Mesoporous silica nanoparticles (MSNs) represent one of the most promising drug delivery systems. MSNs have attracted considerable attention in recent years both industry and biomedicine due to their unique properties. Thus, evaluation toxic effects is necessary before biomedical clinical applications. We investigated vivo effect on production reactive oxygen species (ROS), antioxidant defenses histology heart lung. Rats received 25, 50, 100 200 mg/kg body weight synthesized...

Mesoporous silica nanoparticles (MSNs) represent a promising inorganic platform for multiple biomedical applications. Previous studies have reported MSNs-induced hepatic and renal toxicity; however, the toxic mechanism remains unclear. This study aimed to investigate nephrotoxicity test hypothesis that altered TLR4/MyD88/NF-κB, JAK2/STAT3, Nrf2/ARE/HO-1 signaling pathways mediate oxidative stress, inflammation, fibrosis induced by MSNs. Rats were administered 25, 50, 100, 200 mg/kg MSNs 30...

N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It found in more than 600 different over-the-counter and prescription medicines. Its long-term overdose use highly toxic may result liver injury. Thus, this study was designed to assess preventive effects suggest mechanisms of action navel orange peel hydroethanolic extract, naringin, naringenin APAP-induced hepatotoxicity male Wistar rats. APAP administered rats at a dose level 0.5 g/kg body weight...

Paclitaxel is a primary chemotherapy agent that displays antitumor activity against variety of solid tumors. However, the clinical effectiveness drug hampered by its nephrotoxic and cardiotoxic side effects. Thus, this investigation aimed at assessing protective effects rutin, hesperidin, their combination to alleviate nephrotoxicity caused paclitaxel (Taxol), cardiotoxicity in male Wistar rats, as well oxidative stress. Rutin (10 mg/kg body weight), hesperidin mixture were given orally...

This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity cardiotoxicity in adult male Wistar rats. Intraperitoneal injection paclitaxel 2 mg/kg body weight, two days/week 2nd 5th days each week, with or without oral administration and/or 10 weight every other day, was continued for six weeks. Treatment rats significantly reversed elevated serum creatinine, urea, uric acid levels caused by paclitaxel, reflecting improved kidney function....

This study was designed to assess the nephroprotective effects of Pleurotus ostreatus and Agaricus bisporus aqueous extracts carvedilol on hyperoxaluria-induced urolithiasis scrutinize possible roles NF-κB, p53, Bcl-2, Bax Bak. Phytochemical screening GC-MS analysis mushrooms’ were also performed revealed presence multiple antioxidant anti-inflammatory components. Hyperoxaluria induced in Wistar rats through addition 0.75% (v/v) ethylene glycol drinking water for nine weeks. The...

Broiler chickens are frequently infected with Escherichia coli (E. coli), which often results in disease and high economic losses. The most affected ages to infections E. from 4 5 weeks. Several studies show that poultry already persistently by O157. current study aimed determine the pathogenicity of serogroup O157 broiler chicks, a trial prevention treatment using probiotic and/or antibiotic. chicks were divided into five groups including control negative, positive, treated group,...

Paclitaxel, one of the most effective chemotherapeutic drugs, is used to treat various cancers but it exceedingly toxic when long-term and can harm liver. This study aimed see if rutin, hesperidin, their combination could protect male Wistar rats against paclitaxel (Taxol)-induced hepatotoxicity. Adult were subdivided into 5 groups (each six rats). The normal group was orally given equivalent volume vehicles for 6 weeks. paclitaxel-administered control received intraperitoneal injection at a...

This research aimed to evaluate the preventing effects of naringin, naringenin, and their combination on liver injury induced by Taxol (paclitaxel) in Wistar rats. Male rats received 2 mg/kg intraperitoneal injections twice weekly second fifth days each week for 6 weeks. During same period as administration, were given or a two (10 b.wt) every other day. Treatment with naringin and/or naringenin reduced abnormally high serum levels total bilirubin, aspartate transaminase, alanine alkaline...

Abstract Background and aim Deleterious cutaneous tissue damages could result from exposure to thermal trauma, which be ameliorated structurally functionally through therapy via the most multipotent progenitor bone marrow mesenchymal stem cells (BM-MSCs). This study aimed induce burns examine effect of BM-MSCs during a short long period therapy. Material methods Ninety albino rats were divided into three groups: group I (control); II (burn model), animals exposed preheated aluminum bar at...

Metal oxide nanoparticles are currently used widely in many aspects of human and animal life with broad prospects for biomedical purposes. The present work was carried out to investigate the effects orally administrated TiO2NPs, ZnONPs, IONs Al2O3NPs on mRNA expression level CYP 1A1 NBN rat liver. Four groups male Albino rats were given their respective treatment 60 days a dose 1/20 LD50 TiO2NPs (600 mg/Kg b.wt/day), ZnONPs (340 (200 mg/kg b.wt/day) (100 fifth group served as control group....

Abstract Background Thyroid hormones (THs) regulate growth, development and function of different tissues. Hypothyroidism is a common clinical disorder characterized by deficiency in THs adversely affects the functions several organs. This work aimed to investigate ameliorative effect eltroxin (ELT), hypothyroidism medication, hesperidin (HSP), flavonoid, against testicular renal toxicity hypothyroid rats. Twenty-four rats were divided into four groups treated orally for 12 weeks. Group I...

Nanotechnology has shown a remarkable progress nevertheless, there is growing concern about probable neurotoxic and neurodegenerative effects due to NPs exposure. Various toxicological epidemiological studies reported that the brain main target for ultrafine particles. Brain inflammation considered as possible mechanism can participate effects. Whether nanoparticles (NPs) may produce neurotoxicity promote largely unstudied. The present study was done investigate whether intranasal...

Abstract A high prevalence (86.7%) of various species nematodes was observed in the stomach great cormorants living Lake Biwa, Japan. There were varying numbers adults belonging to two common genera, Eustrongylides Jagerskiold 1909 (Nematoda: Dioctophymatidae ) and Contracaecum Railliet & Henry 1912 Anisakidae). The first included adenophorean comprising a single species, tubifex second comprised ascaroid that contained four named species: rudolphii Hartwich, 1964, microcephalum...

New indomethacin analogs 4a-g, 5, 6, 8a, and 8b were synthesized to overcome the nonselectivity ulcer liability of indomethacin. All newly compounds more potent against cyclooxygenase 2 (COX-2; IC50 value range: 0.09-0.4 μМ) as compared with celecoxib (IC50 = 0.89 μМ). Compounds 4a, 4b, 4d, 6 showed highest COX-2 selectivity index (SI range 4.07-6.33) 1.14) 3.52). Additionally, 7 good anti-inflammatory activity edema inhibition (79.36-88.8%), relative (78.96%) (90.43%), after 5 h. Also,...