A5100376847- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Chronic Myeloid Leukemia Treatments
- Mesenchymal stem cell research
- Cardiovascular Disease and Adiposity
- Fibroblast Growth Factor Research
- Retinoids in leukemia and cellular processes
- Ovarian cancer diagnosis and treatment
- Sperm and Testicular Function
- Endometrial and Cervical Cancer Treatments
- CRISPR and Genetic Engineering
- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Land Use and Ecosystem Services
- Eosinophilic Disorders and Syndromes
- Aquaculture disease management and microbiota
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-related skin toxicity
- Bone Metabolism and Diseases
- Biological Stains and Phytochemicals
Nanjing University
2024
Xiangtan University
2024
Sichuan Agricultural University
2020-2023
City University of Hong Kong
2023
University of Notre Dame
2023
Chongqing Medical University
2012-2022
Shanghai Children's Medical Center
2016-2021
Shanghai Jiao Tong University
2020-2021
Dana-Farber Cancer Institute
2021
Harvard Stem Cell Institute
2021
Previous studies have indicated that bone morphogenetic protein 9 (BMP9) can promote the osteogenic differentiation of mesenchymal stem cells (MSCs) and increase formation in diseases. However, mechanisms involved remained poorly understood. It is necessary to investigate specific regulatory were induced by BMP9. During process BMP9, expression microRNA-155 (miR-155) exhibited a tendency increasing at first then decreasing, which made us consider miR-155 may modulatory role this process, but...
Selective inhibition of BCR/ABL expression by RNA interference has been demonstrated as an effective strategy in CML treatment and a reversal to imatinib resistance. microRNAs (miRNAs) are small regulatory RNAs involved post-transcriptional gene regulation. miR-203 is supposed directly regulate ABL expression, however, the role imatinib-resistant cells not clear. Here, we report that overexpression BaF3-BCR/ABL with T315I mutant inhibited cell growth colony formation ability. Furthermore,...
Bone morphogenetic proteins (BMPs), particularly BMP9, have been shown to promote the osteogenic differentiation of murine multilineage cells (MMCs) and bone formation in diseases; however, mechanisms involved remain poorly understood. MicroRNAs (miRNAs or miRs) proven regulate mesenchymal stem cell (MSC) differentiation. In this study, we identified a novel mechanism that unravels functional axis key miRNA (miR-21) which contributes BMP9‑induced We screened differentially expressed miRNAs...
Abstract Extravasation of circulating cancer cells determines their metastatic potential. This process is initiated by the adhesion to vascular endothelial through specific interactions between receptors such as E-selectin and ligands on cells. In present study, we show that miR-146a miR-181b impede expression repressing activity its transcription factor NF-κB, thereby impairing potentials colon decreasing to, migration through, endothelium. Among two microRNAs, only activated IL-1β,...
// Liang Zhong 1 , Bryan Simoneau Jacques Huot Martin J. Simard St-Patrick Research Group in Basic Oncology, CHU de Québec-Université Laval Centre (Hôtel-Dieu Québec), University Cancer Centre, Quebec City, Québec, G1R 2J6, Canada Correspondence to: Huot, email: Jacques.Huot@fmed.ulaval.ca Simard, Martin.Simard@crchudequebec.ulaval.ca Keywords: c-Fos, c-Jun, GATA2, IL-1β metastasis, endothelial cells Received: April 06, 2016 Accepted: October 31, Published: December 02, ABSTRACT...
Graft acceptance without the need for immunosuppressive drugs is ultimate goal of transplantation therapy. In murine liver transplantation, allografts are accepted across major histocompatibility antigen complex barriers use and constitute a suitable model research on immunological rejection tolerance. MicroRNA (miRNA) has been known to be involved in responses. order identify mRNAs spontaneous allograft tolerance, miRNA expression hepatic was examined using this model. According graft...
Nitrogen from ammonia is one of the most common pollutants toxics to aquatic species in environment. The intestinal mucosa key mucosal defenses species, and accumulation nitrogen water environment will cause irreversible damage function. In this study, histology, immunohistochemistry, ultrastructural pathology, enzyme activity analysis qRT-PCR were performed reveal toxic effect stress on intestine Pelteobagrus fulvidraco. According histological findings, caused structural reduced number...
Increasing evidence revealed that miRNAs, the vital regulators of gene expression, are involved in various cellular processes, including cell growth, differentiation, apoptosis and progression. In addition, miRNAs act as oncogenes and/or tumor suppressors. The present study aimed to verify potential roles miR148b human renal cancer cells. miR‑148b was found be downregulated cancel tissues lines. Functional studies demonstrated plasmid‑mediated overexpression promoted proliferation, increased...
Abstract Previous studies have suggested that microRNAs (miRNAs) are associated with the progression of myocardial ischemic reperfusion (I/R) injury. However, inconsistent results been obtained due to differences in sequencing platform, control selection, and filtering conditions. To explore key miRNAs pathogenesis I/R injury develop miRNA diagnostic biomarkers for prevention, we performed a systematic analysis publicly available expression data investigated function signature miRNA. A total...
Neutrophil elastase (NE) is a neutrophil‑derived serine proteinase with specificity for broad range of substrates. NE has been reported to be associated the pathogenesis several conditions, particularly that pulmonary diseases. Previous studies have shown can cleave pro‑myelocyte ‑ retinoic acid receptor‑alpha chimeric protein and important development acute pro‑myelocytic leukemia. To further elucidate role in leukemia, present study successfully constructed lentiviral vector containing...
Abstract Background This study was designed to determine the effect of human umbilical cord multipotent mesenchymal stromal cells (hUC-MSC) on acute ischemia/reperfusion (I/R) injury spermatogenic cells. Method The testicular I/R rat model established through 720° torsion for 1 h. hUC-MSC were intravenously injected 10 min before detorsion. Injury severity estimated by Johnsen’s score. proliferating recipient spermatogonia measured immunostaining antibodies against Ki67, and all germ...
Although previous studies have shown that stem cells can be differentiated into Leydig by gene transfection, a simple, safe and effective induction method has not yet been reported. Therefore, the present study investigated novel methods for of human umbilical cord mesenchymal cell (HUMSC) differentiation Leydig-like, steroidogenic cells. HUMSCs were acquired using tissue block culture attachment method, expression MSC surface markers was evaluated flow cytometry. obtained enzymatic...
MicroRNA (miRNA) are significant regulators of neuropathic pain development and neuroinflammation can contribute a lot to the progression pain. Recently, miR-98 has been reported be involved in various diseases. However, little is known about role neuroinflammation. Therefore, our study was aimed investigate function via establishing rat model using chronic constriction injury (CCI) sciatic nerve. Here, we observed that downregulated CCI models. Overexpression miR-9 able inhibit progression....
MicroRNAs (miRNA) play important roles in neuroinflammation and neuropathic pain development; however, the underlying mechanism requires further investigation. The expression of miR-21-5p was remarkably upregulated chronic constrictive injury (CCI) rat model. A significant alleviated development reduced cytokines observed CCI after exogenous injection mimic. dual-luciferase analysis revealed that tissue inhibitor metalloproteinase-3 (TIMP3) chemokines C-C motif ligand 1 (CCL1) direct...
Crustaceans have a more persistent starvation tolerance than mammals, birds, reptiles, and even fish. This study is aimed at assessing the survival strategy regulatory mechanism of crustaceans in response to through an animal model using Eriocheir sinensis . In 42-day experiment, hepatopancreas was found become target organ, which characterized by atrophy thin wall hepatic tubules expansion lumen. During short-term starvation, E. activates lipid glycogen metabolism with dominating....
Abstract The long-noncoding RNA colorectal neoplasia differentially expressed (CRNDE) gene has been considered to be crucial in tumor malignancy. Although CRNDE is highly acute myeloid leukemia (AML), its mechanism of action remains unknown. In this study, GEPIA and qRT-PCR were performed confirm the expression AML samples cell lines, respectively. shRNA vectors transfected explore biological functions CRNDE. proliferation was assessed by CCK8 assay, while apoptosis cycle distribution...
Abstract Long non-coding RNAs (lncRNA) play a key role in the orchestration of transcriptional regulation during development and many other cellular processes. The importance regulatory co-expression network was highlighted identification mechanism these processes humans mice. However, elucidation properties porcine lncRNAs involved pre-implantation embryonic fibroblast reprogramming to induced pluripotent stem cell (iPSC) has been limited date. Using weighted gene analysis, we constructed...