A5013881588- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Collagen: Extraction and Characterization
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Polydiacetylene-based materials and applications
- Telomeres, Telomerase, and Senescence
- Cellular Mechanics and Interactions
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Advanced Materials and Mechanics
- Medical and Biological Sciences
Shanghai Institute of Materia Medica
2023
Chinese Academy of Sciences
2023
Chongqing University
2015-2022
A growing body of evidence has shown that extracellular matrix (ECM) stiffness can modulate stem cell adhesion, proliferation, migration, differentiation, and signaling. Stem cells feel respond sensitively to the mechanical microenvironment ECM. However, most studies have focused on classical two-dimensional (2D) or quasi-three-dimensional environments, which cannot represent real situation in vivo. Furthermore, current methods used generate different properties invariably change fundamental...
Bone-derived ECM (bECM)-incorporated nanofibrous scaffold is capable of promoting osteogenic differentiation mesenchymal stem cells (MSCs), mitigating the foreign-body reaction, and accelerating bone regeneration in a defected rat skull.
Abstract Senescent cells (SnCs) are implicated in aging and various age‐related pathologies. Targeting SnCs can treat diseases extend health span. However, precisely tracking visualizing of is still challenging, especially vivo environments. Here, we developed a near‐infrared (NIR) fluorescent probe (XZ1208) that targets β‐galactosidase (β‐Gal), well‐accepted biomarker for cellular senescence. XZ1208 be cleaved rapidly by β‐Gal produces strong fluorescence signal SnCs. We demonstrated the...
Consisting of seed cells and scaffold, regenerative medicine provides a new way for the repair regeneration tissue organ. Collagen/hydroxyapatite (HA) biocomposite scaffold is highlighted due to its advantageous features two major components bone matrix: collagen HA. The aim this study investigate effect internal structure collagen/HA on fate rat mesenchymal stem (MSCs). was characterized by micro-CT. It found that porosity decreased while average compressive modulus increased with increase...
Although mild photothermal therapy (mild-PTT) avoids treatment bottleneck of the traditional PTT, application mild-PTT in deep and internal tumors is severely restricted due to thermal resistance, limited irradiation area penetration depth. In addition, bone resorption caused by tumor colonization distal tissue exacerbates progression. Here, an innovative strategy was developed for metastasis alleviation resorption, which based on liquid metal (LM) nanoparticle resist resistance induced via...