A5006536839- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Bacterial Genetics and Biotechnology
- Antibiotic Use and Resistance
- Endodontics and Root Canal Treatments
- Salmonella and Campylobacter epidemiology
- Plant Pathogens and Fungal Diseases
- Dental Anxiety and Anesthesia Techniques
- RNA and protein synthesis mechanisms
- Mycotoxins in Agriculture and Food
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Aquaculture disease management and microbiota
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Ocular Infections and Treatments
- Plant and fungal interactions
Misr University for Science and Technology
2015-2025
Sun Yat-sen University
2019-2022
Xinxiang Medical University
2021
Ministry of Education of the People's Republic of China
2021
Inserm
2015
Aix-Marseille Université
2015
Institut de Recherche pour le Développement
2015
Méditerranée Infection Foundation
2015
Centre National de la Recherche Scientifique
2015
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2015
The global dissemination of colistin resistance encoded by mcr-1 has been attributed to extensive use in livestock, threatening efficacy medicine. emergence common pathogens, such as Escherichia coli, is particular concern. China banned the animal feed from May 1, 2017. We investigated subsequent changes prevalence animals, humans, food, and environment, genomic epidemiology mcr-1-positive E coli (MCRPEC).Sampling was done before (October December, 2016) after 2017, 2018, respectively) ban....
CRKP has been registered in the critical priority tier by World Health Organization and become a significant menace to public health. The emergence of CR-HvKP is great concern terms both disease treatment.
Bloodstream infections (BSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are potentially life-threatening and an urgent threat to public health. The present study aims clarify the characteristics of carbapenemase-encoding virulent plasmids, their interactions with host bacterium. A total 425 Kp isolates were collected from blood BSI patients nine Chinese hospitals, between 2005 2019. Integrated epidemiological genomic data showed that ST11 ST307 associated nosocomial...
Background: As a result of the growing prevalence plasmid-mediated mobile colistin resistance gene mcr-1 among Gram-negative bacteria, surveillance mc r- 1 has been globally applied. In our study, we aimed to shed light on possibility transmission -resistant isolates through market retail fruits. Methods and results: Herein, 133 different fruit surface samples were collected screened for MCR variants ( mcr-8 ) using PCR confirmed with sequencing. We identify first time -carrying Escherichia...
Purpose: The discovery of the plasmid-mediated colistin resistance genes, mcr, revealed a mechanism transmission resistance, which is major, global public health concern especially among individuals infected with carbapenem-resistant Gram-negative bacteria. To monitor spread and epidemiology mcr convenient reliable method to detect genes in clinical isolates needed, primary care institutions. This study aimed establish restriction endonuclease-based multiplex loop-mediated isothermal...
Abstract Background The dissemination of multi-drug-resistant bacteria, particularly Methicillin-resistant Staphylococcus aureus (MRSA), necessitates exploring new alternatives for their control. Bacteriophages are promising antibiotic with unique features. Here, we have performed a comprehensive characterization newly isolated bacteriophage (PSK) and compared its therapeutic potential vancomycin in vivo. Methods Sewage samples were processed enriched the MRSA S. SK1 strain search isolation...
The main objective of this study was to decipher the molecular mechanism resistance carbapenems and aminoglycosides in a large series 150 Acinetobacter baumannii clinical isolates collected from July 2012 September 2013 Egypt. We report for first time emergence bla(NDM-1) cooccurrence 16S rRNA methylase armA with bla(OXA-23) Egyptian hospitals. Multilocus sequence typing identified 27 distinct types, 11 which were novel.
Bloodstream infection (BSI) caused by carbapenem-resistant Enterobacteriaceae are potentially life-threatening related to poorer outcomes. Colistin is considered one of the last-resort treatments against human infections multidrug-resistant (MDR) Gram-negative bacteria. Therefore, emergence strains from blood that co-harboring mcr and carbapenem resistance genes were as a serious problem.In this study, two mcr-9-harboring MDR Enterobacter cloacae isolates BSI034 BSI072 recovered BSI patients...
Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) causes serious infections with significant morbidity and mortality. However, the epidemiology transmission mechanisms of CR-hvKP corresponding carbapenem-resistant plasmids require further investigation. Herein, we have characterized an ST11 strain EBSI041 from blood sample encoding both hypervirulence carbapenem resistance phenotypes a patient in Egypt.K. showed multidrug-resistance phenotypes, where it was highly resistant to...
Clostridioides difficile, which causes life-threatening diarrheal disease, presents an urgent threat to health care systems. In this study, we present a retrospective genomic and epidemiological analysis of C. difficile in large teaching hospital. First, collected 894 nonduplicate fecal samples from patients during whole year elucidate the molecular epidemiology. We then presented detailed description population structure based on 270 isolates separated between 2015 2020 clarified genetic...
Purpose: The main objective of this study was to decipher the prevalence, antimicrobial resistance, major virulence genes and molecular characteristics methicillin-resistant Staphylococcus aureus (MRSA) isolated from different clinical sources in southern China. Materials methods: present performed on 187 non-duplicate S. isolates collected three tertiary hospitals Guangdong Province, China, 2010–2016. Antimicrobial susceptibility testing by disk diffusion method measuring minimum inhibitory...
Introduction and aim: Chlorhexidine Hydrochloride [Chx.HCl] has a broad-spectrum antibacterial effect, sustained action low toxicity so it been recommended as potential root canal irrigant. The aim of this study was to improve the penetration ability, cleansing effect Chx.HCl using newly formulated nanoemulsion use Methods: nanoemulsions were prepared two different oils; Oleic acid Labrafil M1944CS, surfactants; Tween 20 80 co-surfactant; Propylene Glycol. Pseudoternary phase diagrams...
There is growing evidence that GreA aids adaptation to stressful environments in various bacteria. However, the functions of among mycobacteria remain obscure. Here, we report on cellular consequences following deletion greA gene Mycobacterium spp. The mutant strain (ΔgreA) was generated smegmatis, tuberculosis H37Ra, and H37Rv. Deletion results growth retardation poor survival response adverse stress, besides rendering M. more susceptible vancomycin rifampicin. By using RNA-seq, observe...
Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR quasipneumoniae isolate a patient bloodstream infection were identified to carry tmexCD1-toprJ1 The addition of the efflux pump inhibitor reduced tigecycline MIC against all three by 8- 16-fold. pKQBSI104-1 was transferred K. Escherichia coli J53 via conjugation. tmexCD1-toprJ1-carrying plasmids pKP15ZE495-1 (102,569 bp) (121,996 completely sequenced analyzed.
The emergence and transmission of the mobile colistin resistance gene (mcr-1) threatened extensive use polymyxin antimicrobials. Accumulated evidence showed that banning additive in livestock feed efficiently reduce mcr-1 prevalence, not only animals but also humans environments. However, our previous study has revealed a small proportion Escherichia coli could continually carry chromosomally-encoded mcr-1. events, indicated existence stabilized heritage potential threat antimicrobial...
In response to the spread of colistin resistance gene mcr-1, China banned use in livestock fodders. We used a time-series analysis inpatient colonization data from 2011-2019 accurately reveal associated fluctuations mcr-1 that occurred inpatients ban.
Aeromonas dhakensis is an important ubiquitous Gram-negative and freshwater bacterium detected in different reservoirs. It can cause invasive diseases humans. Herein, we report the first case Mainland China of a fulminant death 29-year-old man as result new, unexpected association between septicemic A. hepatitis B viral infection (HBV). patient died from multiple organ failure 5 d postadmission after ingestion Snakehead Fish meal. The isolated was initially misidentified hydrophila using...
Previous studies reported the prevalence of mcr-1 among clinical infected Salmonella isolates in China. However, transmission dynamics different ecological niches were not well investigated. Our objective is to exhibit Salmonella. 598 recovered from ten hospitals; besides 936 pig faces and 167 pork samples collected January 2015 December 2017 Guangzhou, PCR sequencing used identify mcr-1-positive Antimicrobial susceptibility testing was performed with 16 antimicrobials. Conjugation, S1-PFGE,...
Introduction and Aim: Sodium hypochlorite (NaOCl) has proven to be the chosen irrigator in modern practice due its high tissue solution power, antibacterial, lubricant properties.This study aimed use a Lipid-Free Nanoemulsion (LF/NE) improve penetration efficiency, antibacterial effect, dissolving, cleansing ability of NaOCl.Moreover, masking NaOCl taste when used as root canal irrigant.Methods: LF/NE were comprised mixture surfactants (Tween20 Tween 80) cosolvents (Transcutol HP propylene...
Abstract Background The global dissemination of colistin resistance encoded by mcr-1 has been attributed to extensive use in livestock, threatening efficacy medicine. emergence common pathogens, such as Escherichia coli , is particular concern. Therefore, China banned the animal feed from May 1 ST 2017. We investigated subsequent changes prevalence, and genomic epidemiology -positive (MCRPEC). Methods Sampling was conducted pre- (October-December 2016) post-colistin ban (October-December,...