A5040046800- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Protein Degradation and Inhibitors
- Gestational Diabetes Research and Management
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Prenatal Screening and Diagnostics
- Ubiquitin and proteasome pathways
- Skin Protection and Aging
- Phytoestrogen effects and research
- Tea Polyphenols and Effects
- Geothermal Energy Systems and Applications
- BRCA gene mutations in cancer
- Ferroptosis and cancer prognosis
- Occupational and environmental lung diseases
- MicroRNA in disease regulation
Kunming University of Science and Technology
2012-2025
North China Electric Power University
2023-2025
Xinxiang Medical University
2024
Xiangtan University
2022-2024
Zoucheng People's Hospital
2024
Xinxiang University
2024
Kunming University
2021
Laboratory of Molecular Genetics
2017
Treating Idiopathic pulmonary fibrosis (IPF) remains challenging owing to its relentless progression, grim prognosis, and the scarcity of effective treatment options. Emerging evidence strongly supports critical role accelerated senescence in alveolar epithelial cells (AECs) driving progression IPF. Consequently, targeting senescent AECs emerges as a promising therapeutic strategy for Curcumin analogue EF24 is derivative curcumin shows heightened bioactivity encompassing anti-inflammatory,...
Abstract Senescent cells (SnCs) are implicated in aging and various age‐related pathologies. Targeting SnCs can treat diseases extend health span. However, precisely tracking visualizing of is still challenging, especially vivo environments. Here, we developed a near‐infrared (NIR) fluorescent probe (XZ1208) that targets β‐galactosidase (β‐Gal), well‐accepted biomarker for cellular senescence. XZ1208 be cleaved rapidly by β‐Gal produces strong fluorescence signal SnCs. We demonstrated the...
Accumulating evidence indicates that the increased burden of senescent cells (SCs) in aged organisms plays an important role many age-associated diseases. The pharmacological elimination SCs with "senolytics" has been emerging as a new therapy for age-related diseases and extending healthy lifespan. In present study, we identified cycloastragenol (CAG), secondary metabolite isolated from Astragalus membrananceus, delays symptoms mice through its senolytic activity against SCs. By screening...
Summary Coats plus ( CP ) is a rare autosomal recessive disorder caused by mutations in CTC 1, component of the CST STN and TEN 1) complex important for telomere length maintenance. The molecular basis how impact upon remains unclear. 1 L1142H mutation has been previously shown to disrupt In this study, we used CRISPR /Cas9 engineer into both alleles HCT 116 RPE cells demonstrate that 1: interaction required repress telomerase activity. interacts poorly with leading telomerase‐mediated...
Abstract Human shelterin components POT1 and TPP1 form a stable heterodimer that protects telomere ends from ATR-dependent DNA damage responses regulates telomerase-dependent extension. Mice possess two functionally distinct proteins. POT1a represses ATR/CHK1 the alternative non-homologous end-joining repair pathway while POT1b C-strand resection recruits CTC1-STN1-TEN1 (CST) complex to telomeres mediate fill-in synthesis. Whether are involved in regulating length of telomeric G-strand is...
Polysaccharides derived from edible mushrooms were sources of new prebiotic compounds. Limited studies their effects, as well the presence residual dark colors, impede use prebiotics in food industry. To boost value polysaccharides mushroom Ramaria flava, a decolorization method, and physicochemical characterization potential decolorized polysaccharide (DRFP) investigated this study. The reversed micelle system consisting n-hexanol/isooctane (3:7, v/v) 200 mM surfactant (CTAB) was an...
Pu-erh tea is a kind of fermented with the incorporation microorganisms' metabolites. Unlike green tea, chemical characteristics and bioactivities are still not well understood. Using water extracts we analyzed tumor cell growth inhibition activities on several genetically engineered mouse lines. We found that at concentration did affect wild type embryo fibroblasts (MEFs) growth, could inhibit by down-regulated S phase cause G1 or G2 arrest. Further study showed expression mutant p53 in...
p53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies have produced conflicting results concerning role codon 72 polymorphism (G>C) on risk cancer; therefore, meta-analysis was performed to estimate association between Screening PubMed database conducted identify relevant studies. containing available genotype frequencies were selected pooled odds ratio (OR) with 95% confidence interval (CI) used assess association. Sixty-one published studies,...
Si Jun Zi Tang (SJZT) is a classic Traditional Chinese Medicine (TCM) prescription used to treat aging-related diseases. However, the potential molecular mechanisms of anti-aging effects bioactive compounds and their targets remain elusive. In this study, we combined network pharmacology docking with in vivo experiments elucidate mechanism SJZT. A series strategies were predict therapeutic SJZT, including compound screening, pathway enrichment analysis studies. Based on predictions...
Human Werner syndrome (WS) is an autosomal recessive progeria disease. A mouse model of WS manifests the disease through telomere dysfunction-induced aging phenotypes, which might result from cell cycle control and cellular senescence. Both p21 Waf1/Cip1 (p21, encoded by Cdkn1a gene) p16 Ink4a (p16, are inhibitors involved in regulating two key pathways To test effect deficiencies WS, we crossed mice (DKO) with –/– or to construct triple knockout (p21-TKO p16-TKO) mice. By studying survival...
Aberrant methylation of the breast cancer susceptibility gene 1 (BRCA1) promoter is a mechanism for its functional inactivation. It may potentially be used as prognostic marker in studies patients with and plays an important role tumorigenesis. Numerous have suggested that BRCA1 associated prognosis cancer. However, different ethnicities remains ambiguous. The present meta-analysis was performed to adjust augment previously published study, which estimated correlations between clinical...
Chronic stable angina (CSA) is a cardiovascular disease with high prevalence. At present, drug treatment still the main measure of pectoris. Traditional Chinese medicine has long history in CSA. Qi stagnation and Blood stasis syndrome common Xinnaoning (XNN) capsule considered as an effective adjuvant for CSA efficacy promoting qi blood circulation but lack high-quality clinical evidence. The purpose this study to evaluate safety XNN compared placebo by trial.This multicenter, randomized,...