The adequate functioning of the maternal thyroid gland plays an important role to ensure that offspring develop normally. Thus, hypo- and hyperthyroidism are used from gestation day 1 lactation 21, in general, recognize alleged association abnormalities associated with different status. In rats during pregnancy lactation, hypothyroidism one group was performed by antithyroid drug, methimazole (MMI) added drinking water at concentration 0.02% other induced exogenous thyroxine (T4) (from 50...

Abstract Excessive concentrations of free radicals in the developing brain may lead to neurons maldevelopment and damage death. Thyroid hormones (THs) states play an important role affecting modulation oxidative stress antioxidant defense system. Thus, objective this study was clarify effect hypothyroidism hyperthyroidism rat dams on development different regions their offspring at several postnatal weeks relation changes The adult female rats were administered methimazole (MMI) drinking...

This study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant effects of Citrus reticulata (C. reticulata) fruit peel hydroethanolic extract two flavonoids, hesperidin quercetin, in nicotinamide (NA)/streptozotocin- (STZ-) induced type 2 diabetic rats. In addition, GC-MS HPLC-MS analyses were performed results indicated presence multiple flavonoids including hesperidin, naringin, polymethoxylated flavones (nobiletin tangeretin). To achieve aim study, rats with...

N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It found in more than 600 different over-the-counter and prescription medicines. Its long-term overdose use highly toxic may result liver injury. Thus, this study was designed to assess preventive effects suggest mechanisms of action navel orange peel hydroethanolic extract, naringin, naringenin APAP-induced hepatotoxicity male Wistar rats. APAP administered rats at a dose level 0.5 g/kg body weight...

The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, rats were treated via the oral route with and (50 mg/kg) either alone or combination every other day for five weeks concomitant receiving intraperitoneal DXR (2 two times a week successive weeks. Quercetin, rutin, their significantly improved deteriorated serum AST, ALT, ALP activities total bilirubin level, as well albumin, AFP,...

Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS cytokines during phase (first day) in streptozotocin (STZ)-diabetic healing. This study designed assess effect WP on metabolic status, inflammation anti-inflammation response, oxidative stress antioxidant defense system different phases process rats. at dosage 100 mg/kg body...

Background: Recently, several research studies have been focused on the isolation and function of polysaccharides derived from different algal species, which revealed multiple biological activities such as antioxidant antitumor activities. This study assesses possible breast cancer chemopreventive properties common seaweeds, sea lettuce, Ulva lactuca (ulvan) using in vitro bioassays human cell line (MCF-7) an vivo animal model carcinogenesis. Methods: Cytotoxic effect ulvan MCF-7 was tested...

This study is aimed at evaluating the preventive effect and suggesting mode of actions naringin hesperidin their combination in diclofenac-induced hepatotoxicity. Male Wistar rats, intraperitoneally injected with diclofenac sodium (3 mg/kg b.wt/day), were orally treated (20 b.wt/day) for 4 weeks. The administrations to diclofenac-injected rats led a significant decrease elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-α, IL-17 levels as well liver lipid peroxidation p53 caspase-3...

Hepatocellular carcinoma (HCC) has been identified as one of the most deadly malignancies with limited therapeutic efficacy worldwide. However, understanding molecular mechanisms crosstalk between signaling pathways in HCC and predicting cancer cell responses to targeted interventions remain be challenge. Thus, this study, we aimed evaluate anticancerous Silybum marianum total extract (STE), silymarin (Sm), silibinin (Sb) against experimentally-induced rats. In vitro investigations were also...

Abstract The antagonistic side effects of chemical medications led to the search for safe strategies such as biogenic agents. Correspondingly, this study aims create biogenic, appropriate, auspicious and innovative therapeutic agents like Galaxaura elongata {GE} , Turbinaria ornata {TO} Enteromorpha flexuosa {EF} macroalgae-based silver nanoparticles (Ag-NPs). Ag + reduction creation Ag[GE]-NPs, Ag[TO]-NPs Ag[EF]-NPs have been validated using UV–visible spectroscopy, Fourier transform...

Paclitaxel is a primary chemotherapy agent that displays antitumor activity against variety of solid tumors. However, the clinical effectiveness drug hampered by its nephrotoxic and cardiotoxic side effects. Thus, this investigation aimed at assessing protective effects rutin, hesperidin, their combination to alleviate nephrotoxicity caused paclitaxel (Taxol), cardiotoxicity in male Wistar rats, as well oxidative stress. Rutin (10 mg/kg body weight), hesperidin mixture were given orally...

Jatropha curcas seed was fed to six calves at doses of 2.5, 1 and 0.25 g/kg once two other 0.025 up 14 days. The onset toxic manifestations in the rapid death occurred within 19 hours administration. that received daily lowest dose J. showed signs poisoning died 10 clinical diarrhoea, dyspnoea, dehydration loss condition were well correlated with pathological findings. There an increase aspartate aminotransferase, ammonia potassium a decrease total protein calcium serum jatropha-poisoned calves.

Objective: This study was designed to assess the anti-proliferative and apoptotic effects of ulvan polysaccharides in vivo using Ehrlich ascites carcinoma (EAC)-bearing mice model vitro hepatocarcinoma cell lines (HepG2) colon (HCT116). Methods:In vivo, polysaccharide orally administered EAC-bearing at dose level 100 mg/ kg b. w. for 2 weeks beginning from 1 st day EAC-intraperitoneal transplantation compared with a control given vehicle.The expressed anti-apoptotic protein Bcl2,...