A5114860419- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Mechanisms of cancer metastasis
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Heat shock proteins research
- Genomics, phytochemicals, and oxidative stress
- Connexins and lens biology
- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- Genetic and Kidney Cyst Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Fibroblast Growth Factor Research
- Hippo pathway signaling and YAP/TAZ
- RNA regulation and disease
Wuhan University of Science and Technology
2016-2024
Northwest A&F University
2024
Huazhong University of Science and Technology
2023
Zhongnan Hospital of Wuhan University
2023
Huzhou University
2023
Wuhan University
2023
Peking University
2021
Peking University People's Hospital
2021
First People's Hospital of Foshan
2010
miR-5100 participates in the proliferation of lung cancer and pancreatic cells, differentiation osteoblasts. However, regulation gastric cells remains unclear. The blood patients was collected to detect expression level miR-5100, apoptosis autophagy levels were detected using western blot, flow cytometry, confocal. At same time, vitro tumor formation experiments nude mice used verify results experiments. is related prognosis cancer, can enhance inhibit occurrence by targeting CAAP1. MKL1...
Signal transducer and activator of transcription 3 (STAT3) controls cell survival, growth, migration, invasion. Here, we observed that STAT3 exerted anti-apoptotic effects in breast cancer cells. On the other hand, miR-17-5p induced apoptosis cells, overexpression sensitized MCF-7 cells to paclitaxel-induced via STAT3. Overexpression decreased apoptosis, but knockout abolished miR-17-5p-induced increases apoptosis. Finally, promoted by increasing p53 expression, which was inhibited These...
Tumor cells metabolize more glucose to lactate in aerobic or hypoxic conditions than normal cells. Pyruvate kinase isoenzyme type M2 (PKM2) is crucial for tumor cell glycolysis. We established a role let-7a-5p/Stat3/hnRNP-A1/PKM2 signaling breast cancer metabolism. PKM2 depletion via small interfering RNA (siRNA) inhibits proliferation and glycolysis Signal transducer activator of transcription 3 (Stat3) promotes upregulation heterogeneous nuclear ribonucleoprotein (hnRNP)-A1 expression,...
Abstract The long noncoding RNA H19 is overexpressed in many cancers and acts as an oncogene. Here, we explored the role of breast cancer cells, including effect on proliferation, migration, invasion cells. We also investigated relation to microRNA miR‐93‐5p signal transducers activators transcription 3 (STAT3), target gene miR‐93‐5p. Ectopic expression MCF‐7 cells knockdown MDA‐MB‐231 showed that overexpression promoted invasion, whereas reduced vitro. Dual‐luciferase reporter assays...
CAR T-cell therapy is well tolerated and effective in patients with Hodgkin lymphoma (HL) anaplastic large cell (ALCL). However, even second- generation anti-CD30 T-cells CD28 (28z) costimulatory domains failed to achieve the desired rate of complete responses. In present study, we developed second-generation (CD28z) third-generation (CD28BBz) targeting CD30 investigated their efficacy vitro vivo. Both CD28z CD28BBz T cells were similar regarding amplification, subsets distribution,...
Multiple new subtypes of breast cancer (BRCA) are identified in women each year, rendering BRCA the most common and rapidly expanding form females globally. NUF2 has been as a prognostic factor various human cancers, regulating cell apoptosis proliferation. However, its role prognosis not clarified. This study explored development using informatic analysis combined with vivo intracellular studies. Through online website TIMER, we evaluated transcription profile across variety different types...
Although many methods and new therapeutic drugs have been developed, the overall survival rate long-term of patients with gastric cancer (GC) are still not satisfactory. In this study, we investigated effects microRNA miR-133a-3p transcription factor FOXP3 on proliferation autophagy GC cells their interactions. Our results showed that knockdown increased cells. The relationship between has reported previously. addition, could directly bind promoter region TP53 inhibit its expression. via...
DEK and miR-5100 play critical roles in many steps of cancer initiation progression are directly or indirectly regulated by most promoters repressors. LEF1-AS1 as a long non-coding RNA can regulate tumor development through sponge miRNA. The effect regulatory mechanism on autophagy apoptosis gastric (GC), the role between still unclear. Our study found that was highly expressed tissues cell lines, knockdown inhibited cells, promoted apoptosis, suppressed malignant phenotype cancer. regulates...
Cervical cancer ranks fourth in women terms of incidence and mortality. The RNA-binding protein YTH N6-methyladenosine F2 (YTHDF2) contributes to progression by incompletely understood mechanisms. We show how YTHDF2 controls the fate cervical cells whether could be a valid target for therapy cancer. Sphere formation alkaline phosphatase staining assays were performed evaluate tumor stemness following knockdown. Apoptosis was detected flow cytometry TUNEL assay. compounds 4PBA SP600125 used...
High temperatures are considered one of the most significant limitations to subtropical fishery production. Largemouth bass (
Lung adenocarcinoma is a malignant and fatal respiratory disease. However, due to its complex pathogenesis poorly effective therapeutic options, accurate early diagnosis prognosis remain elusive. Now, there increasing evidence that tumor stem cells are involved in tumorigenesis, metastasis, relapse, resistance chemotherapy radiotherapy one of the reasons why tumors cannot be cured. The mRNA expression based-stemness index (mRNAsi) parameter obtained by Malta his colleagues applying...
Currently commercialized CAR-T cell therapies targeting CD19 and BCMA show great efficacy to cure B malignancies. However, intravenous infusion of these cells severely destroys both transformed normal in most tissues organs, particular lung, leading a critical question that what the impact depletion on pulmonary diseases lung cancer is. Herein, we find frequency is remarkably reduced smoking carcinogen-treated tumors, which associated with advanced progression worse patient survival. by...
Thyroid cancer remains the most common endocrine malignancy worldwide, and its incidence has steadily increased over past four years. Papillary Cancer (PTC) is differentiated thyroid cancer, accounting for 80-85% of all cancers. Mitochondrial proteins (MRPs) are an important part structural functional integrity mitochondrial ribosomal complex. It been reported that MRPL9 highly expressed in liver promotes cell proliferation migration, but it not PTC. In present study we found was PTC tissues...
Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for progression breast cancer and also pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in cancer. The role MKL-1s DNMT1 migration still unclear. MKL-1 (myocardin related factor A) can bind conserved cis-regulatory element CC (A/T) 6GG (called CarG box) promoter regulate miR-142-5p. expressions miR-142-5p are positively correlated. In addition, it has been...
Gastric cancer poses a serious threat to human health and affects the digestive system. The lack of early symptoms dearth effective identification methods make diagnosis difficult, with many patients only receiving definitive at malignant stage, causing them miss out on optimal therapeutic interventions. Melanoma-associated antigen-A (MAGE-A) is part MAGE family falls under cancer/testis antigen (CTA) category. MAGE-A subfamily plays significant role in tumorigenesis, proliferation...
Although great progress has been achieved in cancer treatment the past decades, lung remains leading cause of death, which is partially caused by fact that most cancers are diagnosed at advanced stages. To improve sensitivity and specificity diagnosis, underlying mechanisms current diagnosis methods urgent need to be explored. Herein, we find expression EpCAM, widely used molecular marker for tumor cell characterization isolation, strongly upregulated primary tumors, both gene amplification...
Abstract Myocardin is frequently repressed during human malignant transformation, and restoration of myocardin expression in sarcoma cells contributes to the inhibition growth. However, its role breast carcinoma has barely been addressed. Here, we reported that could inhibit proliferation MCF‐7 cells. Notably, show inhibited ERα‐mediated cancer via impairing ER‐dependent transcriptional activation, mainly through activity ERα. Importantly, molecular mechanism for transcription ERα‐induced...
Bladder cancer (BLCA) is one of the common malignant tumors urinary system. The poor prognosis BLCA patients due to lack early diagnosis and disease recurrence after treatment. Increasing evidence suggests that gene products nuclear factor activated T-cells (NFAT) family are involved in progression subsequent interaction(s) with immune surveillance. In this study, we carried out a pan-cancer analysis NFAT found NFAT2 an independent prognostic for BLCA. We then screened differentially...