A5101590179- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Effects of Environmental Stressors on Livestock
- Meat and Animal Product Quality
- Animal Genetics and Reproduction
- Reproductive Physiology in Livestock
- RNA modifications and cancer
- Heat shock proteins research
- Milk Quality and Mastitis in Dairy Cows
- Adipose Tissue and Metabolism
- Selenium in Biological Systems
- RNA Research and Splicing
- Infant Nutrition and Health
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Blockchain Technology Applications and Security
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Crop Yield and Soil Fertility
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Video Analysis and Summarization
- Microbial Metabolic Engineering and Bioproduction
- Complement system in diseases
Anhui University
2025
Guangxi University
2024
Guangxi University of Chinese Medicine
2024
Guangdong Academy of Medical Sciences
2020-2024
Guangdong Provincial People's Hospital
2020-2024
Shantou University
2021-2024
Shantou University Medical College
2021-2024
Langfang Normal University
2017-2023
Taishan University
2022-2023
National Clinical Research
2023
The posttranscriptional gene regulation mediated by microRNA plays an important role in the development and function of male female reproductive organs germ cells mammals, including cattle.In present study, we identified novel differentially expressed miRNAs testis ovary Holstein cattle combining Solexa sequencing with bioinformatics.In total 100 104 pre-miRNAs were testicular ovarian tissues, encoding 122 136 mature miRNAs, respectively.Of these, 6 appear to be bovine-specific.A 246 known...
MicroRNAs (miRNAs) are a class of small noncoding RNAs that play important roles in the regulation gene expression. However, role miRNAs bovine mammary gland responses to heat stress is not well understood. In present study, we performed deep RNA sequencing analysis identify associated with potential gland. We identified 27 were differentially expressed significantly between tissue Holstein cattle and normal conditions. Twenty had higher expression heat-stressed cattle. The seven highest...
Non-small-cell lung cancer (NSCLC) is the leading cause of tumor-related death in humans. Radiotherapy a crucial strategy for NSCLC treatment, although its effectiveness limited by radio-resistance tumor cells. Our current research finds that protein arginine methyltransferase 7 (PRMT7) upregulated and correlates with poor prognosis. Pharmacological inhibition PRMT7 SGC3027, specific small-molecule inhibitor, suppresses proliferation, migration invasion NSCLC. Combining irradiation SGC3027...
Heat-shock transcription factors (HSFs) play an important role in regulating heat stress response. The activation of heat-shock protein (HSP) genes is mediated by HSFs, which bind to promoters HSP genes. In this research, two novel single nucleotide polymorphisms, T909C and G4693T, their association with thermal tolerance were investigated 951 Chinese Holstein cattle. Linkage disequilibrium haplotype construction analyzed using SHEsis software. Four haplotypes constructed, nine combinations...
Major histocompatibility complex, class II, DQ alpha 2, also named BOLA-DQA2, belongs to the Bovine Leukocyte Antigen (BOLA) II genes which are involved in immune response. To explore variability of BOLA-DQA2 gene and resistance mastitis cows, splice variants (SV), targeted microRNAs (miRNAs), single nucleotide polymorphisms (SNPs) were identified this study. A new SV (BOLA-DQA2-SV1) lacking part exon 3 (195 bp) two 3′-untranslated regions (UTR) (52 bp+167 was found healthy mastitis-infected...
Two size of nano-scale (40 nm, 60 nm) and one micro-scale (200 silica particles were studied to investigate the possible mechanism cytotoxicity autophagy dysfunction in human bronchial epithelial BEAS-2B cells.
Heat stress has a substantial negative economic impact on the dairy industry. N6-methyladenosine (m6A) is most common internal RNA modification in eukaryotes and plays key role regulating heat response animals. In cows, however, this remains largely unexplored. Therefore, we examined effects of m6A gene expression bovine mammary epithelial cells to elucidate mechanism response. study, Mammary alveolar cells-large T antigen (MAC-T) were incubated at 37 °C (non-heat group, NH) 40 (heat H) for...
The sperm-specific phospholipase C zeta (PLCz) is a candidate sperm-borne oocyte-activating factor that triggers characteristic series of physiological stimuli via cytoplasmic Ca2+ oscillations during fertilization. molecular mechanisms involved in the regulation PLCz gene expression remain largely unknown. To explore genetic variations 5′-flanking region and their common haplotypes Chinese Holstein bulls, as well to determine whether these affect bovine semen quality traits transcriptional...
The mechanisms that dairy cattle respond to environmental stresses are very complicated. Previous research into the molecular of mammalian heat stress has largely focused on role protein-coding genes and small non–coding RNAs. Recently, it become apparent large numbers long non-coding RNAs transcribed from genomes play extensive roles in transcriptional regulation. However, expression lncRNAs their biological functions remain unknown. In this study, we employed a deep RNA sequencing examine...
Summary HMGB 3 (high‐mobility group box 3) is an X ‐linked member of a family sequence‐independent chromatin‐binding proteins and functions as universal sentinel for nucleic acid–mediated innate immune responses. The splice variant expression, promoter characterization targeted micro RNA s the bovine gene were investigated to explore its expression pattern possible regulatory mechanism. results revealed that transcript variants 1 2 ( 3‐ TV ‐ 2) mRNA in mastitis‐infected mammary gland tissues...
Introduction Abrus mollis Hance. (AM) is an important species used in southern Chinese medicine. It mainly found Guangdong and Guangxi provinces China, it effective the treatment of hepatitis. Endophytic bacteria are known to affect growth quality medicinal plants. However, there limited reports describing endophytic related AM. Methods In present study, Illumina-based 16S rRNA gene sequencing was investigate bacterial communities root nodules AM at five sampling sites Guangxi. addition, 179...