A5100378454- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- HVDC Systems and Fault Protection
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Cholesterol and Lipid Metabolism
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Prenatal Screening and Diagnostics
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA and protein synthesis mechanisms
- Acute Myeloid Leukemia Research
- Tumors and Oncological Cases
Wuhan University
2020-2024
Vanderbilt University Medical Center
2024
First Affiliated Hospital of Xi'an Jiaotong University
2012-2024
Renmin Hospital of Wuhan University
2023
Xinjiang Medical University
2023
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
The University of Texas MD Anderson Cancer Center
2017-2022
Langfang Normal University
2022
Hebei North University
2019-2021
Abstract Background N 6 -Methyladenosine (m A) modification has been implicated in many biological processes. It is important for the regulation of messenger RNA (mRNA) stability, splicing, and translation. However, its role cancer not studied detail. Here we investigated underlying mechanism m A hepatoblastoma (HB). Methods We used Reverse transcription quantitative real-time PCR (RT-qPCR) Western blotting to determine expression related factors. And clarified effects these factors on HB...
High-grade serous ovarian cancer (HGSOC) is one of the most common epithelial malignancies. tRNA-derived fragments (tRFs) have been identified as novel potential biomarkers and targets for therapy. Nevertheless, influence tRFs on HGSOC remains unknown. This study aimed to identify HGSOC-associated investigate function mechanism key in SK-OV-3 cells.The tRF profiles patients controls were investigated using small RNA sequencing. Differentially expressed verified by real-time PCR, a was...
Epidemiological and clinical evidence suggests that diabetes increases the risk of liver cancer. Although co-occurrence type 2 (T2D) cancer is becoming more frequent, underlying mechanisms remain unclear. Even though baicalin, extensively used in traditional Chinese medicine (TCM), can control T2D inhibit separately, minimal research available regarding its possible effect on T2D-induced Thus, present study, we aimed to investigate role baicalin hepatocellular cancer, for first time,...
Chronic obstructive pulmonary disease (COPD), a common respiratory disease, can be divided into stable phase and acute exacerbation (AECOPD) is characterized by inflammation hyper-immunity. Methylation of N6-methyladenosine (m6A) an epigenetic modification that regulates the expression functions genes influencing post-transcriptional RNA modifications. Its influence on immune regulation mechanism has attracted great attention. Herein, we present m6Amethylomic landscape observe how...
Post-translational modifications including protein ubiquitination regulate a plethora of cellular processes in distinct manners. RNA N6-methyladenosine is the most abundant post-transcriptional modification on mammalian mRNAs and plays important roles various physiological pathological conditions hematologic malignancies. We previously determined that eraser ALKBH5 necessary for maintenance acute myeloid leukemia (AML) stem cell function, but post-translational involved regulation remain...
Heat stress has a substantial negative economic impact on the dairy industry. N6-methyladenosine (m6A) is most common internal RNA modification in eukaryotes and plays key role regulating heat response animals. In cows, however, this remains largely unexplored. Therefore, we examined effects of m6A gene expression bovine mammary epithelial cells to elucidate mechanism response. study, Mammary alveolar cells-large T antigen (MAC-T) were incubated at 37 °C (non-heat group, NH) 40 (heat H) for...
We aimed at probing impact of LINC00858 on esophageal squamous cell carcinoma (ESCC) progression via ZNF184-FTO-m6A-MYC axis.Expression related genes (LINC00858, ZNF184, FTO, and MYC) was detected in ESCC tissues or cells their relationships were assessed. After expression alterations cells, proliferation, invasion, migration, apoptosis detected. Tumor formation nude mice conducted.LINC00858, MYC overexpressed cells. enhanced ZNF184 to upregulate which augmented expression. knockdown...
Keratin-associated proteins (KAPs) are a diverse group of and form matrix that cross-links keratin intermediate filaments in hair wool fibres. From over 100 KAP genes (KRTAPs) identified mammalian species, KRTAP25-1 is high sulphur (HS)-KAP gene, which has recently been described humans. Here, we report the absence sheep, describe new HS-KRTAP (named KRTAP28-1) chromosome region where was expected to be found. Six variants (A-F) KRTAP28-1 containing eight single nucleotide polymorphisms...
14-kDa Phosphohistidine phosphatase (PHP14), the first histidine protein identified in vertebrates, was recently revealed to play an essential role lung cancer. The function of this gene other tumors is unclear; however, study, we demonstrate that PHP14 highly expressed hepatocellular carcinoma (HCC) tissues and cell lines compared with adjacent non-cancerous human liver cells (P<0.05). We used lentivirus-mediated delivery small interfering RNA (siRNA) knockdown expression HCC line...
Human epididymis protein 4 (HE4) is a novel cancer biomarker. This study evaluates the prognostic role of HE4 in determining survival endometrial patients.Literature search was conducted electronic databases (Embase, Ovid, PubMed, Scopus, and Web Science). Studies were selected if they reported relationship between patients. Random-effects meta-analyses performed to achieve estimates baseline serum levels, 5-year with high low levels/expression, hazard ratios (HRs) patients levels.9 studies...
Background. Modification of N6-methyladenosine (m6A) and RNA m6A regulatory factors is required in cancer advancement. The contribution its alteration esophageal squamous cell carcinoma (ESCC) still unclear. Results. ALKBH5 was lowly expressed ESCC tissues, which the total level increased tissue than presentation normal healthy tissue. pcDNA3.1-ALKBH5 recombinant plasmid transfected into KYSE-150 Eca-109 cells. overexpression responsible for a significant reduction levels KYSE150 cells,...
Amniocentesis was performed on a pregnant woman with deletion of exon 45 the Duchenne Muscular Dystrophy (DMD) gene.Fetal Xp21.1 (31944831-32030363) x 0 found by chromosome microarray analysis (CMA), i.e., 0.086 Mb hemizygote detected in region fetal X chromosome, which contained DMD gene.The results verified MLPA were consistent those CMA, indicated that CMA accurate single this fetus. This case suggests may become an essential method for prenatal diagnosis fetus gene...
Background & Aims: Hepatocellular carcinoma (HCC), the main type of liver cancer, has a high morbidity and mortality rate poor prognosis. RNA helicase DDX5, which acts as transcriptional co-regulator, is overexpressed in most malignant tumors promotes cancer cell activities. Heat shock protein 90 (HSP90) an important molecular chaperone conformational maturation stabilization numerous proteins involved growth or survival.Methods: DDX5 mRNA expression surgically resected HCC tissues from 24...
Abstract Background: The NOTCH1 gene functions as either an oncogene or tumor suppressor in cancer depending upon the type. Our group previously characterized genomic alterations head and neck squamous cell carcinoma (HNSCC), discovering that is frequently altered with a pattern of inactivating mutations suggesting it this However, recent work by others suggests signaling plays more complex role, possibly promoting aggressive phenotype stem cell-like properties HNSCCs wild type NOTCH1....
To investigate the methylation status of PTPL1 in Hut78, Maver, Z138, CA46, Raji and Jurkat cell lines, reversing effect 5-Aza on expression mRNA.The lines were cultured vitro, MS-PCR was used to detect gene RT-PCR mRNA, CCK-8 method determine proliferation, siRNA-mediated silencing clarify role lymphoma lines.PTPL1 promoter non-methylated Maver Z138 cells, hyper-methylated Raji, CA46 cells; different levels mRNA Z138; re-expression resulted from hyper-methylation found cells. The treatment...
<p>This file contains data showing relationship between cdk2 activity and Chk1 inhibition in hypersensitive UMSCC1-mVenus least sensitive HN31-mVenus cells. This is linked to main figure 5.</p>