A5082827291- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Silk-based biomaterials and applications
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nerve injury and regeneration
- Cell Adhesion Molecules Research
- Knee injuries and reconstruction techniques
- Advanced Sensor and Energy Harvesting Materials
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- CAR-T cell therapy research
- Ultrasound and Hyperthermia Applications
- Tendon Structure and Treatment
- Thermoregulation and physiological responses
- Extracellular vesicles in disease
- Tunneling and Rock Mechanics
Wuhan Textile University
2022-2025
Renmin Hospital of Wuhan University
2025
Wuhan University
2025
Advanced Processing Technology (United States)
2022-2025
Zhongkai University of Agriculture and Engineering
2025
Northwest University
2020-2024
CCCC Highway Consultants (China)
2022
Chongqing University
2012-2021
Northwest University
2020
Shandong University of Science and Technology
2015-2016
A growing body of evidence has shown that extracellular matrix (ECM) stiffness can modulate stem cell adhesion, proliferation, migration, differentiation, and signaling. Stem cells feel respond sensitively to the mechanical microenvironment ECM. However, most studies have focused on classical two-dimensional (2D) or quasi-three-dimensional environments, which cannot represent real situation in vivo. Furthermore, current methods used generate different properties invariably change fundamental...
The combination of nerve guide conduits (NGCs) and electrical stimulation (ES) is an effective treatment for peripheral injury (PNI). Flexible conductive materials with mechanical properties similar to those biological tissues have been shown better long-term biointegration functionality than rigid materials. In this study, liquid metal (LM)-based polycaprolactone/gelatin/polypyrrole/LM (PCL/Gel/PPy/LM, PGPL) NGC was combined exogenous ES repair PNI. PGPL membranes had good hydrophilicity,...
Abstract Stiffness tunable advanced materials have demonstrated their superiority and versatility in diverse areas, while the global pursuit of reversible, intelligent, fast response for stiffness regulation is growing radically, leaving great challenges traditional materials. As newly emerging functional metal material, low melting point alloys (LMPAs) shown encouraging potential developing various strategies owing to excellent physicochemical mechanical properties. This article dedicated...
Induced pluripotent stem cells (iPSCs) hold great potential for cell therapy and tissue engineering. Neural crest (NCSCs) are multipotent that capable of differentiating into mesenchymal lineages. In this study, we investigated whether iPSC-derived NCSCs (iPSC-NCSCs) have tendon repair. Human iPSC-NCSCs were suspended in fibrin gel transplanted a rat patellar window defect. At 4 weeks post-transplantation, macroscopical observation showed the repair iPSC-NCSC-treated tendons was superior to...
As a biophysical cue, matrix stiffness can decide the stem cell fate. However, most methods to construct three-dimensional (3D) scaffolds may change 3D microstructure while altering their mechanical properties. In this study, demineralized bone with different compressive modulus (66.06 ± 27.83 MPa (high), 26.90 13.16 (medium), and 0.67 0.14 (low)) were constructed by controlling decalcification duration (1 h, 12 5 days), respectively. The pore size porosity have no significant difference...
In the three-dimensional (3D) tumor microenvironment, matrix stiffness is associated with regulation of cells behaviors. vitro models appropriate are urgently desired. Herein, we prepare 3D decellularized extracellular (DECM) scaffolds different to mimic microenvironment human breast tissue, especially stiffness, components and structure ECM. Furthermore, effects on drug resistance cancer explored these developed as case studies. Our results confirm that DECM diverse can be generated by...
Abstract Vascularization and innervation play irreplaceable roles in bone regeneration defect repair. However, the reconstruction of blood vessels neural networks is often neglected material design. This study aims to design a genetically functionalized matrix (GFM) enable it regulate angiogenesis neurogenesis accelerate process The dual small interfering RNA (siRNA)‐polyvinylimide (PEI) (siRP) complexes that locally knocked down soluble vascular endothelial growth factor receptor 1 (sFlt‐1)...
This study was conducted to evaluate the effects of dietary sodium butyrate (SB) supplementation on antioxidant status, intestinal morphology, functional damage, and barrier integrity heat-stressed Hy-Line Sonia (HYS) layer chicks. A total 240 female HYS at 35 days age with average body weights (415 ± g) were divided into 6 groups 10 replicates/group 4 chickens per replicate. 2 × 3 factorial design performed, including two conditions ambient temperature (25 °C °C) three levels SB (0, 0.5,...
Early life experience modulates resilience to stress in later life. Previous research implicated maternal care as a key mediator of behavioral responses the adversity adolescence, but details molecular mechanisms remain elusive. Here, we show social activates transcription factor C/EBPβ mPFC neurons adolescent mice, which transcriptionally upregulates Dnm1l and promotes mitochondrial dysfunction, thereby conferring susceptibility mice. Moreover, different separation differentially regulates...