A5027483351- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Inflammatory mediators and NSAID effects
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis of β-Lactam Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Activity
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- Photosynthetic Processes and Mechanisms
- Analytical Chemistry and Chromatography
- Phytochemistry and Bioactivity Studies
- Enzyme function and inhibition
- HIV/AIDS drug development and treatment
- Crystallization and Solubility Studies
- Microtubule and mitosis dynamics
- Carbohydrate Chemistry and Synthesis
- Research on Leishmaniasis Studies
- Phytochemistry and Bioactive Compounds
Beni-Suef University
2016-2025
Cairo University
2013
In an effort to develop safe and potent anti-inflammatory agents, a series of novel 4'-fluoro-2'-hydroxychalcones 5a-d their dihydropyrazole derivatives 6a-d was prepared. It synthesized via aldol condensation 4'-fluoro-2'-hydroxyacetophenone with appropriately substituted aldehydes followed by cyclization hydrazine hydrate. All the compounds were evaluated for antioxidant, anti-inflammatory, cyclooxygenase inhibition selectivity analgesic activities. The dimethoxychalcone 5a its derivative...
Flutamide is a potential antineoplastic drug classified as an anti-androgen. It therapy for men with advanced prostate cancer, administered orally after which it undergoes extensively first pass metabolism in the liver production of several metabolites. These metabolites are predominantly excreted urine. One important plasma 4-nitro-3-(trifluoromethyl)phenylamine (Flu-1), while main metabolite urine 2-amino-5-nitro-4-(trifluoromethyl)phenol (Flu-3). In this work two metabolites, Flu-1 and...
Aim: The undeniable indomethacin potency has always suffered serious obstacles such as gastric damage. Continuous attempts to develop potent yet safe analogs have never ceased. Results: Herein are new indole derivatives 4a-h and 5a-c, which were synthesized via Fisher reaction, evaluated for both their in vivo anti-inflammatory activities using rat paw edema method vitro cyclooxygenase inhibitory activities. Then ulcerogenic liability, physicochemical parameters molecular docking modeling...
New indomethacin analogs 4a-g, 5, 6, 8a, and 8b were synthesized to overcome the nonselectivity ulcer liability of indomethacin. All newly compounds more potent against cyclooxygenase 2 (COX-2; IC50 value range: 0.09-0.4 μМ) as compared with celecoxib (IC50 = 0.89 μМ). Compounds 4a, 4b, 4d, 6 showed highest COX-2 selectivity index (SI range 4.07-6.33) 1.14) 3.52). Additionally, 7 good anti-inflammatory activity edema inhibition (79.36-88.8%), relative (78.96%) (90.43%), after 5 h. Also,...
Background: Three new series of coumarin derivatives 4a-e, 6a-d and 7a-d were synthesized characterized by elemental analyses spectral data including 2D NMR. All compounds evaluated for their in vitro antioxidant anticancer activity against Hep-G2 hepatic cancer MCF-7 breast cell lines. Keywords: Coumarin, pyrazole, isoxazole, thiazole, antioxidant, anticancer.
In this study new sulphamethoxazole derivatives (S1-S4, S6-S12, and S14-S22) were designed synthesized their structures fully characterized validated using NMR, mass, IR spectroscopy, as well elemental analyses. All (S1-S22) assayed against human carbonic anhydrase (hCAs IX XII) for inhibitory activities. hCAs XII chosen due to the fact that CAIX expression is recognized a hypoxia marker with poor prognosis in breast cancer. When compared Dorzolamide HCl standard reference, S2, S3, S8, S9,...
Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold series (3-benzoxazole-2-yl) phenylamine derivatives, 3-benzoxazoloyl acetamide, butyramide derivatives. Methods. These analogs were synthesized in straightforward simple chemistry without any quantitative chromatographic separations reasonable yields. The evaluation...