A5101856342- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Platelet Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Cytomegalovirus and herpesvirus research
- Peptidase Inhibition and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pregnancy and preeclampsia studies
- Digestive system and related health
- Glycosylation and Glycoproteins Research
- Protein Tyrosine Phosphatases
- Ferroptosis and cancer prognosis
- RNA regulation and disease
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Biliary and Gastrointestinal Fistulas
- Vascular Anomalies and Treatments
- Advanced Glycation End Products research
Shandong Provincial Hospital
2014-2024
Shandong First Medical University
2024
Tongren Hospital
2024
Shanghai Jiao Tong University
2022-2024
Zhengzhou University
2014-2022
Wuhan University of Science and Technology
2011-2022
Zhongnan Hospital of Wuhan University
2021-2022
The First People’s Hospital of Lianyungang
2021-2022
Henan Provincial People's Hospital
2020-2022
Indiana University – Purdue University Indianapolis
2022
Signal transducer and activator of transcription 3 (STAT3) controls cell survival, growth, migration, invasion. Here, we observed that STAT3 exerted anti-apoptotic effects in breast cancer cells. On the other hand, miR-17-5p induced apoptosis cells, overexpression sensitized MCF-7 cells to paclitaxel-induced via STAT3. Overexpression decreased apoptosis, but knockout abolished miR-17-5p-induced increases apoptosis. Finally, promoted by increasing p53 expression, which was inhibited These...
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), serving as the viral persistence form and transcription template of HBV infection, hijacks host histone non-histone proteins to a minichromosome utilizes posttranslational modifications (PTMs) "histone code" for its transcriptional regulation. X protein (HBx) is known cccDNA activator. In this study we established dual system inducible reporter cell lines modelling infection with wildtype (wt) HBx-null HBV, both secreting...
HER2-positive breast cancer was aggressive, resulting in a poorer prognosis. This multicenter study analyzed the real-world data of women treated with pyrotinib-based therapy, aiming to describe their characteristics, treatment regimens, and investigate clinical outcomes.A total 141 patients were enrolled from February 2019 April 2020. Last follow-up time 2021. All therapy 21-day cycles. The primary endpoint progression-free survival (PFS).The median PFS (mPFS) for 12.0 months (95%CI...
Baicalin has been used as mainly bioactive constituent of about 100 kinds traditional Chinese medicines in pharmacopoeia. The effect baicalin on cytochrome P450 should be paid more attention because was widely. aim this study to investigate whether could inhibit CYP1A2 pooled human liver microsomes (HLMs) and rats vivo the gene polymorphisms affect inter-individual variation IC50 28 livers. Phenacetin probe CYP1A2. Kinetic parameter each sample were measured common (−3860G>A −163C>A)...
Objective To investigate the accuracy of preoperative computed tomography (CT), magnetic resonance (MR) imaging and diffusion-weighted with background body signal suppression (DWIBS) in prediction nodal involvement primary rectal carcinoma patients absence tumor invasion into pelvic structures. Methods Materials Fifty-two subjects cancer were preoperatively assessed by CT MRI at 1.5 T a phased-array coil. Preoperative lymph node staging modalities (CT, MRI, DWIBS) compared final histological...
Background PTPRD, encoding protein tyrosine phosphatases receptor type D, is located at chromosome 9p23–24.1, a loci frequently lost in many types of tumors. Recently, PTPRD has been proposed to function as tumor suppressor gene. The current study aimed investigate expression and its prognostic significance primary gastric adenocarcinoma. Methods Results Quantitative real time reverse transcription PCR (qRT-PCR) western blotting were used examine paired tumourous paracancerous tissues....
Abnormal expression of O-Linked β-N-acetylglucosamine (O-GlcNAc) and β-catenin is a general feature cancer contributes to transformed phenotypes. In this study, we identified the interaction between O-GlcNAc β-catenin, explored their effects on progression liver cancer. Our results demonstrated that upregulation was induced by high glucose, whereas application PuGNAc GlcNAc increased protein levels, as well protein's stability nuclear accumulation in cell lines HEP-G2 HuH-7. addition,...
Microvesicles (MVs) derived from human umbilical cord mesenchymal stem cells (hUC-MSCs-MVs) and miR-21 were demonstrated to ameliorate renal ischemia-reperfusion injury (IRI). Since hUC-MSC-MVs contained a substantial quantity of miR-21, we speculated that might account for part the therapeutic effects hUC-MSCs-MVs. The tubule epithelial (HK-2) cultured under low oxygen (LO) condition mimic cellular IRI model. A rat model unilateral was established. co-culture HK-2 MSC-MVs utilized examine...
Abstract Although there are many studies on the relationship between genetic polymorphisms and incidence of diseases, mechanisms rarely known. We report mechanism by which signal transducer activator transcription 4 ( stat4 ) rs7574865 promotes occurrence progression hepatocellular carcinoma (HCC). found that GG genotype at was a risk genotype, STAT4 levels in serum peritumoral tissue from HCC patients with were significantly higher than those TT or TG carriers. Furthermore, elevated had...
Epidermal growth factor (EGF) and insulin-like factor-I (IGF-I) are critical regulators of cell differentiation, survival, proliferation, migration in cancers. This study found that ARNO (cytohesin-2), an activator the EGF IGF-I pathways, was more highly expressed colorectal cancer tissue than benign adjacent tissue. When ARNO-siRNA or chemical inhibitor SecinH3 blocked ARNO, downstream pathways decreased lines HT29 HCT116. blocking also weakened invasion, vitro. Furthermore, receptor...
Background Pyrotinib, a small-molecule tyrosine kinase inhibitor, has been investigated as component of neoadjuvant therapy in phase 2 trials human epidermal growth factor receptor (HER2)-positive breast cancer. This study aimed to evaluate the effectiveness and safety pyrotinib-containing for patients with HER2-positive early or locally advanced cancer real-world setting. Methods Data 97 from 21 centers across China treated were reviewed. Neoadjuvant consisted taxane/carboplatin/trastuzumab...
Cytohesins have been identified as cytoplasmic ErbB receptor activators in certain cancers, exhibiting an important role signaling. However, whether cytohesins are essential colorectal cancer is unknown. The aim of the present study was to investigate contribute epidermal growth factor (EGF) pathway cells. RT‑PCR and immunofluorescence experiments were employed detect expression cell lines. EGF activation conditions investigated by examining phosphorylation (EGFR) intracellular...
Human cytomegalovirus immediate early proteins (CMV IEs) are involved in transcriptional activities of both host and virus gene expression. This study shows that the activity myocardin regulating cardiomyocyte hypertrophy is enhanced by co-expressing CMV IE2. Forced expression IE2 increases augmented cell size neonatal rat cardiac myocytes induced myocardin, as well mRNA protein levels hypertrophic genes, whereas deletion CArG boxes atrial natriuretic factor (ANF) promoter attenuates effect...