A5101860148- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Synthesis of β-Lactam Compounds
- Eicosanoids and Hypertension Pharmacology
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis and Reactions of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Activity
- Synthesis of heterocyclic compounds
- Anesthesia and Sedative Agents
- Chemical Reactions and Isotopes
- Natural product bioactivities and synthesis
- Nonlinear Optical Materials Research
- Synthesis and Biological Evaluation
- Cancer Mechanisms and Therapy
- Radical Photochemical Reactions
- Synthesis and Reactivity of Heterocycles
- Melanoma and MAPK Pathways
- Pesticide Residue Analysis and Safety
Beni-Suef University
2007-2023
Cairo University
2007
Aim: The undeniable indomethacin potency has always suffered serious obstacles such as gastric damage. Continuous attempts to develop potent yet safe analogs have never ceased. Results: Herein are new indole derivatives 4a-h and 5a-c, which were synthesized via Fisher reaction, evaluated for both their in vivo anti-inflammatory activities using rat paw edema method vitro cyclooxygenase inhibitory activities. Then ulcerogenic liability, physicochemical parameters molecular docking modeling...
Experimentally designed HPLC method for simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities.
The British Pharmacopeia (BP) reported that the carcinogenic and hepatotoxic, benzophenone (BZP) is a dimenhydrinate (DMH) impurity. On other hand, cinnarizine (CIN) to have five impurities (A-E). toxicity profile of CIN was studied in silico data revealed impurity A [1-(diphenylmethyl)piperazine] (DPP) most toxic impurity, hence it selected during this work. TLC-densitometric method developed for separation simultaneous quantitation DMH, their impurities. In proposed hexane : ethanol...
p-Aminophenol (PAP) is a potentially toxic and mutagenic compound used and/or emitted in industrial, pharmaceutical agriculture fields. Ion-selective electrode potentiometry (ISE) introduces an effective tool for real-time, portable direct analysis to overcome lengthy sample preparation, treatment derivatization steps. The current work aims develop ISE-potentiometric sensor assay of PAP environmental biological matrices. Sensor assembly included glassy carbon upon which membrane cocktails...
Aim: Everyday studies prove the increasing need for newer and safer agents to control cellular inflammatory response, an underlying cause pathophysiology of many other clinical cases. Results: Two newly designed sets schiff 5a-h chlacone 6a-f substituted pyrazoles were synthesized evaluated their in vivo/vitro anti-inflammatory activities. Most potent representatives chosen investigation ulcerogenic molecular docking properties. Conclusion: The compounds showed considerable edema inhibition...
There has been an enormous commercial development following the introduction of selective COX-2 inhibitors. Efforts are continuously done to discover efficient and safe inhibitors.A series 4-methylsulfonylphenyl derivatives was designed, synthesized screened for preferential inhibition over COX-1 isoforms in vivo anti-inflammatory activity using rat paw edema method. The most active ones were investigated via ulcerogenic liability molecular docking. Physicochemical parameters calculated all...
Evaluation of antioxidant, antibacterial, antifungal and cytotoxic effects Clausena suffruticosa ethanolic root extractMd. Atiar Rahman, Joti Sankhar Chakma, Saiful Islam, Nazim Uddin Ahmed
Effect of Ketoprofen and Indomethacin on Methotrexate Pharmacokinetics in Mice Plasmaand Tumor TissuesYasmine M. Elmorsi, Sahar El-Haggar, Osama Ibrahim, Mokhtar Mabrouk
Abstract Combination therapy of gemcitabine and sorafenib is synergistically effective well tolerated in patients with non-small cell lung cancer (NSCLC). In this study, the pharmacokinetic parameters both were estimated after intra-peritoneal administration rats using novel, green sensitive RP-HPLC TLC-densitometric methods where sildenafil used as an internal standard. Firstly, developed method achieved on ZORBAX Eclipse Plus C 18 (4.6 mm × 150 mm, 5 μm) a mixture methanol: 40 mM ammonium...