis and applications
- Antimicrobial Peptides and Activities
- Medicinal Plant Research
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Nigella sativa pharmacological applications
Minia University
2019-2025
Deraya University
2019-2025
Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAFV600E inhibitors have been developed. The target compounds were synthesized tested in vitro against four cancer cell lines. Compounds 12, 15, 17 demonstrated strong antiproliferative activity GI50 values of 1.05 µM, 1.50 1.20 respectively. Hybrids showed inhibition BRAFV600E. inhibited EGFR-like erlotinib exhibited promising anticancer activity. Compound 12 is the most potent inhibitor proliferation induced apoptosis by increasing...
DNA gyrase and topoisomerase IV show great potential as targets for antibacterial medicines. In recent decades, various categories of small molecule inhibitors have been identified; however, none effective in the market. For first time, we developed a series disalicylic acid methylene/Schiff bases hybrids ( 5a-k ) to act agents targeting IV. The findings indicated that new 5f-k exhibited significant activity against Gram-positive Gram-negative bacteria, with efficacy ranging from 75% 115%...
Abstract Yellow fever (YF) is a mosquito‐borne virus with high mortality rates, affecting regions in South America and Africa. Despite the effectiveness of YF vaccines, increased global demand reports rare, severe side effects have spurred search for safer therapeutic alternatives. Current treatments lack specific antiviral drugs approved YF, underscoring need new, effective therapies. This study investigated potential Passiflora edulis f. leaf stem extracts as agents against yellow (YFV)....
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen associated with healthcare-related infections that are often challenging to treat. Conditions such as, skin and soft tissue infections, bloodstream pneumonia highlight the critical need for effective therapeutic strategies. Careful use of antibiotics under medical supervision essential prevent further emergence MRSA. Recent studies have documented antibacterial efficacy certain endophytic fungi extracts...
<title>Abstract</title> <italic>Corchorus olitorius</italic> L. Moench (Molokheia) is a common edible plant that rich in terpenoids and flavonoids. Later, for the first time, this article was planned to study potential of <italic>C. roots their nanocrystals against breast cancer (MCF-7), hepatocellular carcinoma (HepG2) colon (Caco-2) cell lines. Generally, total methanolic extract (TMECOR) inhibited growth MCF-7, HepG2 Caco-2 cells with IC<sub>50</sub> values 42.68 ± 1.96, 37.14 1.6 18.63...
Abstract As dual EGFR and BRAF V600E inhibitors, 2‐(3‐cyano‐4,6‐bis(aryl)‐2‐oxo‐1,2‐dihydropyridine‐1‐yl)‐ N ‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed. Compounds 8, 12 , 13 showed strong antiproliferative activity when the target compounds synthesized tested in vitro against four cancer cell lines. These hybrids have a inhibition on according to studies. The was inhibited by with IC 50 values between 89 110 nM, which equivalent those of erlotinib (IC = 80 nm). Compound...
A series of novel 3-cyanopyridone/pyrazoline hybrids (21-30) exhibiting dual inhibition against EGFR and BRAFV600E has been developed. The synthesized target compounds were tested in vitro four cancer cell lines. Compounds 28 30 demonstrated remarkable antiproliferative activity, boasting GI50 values 27 nM 25 nM, respectively. These exhibited inhibitory effects on both pathways. 30, akin to Erlotinib, displayed promising anticancer potential. Compound emerged as the most potent inhibitor...
The present study details the design, synthesis, and bio-evaluation of indoles
A series of new pyrazolylquinolin-2-ones were designed and synthesised. The structures the compounds validated by IR, NMR, elemental analysis. evaluated as antiproliferative agents targeting EGFR BRAF V600E .
The emergence of antibiotic-resistant Streptococcus pneumoniae necessitates the discovery novel therapeutic agents. This study investigated antimicrobial potential green-synthesized gold nanoparticles (AuNPs) fabricated using Arthrospira platensis extract. Characterization Fourier transform infrared spectroscopy revealed presence functional groups such as ketones, aldehydes, and carboxylic acids in capping agents, suggesting their role AuNP stabilization. Transmission electron microscopy...
A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one structures has been developed, with dual inhibitory actions on both EGFR BRAFV600E. These were tested in vitro against four different cancer cell lines. Compounds 8, 9, 18, 19 inhibited proliferation significantly the cells, GI50 values ranging from 1.20 to 1.80 µM when compared Doxorubicin (GI50 = 1.10 µM). Within this group hybrids, 18 exhibited substantial inhibition Molecular docking investigations...
Introduction Bacteria have acquired resistance to almost all antibiotics currently in use due their extensive, broad, and improper utilization over a prolonged period. DNA gyrase DHFR exhibit significant promise as targets for antibacterial therapeutics. Methods We developed series of disalicylic acid methylene/Schiff bases hybrids ( 6a-l ) that function agents by targeting DHFR. Results discussion The findings showed activity against both Gram-positive Gram-negative bacteria, with...
A series of new quinoline-based derivatives was designed and synthesised. The structures the compounds were validated by IR, NMR, elemental analysis. evaluated as antiproliferative agents targeting EGFR, HER2.
Abstract Methotrexate (MTX) is commonly employed in cancer treatment, but its clinical use restricted due to the MTX‐associated renal injury. This study investigates combined potential of Rhus coriaria (sumac) and bone marrow mesenchymal stem cells (BMMSCs) against MTX‐induced nephrotoxicity rats. The high‐resolution‐liquid chromatography‐mass spectrometry (HR‐LC‐MS) sumac extract tentatively identified 22 phytochemicals, mostly flavonoids, anthocyanins, steroids. Preparation liposomes...
Abstract Cancer is one of the leading causes mortality worldwide, making it a public health concern. A novel series pyrrolidine‐carboxamide derivatives 7a‐q were developed and examined in cell viability assay utilizing human mammary gland epithelial line (MCF‐10A), where all compounds exhibited no cytotoxic effects more than 85% at concentration 50 μM. Antiproliferative activity was evaluated vitro against four panels cancer lines A‐549, MCF‐7, Panc‐1, HT‐29. Compounds 7e , 7g 7k 7n 7o most...