A5101839609- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Metal complexes synthesis and properties
- Medical Research and Treatments
- Ferrocene Chemistry and Applications
- Immunotherapy and Immune Responses
- Synthesis and Biological Evaluation
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Central Venous Catheters and Hemodialysis
- Acupuncture Treatment Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Protease and Inhibitor Mechanisms
- Biochemical effects in animals
- FOXO transcription factor regulation
- Barrier Structure and Function Studies
Anhui University
2025
Peking University People's Hospital
2023-2024
Peking University
2023-2024
Sun Yat-sen University
2024
Shaoxing University
2023
Shanghai University
2023
Sichuan University
2019-2022
Chongqing Medical University
2022
Shandong First Medical University
2021
Shandong University
2011-2015
Non-small-cell lung cancer (NSCLC) is the leading cause of tumor-related death in humans. Radiotherapy a crucial strategy for NSCLC treatment, although its effectiveness limited by radio-resistance tumor cells. Our current research finds that protein arginine methyltransferase 7 (PRMT7) upregulated and correlates with poor prognosis. Pharmacological inhibition PRMT7 SGC3027, specific small-molecule inhibitor, suppresses proliferation, migration invasion NSCLC. Combining irradiation SGC3027...
To study the efficacy and safety of autologous transplantation bone marrow mesenchymal stem cells on diabetic patients with lower limb ischemia. Fifty Type 2 ischemia were enrolled randomized to either transplanted group or control group. Patients in both received same conventional treatment. Meanwhile, 20 ml from each patient collected, separated by density gradient centrifugation cultured medium serum. After three-weeks adherent culture vitro, 7.32×108–5.61×109 harvested multiple...
Leukemia stem cells (LSC) represent a crucial and rare subset of present in acute myeloid leukemia (AML); they play pivotal role the initiation, maintenance, relapse this disease. Targeting LSC holds great promise for preventing AML improving long-term outcomes. However precise molecular mechanisms governing self-renewal are still poorly understood. Here, we compelling evidence that expression miR-30e-5p, potential tumor-suppressive microRNA, is significantly lower samples than healthy bone...
This work represents the first example of interception a di-heteroatom ylide through an S N 1-type process, enabling multicomponent trifunctionalization Rh-carbynoids.
Mechanical stimulation induces bone growth and remodeling by the secondary messenger, cyclic guanosine 3’, 5’-monophosphate (cGMP), in osteoblasts. However, role of cGMP regulation estrogen biosynthesis, whose deficiency is a major cause osteoporosis, remains unclear. Here, we found that prenylated flavonoids, 3- O -methoxymethyl-7- -benzylicaritin (13), 7- (14), 4'- -methyl-8-isopentylkaempferol (15), which were synthesized using icariin analogs, promoted biosynthesis osteoblastic UMR106...
The protective role of miR-488 in cerebral neurons has been identified previously. However, whether is involved acute ischemia stroke not reported. current study aims to investigate the expression peripheral blood ischemic patients.Seventy-six patients with were selected as case group, which included 33 cases aortic atheromatous plaque, 19 cardioembolism, 16 small arterial occlusion, and 8 unknown cause. Sixty healthy subjects control group. RT-PCR was used detect patients. NIHSS score...
Abstract We report a dual‐responsive, self‐assembled nano micelle for co‐delivery of doxorubicin (DOX) and previously reported cyclopalladated anti‐cancer agent (CP). In this system, CP were electrostatically complexed to form hydrophobic core while conjugation polyethylene glycol β ‐cyclodextrin (CD) was designed construct the hydrophilic out‐layer stabilize micelle. The interaction between pegylated CD DOX‐CP composite achieved via inclusion ferrocene moiety by CD, which could be broken...
To analyze the etiology and risk factors of central venous catheter (CVCs) infections, to explore prophylaxis treatment for catheter-related infections.A retrospective study was conducted. The patients with CVCs admitted intensive care unit (ICU) Qianfoshan Hospital Affiliated Shandong University from January 2000 December 2016 were enrolled. gender, age, data microorganism culture results all collected. infection rate incidences per 1 000 days calculated. analyzed by Logistic regression.1...
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Abstract Helios was related to the immunosuppressive capacity and stability of regulatory T cells. However, significance in follicular help (TFH) (TFR) cells is unclear. This research aimed clarify ( IKZF2 ) TFH TFR its clinical value systemic lupus erythematosus (SLE). mRNA different cell subsets analyzed. Helios+ percentages were identified peripheral blood 75 SLE patients 62 HCs (healthy controls). PD-1 ICOS expression compared between Helios− The secrete IL-21 IL-10 measured. Correlation...
Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer, and early detection diagnosis this disease are crucial in reducing mortality rates. The timely LUAD essential for controlling tumour development enabling surgical treatment. GPR56 a vital G protein-coupled receptor its role T lymphocytes has received considerable attention. However, function B cells remains unclear. This study aimed to investigate significance LUAD. We found that exhibited significant increase...
Dysfunction of calcium channels is involved in the development and progression some cancers. However, it remains unclear role channel inhibitors tumor immunomodulation. Here, blocker lacidipine identified to potently inhibit enzymatic activity expression indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme tryptophan metabolism. Lacidipine activates effector T cells incapacitates regulatory (Tregs) augment anti-tumor effect chemotherapeutic agents breast cancer by converting...