A5069260538- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Respiratory Support and Mechanisms
- Epigenetics and DNA Methylation
- Medical Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Single-cell and spatial transcriptomics
- Iron Metabolism and Disorders
- Polysaccharides and Plant Cell Walls
Capital Medical University
2020-2025
China Rehabilitation Research Center
2022-2025
Beijing Friendship Hospital
2020-2023
National Clinical Research Center for Digestive Diseases
2021-2023
Zhejiang University
2023
Peking University People's Hospital
2017-2020
Peking University
2017-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Hebei University of Technology
2019
China International Science and Technology Cooperation
2017
Abstract Background The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and the overall survival. However, cells forming TME gastric have not extensively characterized. Results We combine bulk single-cell RNA sequencing from tumors matched normal tissue of 24 treatment-naïve GC better understand which cell types transcriptional programs are associated with malignant transformation stomach. Clustering 96,623...
Epidemiological and clinical evidence suggests that diabetes increases the risk of liver cancer. Although co-occurrence type 2 (T2D) cancer is becoming more frequent, underlying mechanisms remain unclear. Even though baicalin, extensively used in traditional Chinese medicine (TCM), can control T2D inhibit separately, minimal research available regarding its possible effect on T2D-induced Thus, present study, we aimed to investigate role baicalin hepatocellular cancer, for first time,...
Abstract Background Although the relationship between type 2 diabetes (T2D) and increased risk of colorectal carcinogenesis is widely defined in clinical studies, therapeutic methods molecular mechanism T2D-induced colon cancer how does hyperglycemia affect progression still unknown. Here, we studied function lactoferrin (LF) suppressing T2D mice, uncovered related mechanisms DNA 5mC RNA m6A levels. Methods We examined effects LF (50% iron saturation) on migration invasion tumor cells under...
Abstract Colon cancer‐associated transcript‐1 (CCAT1) is a highly conserved long noncoding RNA that deregulated in several cancers. However, its role gastric carcinoma and post‐transcriptional regulation remain poorly understood. In this study, we provide the first evidence CCAT1 regulates miR‐490 cancer (GC) cells. Interestingly, can also repress expression. expression was significantly upregulated, downregulated GC. The negative correlation between observed GC tissues. Importantly,...
Pulmonary rehabilitation is rapidly moving toward personalized, intelligent, and multidisciplinary management in 2024. This review provides a comprehensive overview of the latest advances from October 2023 to September The content includes strategies for common respiratory diseases, innovations optimizations models, updates applications assessment metrics, improvements training methods supportive measures, advancements technologies devices, current challenges. By synthesizing these findings,...
Colorectal cancer (CRC) is one of the leading causes death worldwide. MiR‐382 has been found to have a decreased expression and ability suppress tumorigenesis in certain cancers. However, role miR‐382 CRC not sufficiently investigated. NR2F2 (also known as COUP‐TFII), member steroid/thyroid receptor superfamily, often aberrantly activated various tumors, but it currently unclear whether may be target miR‐382. In present study, we investigated identified regulation by We observed that was...
BACKGROUNDThere is growing evidence proving that many human carcinomas, including colon cancer, can overexpress immunoglobulin (Ig); the non B cancer cell-derived Ig usually displayed unique V(D)J rearrangement pattern are distinct from Ig.Especially, cancer-derived plays important roles in initiation, progression, and metastasis.However, it still remains unclear if display sequencing, which be used as novel target for therapy. AIMTo investigate repertoire features expressed cells.
Currently, no satisfactory targets for colorectal cancer or markers immunotherapy and diagnosis prognosis are available. Immunoglobulin G (IgG) is widely expressed in many cancers, it promotes progression. This study explored the role of cancer-derived IgG (CIgG) cancer.First, using a monoclonal antibody to CIgG, we examined expression levels CIgG cell lines by western blot immunofluorescence analyses tissue specimens immunohistochemistry. Second, variable region gene was amplified nested...
Increasing evidence has shown that abnormal expression of miR-4284 participates in the progression several types cancer. However, and role miR‑4284 gastric cancer remain largely unknown. Therefore, present study levels tissues cell lines, was examined using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) found significantly upregulated 40 pairs five lines compared to corresponding normal GES‑1 line. In addition, increased positively associated with TNM stage (P=0.035),...
OBJECTIVE: This study investigated the potential synergistic effects of two inducers apoptosis: small molecule ABT-737 and arsenic trioxide (ATO). METHODS: Human gastric carcinoma cell lines SGC-7901 MGC-803 were used to determine ATO (alone or in combination) on proliferation apoptosis vitro. In vivo these drugs solid tumours, grown immunodeficient mice. RESULTS: inhibited induced cells concentration- time-dependent manners, showed a effect. disturbed binding B lymphoma (Bcl)-2 homologous...
Lack of protein and vitamin A influences the growth student in impoverished mountain areas. The aim study was to assess effects egg supplementation on hemoglobin, serum retinol anthropometric indices 10-18 years old students a low socioeconomic status. total number 288 from four boarding schools were randomly selected by using cluster sampling method Chongqing, they assigned into supplement group control non-randomly. Students received single 200,000 international units 1 egg/day (including...
Growing evidence indicates a potential role for miR‑490‑3p in tumorigenesis. However, its function colorectal carcinoma (CRC) remains undefined. In this study, was markedly downregulated fifty cancer tissue samples compared with the corresponding adjacent non‑cancerous specimens, by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The expression levels of were closely associated tumor differentiation and distant metastasis. addition, both Kaplan-Meier multivariate...
Increasing evidence has shown that abnormal expression of lncRNAs is involved in various biological behaviors and major cellular pathways human cancers. However, the role progression gastric cancer not been adequately investigated. Therefore, this study, we investigated levels linc-GPR65-1 using Quantitative real-time PCR (qRT-PCR) found was significantly up-regulated 50 tissues compared to corresponding normal tissues. In addition, increased associated with TNM stage (P = 0.037), tumor size...
Advanced gastric cancer (AGC) is a malignant disease with limited therapeutic options and poor prognosis. Recently, immune checkpoint inhibitors (ICIs), represented by of programmed cell death 1 (PD-1)/programmed death-ligand (PD-L1), have emerged as potential (GC) therapy.This case study aimed to reveal the tumor response neoadjuvant chemotherapy combined camrelizumab in patient AGC based on characteristics clinical pathology, genomics variation, gut microbiome. Samples from 59-year-old...
Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in antiangiogenesis which has been an essential strategy for cancer treatment. We report the first-in-human study of AK109, novel anti-VEGFR2 monoclonal antibody, to characterize safety profile and pharmacokinetics/pharmacodynamics (PK/PD) properties, explore preliminary antitumor efficacy patients with solid tumors.This was multicenter, open-label, phase I study, including dose escalation expansion (NCT04547205)....
The current management of advanced gastric or gastro-oesophageal junction adenocarcinoma remains unsatisfactory. We investigated the efficacy and safety combination therapy apatinib S-1, considering potential advantage home-based treatment without hospital admission, in patients with platinum-refractory adenocarcinoma.In this open-label, single-arm, phase 2 trial, each 21-day cycle, eligible received at an initial dose 500 mg once daily continuously S-1 a 40-60 twice on days 1-14 until trail...
The dysregulation of the translation elongation factor families which are responsible for reprogramming mRNA has been shown to contribute tumor progression. Here, we report that acetylation eukaryotic Elongation Factor 1 Alpha (eEF1A1/EF1A1) is required genotoxic stress response and maintaining malignancy colorectal cancer (CRC) cells. evolutionarily conserved site K439 identified as key site. Tissue expression analysis demonstrates level eEF1A1 higher than paired normal tissues. Most...