A5064516480- Cytokine Signaling Pathways and Interactions
- Kawasaki Disease and Coronary Complications
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Herpesvirus Infections and Treatments
- Renal and related cancers
- Coronary Artery Anomalies
- Pediatric health and respiratory diseases
- Parkinson's Disease Mechanisms and Treatments
- Psoriasis: Treatment and Pathogenesis
- Antibiotic Resistance in Bacteria
- Digestive system and related health
- Cardiovascular Health and Risk Factors
- Inflammasome and immune disorders
- Birth, Development, and Health
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Polyamine Metabolism and Applications
- Reproductive System and Pregnancy
- Tea Polyphenols and Effects
- RNA regulation and disease
Shanghai Jiao Tong University
2020-2023
China Medical University
2018-2022
Fourth Affiliated Hospital of China Medical University
2018-2022
Johns Hopkins Medicine
2022
Johns Hopkins University
1999-2022
Kunming University of Science and Technology
2022
Shenzhen Children's Hospital
2020-2021
Sun Yat-sen University
2019
Chinese Academy of Agricultural Sciences
2019
Shanghai First People's Hospital
2016
Background: As a result of the growing prevalence plasmid-mediated mobile colistin resistance gene mcr-1 among Gram-negative bacteria, surveillance mc r- 1 has been globally applied. In our study, we aimed to shed light on possibility transmission -resistant isolates through market retail fruits. Methods and results: Herein, 133 different fruit surface samples were collected screened for MCR variants ( mcr-8 ) using PCR confirmed with sequencing. We identify first time -carrying Escherichia...
Smad proteins are transcription activators that critical for transmitting transforming growth factor-β (TGF-β) superfamily signals from the cell surface receptors to nucleus. Our previous studies have shown cellular polyamines essential normal intestinal mucosal and a decreased level of inhibits epithelial proliferation, at least partially, by increasing expression TGF-β/TGF-β receptors. The current study went further determine possibility Smads downstream intracellular effectors activated...
Hypoxia can lead to stabilization of the tumor suppressor gene p53 and cell death. However, mutations could promote survival in a hypoxic environment. In this study, we found that p53N236S (p53N239S humans, hereinafter referred as p53S) mutant mouse embryonic fibroblasts (MEFs) resistant deferoxamine (DFO) mimic Further, Western blot flow cytometry showed reduced apoptosis p53S/S cells compared WT after DFO treatment, suggesting an antiapoptosis function p53S mutation response...
Human cytomegalovirus (HCMV) is a ubiquitous pathogen belongs to betaherpesvirus subfamily. RNA2.7 highly conserved long non-coding RNA accounting for more than 20% of total viral transcripts. In our study, functions HCMV were investigated by comparison host cellular transcriptomes between cells infected with clinical strain and deleted mutant. It was demonstrated that polymerase II (Pol II)-dependent gene transcriptions significantly activated when removed during infection. A 145...
Children born to women who experience stress during pregnancy have an increased risk of atherosclerosis in later life, but few animal models explored mechanisms. To study this phenomenon, timed-bred ApoE knockout mice were determined pregnant with ultrasound and randomly assigned on gestation day 8.5 either a control (no stress) or prenatal (PS) group using 2 h restraint for five consecutive days. PS significantly plasma corticosterone levels mice. The litters from showed neonatal mortality...
The phospholipase C (PLC) is a family of kinases that hydrolyze phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] to generate two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which stimulate distinct downstream signaling.Recently, it has been reported PLC signaling activated by multiple viruses for efficient replication the virus-induced inflammatory response.In this study, we demonstrated PLC-specific inhibitor U73122 strongly suppressed porcine...
Abstract Background : Kawasaki disease (KD) is the main cause of acquired heart in children and can lead to coronary artery lesions. This present study was designed analyze characteristics KD peripheral blood mononuclear cells (PBMC) through single-cell RNA sequecing (scRNA-seq) explore potential molecular mechanism KD. Methods: PBMC collected from one healthy child patient, used sequencing for cell clusters identification differently expressed gene (DEG) determination. GO function...
Objective To discuss the effects of bacteria lysates(OM-85BV), 1, 25 - dihydroxy vitamin D3 [1, 25-(OH)2-VitD3], two immune regulators on airway inflammation in asthmatic mice models, and its pathways action were discussed. Methods Forty male BALB/c graded 4-6 weeks randomly divided into 5 groups.Group A: control group; group B: model C: 25-(OH)2-VitD3 D: OM-85BV E: combination group.On days 0 to 14, C, D E groups given 25-(OH)2-VitD3, 25-(OH)2-VitD3+ OM-85BV, A, B 9 g/L saline...
To determine the types and proportion of common hemoglobin variants in Tianjin surrounding areas, to analyze recognition ability effects on experimental results two commonly used glycated systems, so as provide data support for consistency HbA1c detection City. A case-control study was retrospective analysis,156 specimens with abnormal electrophoretic peaks were collected from more than 50 000 patients Chu Hsien-I Memorial Hospital Medical University between June 2020 December 2020....
Abstract Human cytomegalovirus (HCMV) is a ubiquitous pathogen belongs to the beta herpesvirus family. RNA2.7 viral long non-coding RNA accounting for more than 20% of total transcripts at early time infection. By construction deleted mutant and genome transcriptomic analysis, demonstrated repress host cellular polymerase II (Pol II)-dependent transcription through inhibiting phosphorylation II). Co-immunoprecipitation, immunoprecipitation electrophoretic mobility shift assay are followed...
Abstract Background: Kawasaki disease (KD) isan acute self-limiting systemic vasculitis.In this study, a randomized controlled trial regarding berberine (main component of CoptidisRhizoma) function in treating KD was carried out and possible pharmacological mechanisms CoptidisRhizoma (CR) on therapy were investigated using an integrated network pharmacology approach. Results: The BBR group able to reduce the values CRP, NLR PLR significantly. Also, effect improved resistance rate intravenous...
Abstract Background: Kawasaki disease (KD) is an acute self-limiting systemic vasculitis. In study, a randomized controlled trial regarding berberine (main component of Coptidis Rhizoma) function in treating KD was carried out and possible pharmacological mechanisms Rhizoma (CR) on therapy were investigated using integrated network pharmacology approach. Methods: A total 58 children with KD, younger than 5 years old, enrolled the study from October 2018 to May 2019. The patients randomly...