A5047281555- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Angiogenesis and VEGF in Cancer
- HIV/AIDS drug development and treatment
- Pregnancy and Medication Impact
- Andrographolide Research and Applications
- PARP inhibition in cancer therapy
- Inflammatory mediators and NSAID effects
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
First Affiliated Hospital of Jiangxi Medical College
2023
Jiangxi Provincial People's Hospital
2023
Bristol-Myers Squibb (United States)
2015-2016
Bristol-Myers Squibb (India)
2015
Biocon (India)
2015
Inhibition of organic anion-transporting polypeptide (OATP)1B function can lead to serious clinical drug-drug interactions, thus a thorough evaluation the potential for this type interaction must be completed during drug development. Therefore, sensitive and specific biomarkers OATP that could used in conjunction with studies are currently demand. In present study, preclinical evaluations were conducted characterize suitability coproporphyrins (CPs) I III as markers hepatic functional...
Although the metabolism and disposition of diclofenac (DF) has been studied extensively, information regarding plasma levels its acyl-<i>β</i>-d-glucuronide (DF-AG), a major metabolite, in human subjects is limited. Therefore, DF-AG concentrations were determined (acidified blood derived) six healthy volunteers following single oral DF dose (50 mg). Levels high, as reflected by DF-AG/DF ratio 0.62 ± 0.21 (C<sub>max</sub> mean S.D.) 0.84 (area under concentration-time curve S.D.). Both also...
Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, MATE2K mediate the renal secretion of various cationic drugs can serve as loci drug-drug interactions (DDI). To support evaluation cynomolgus monkey a surrogate model for studying human organic transporters, genes were cloned shown to have high degree amino acid sequence identity versus their counterparts (93.7, 94.7, 95.4% OCT2, MATE1, MATE2K, respectively). Subsequently, three transporters individually...
Abstract Background Burkitt’s lymphoma, one of the most common subtypes pediatric malignant is notorious for its swift onset, aggressive proliferation, pronounced invasiveness, and marked malignancy. The therapeutic landscape lymphoma currently falls short providing universally effective tolerable solutions. Andrographolide, a primary active component Andrographis paniculata , renowned properties heat-clearing, detoxification, inflammation reduction, pain relief. It predominantly used in...
Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in antiangiogenesis which has been an essential strategy for cancer treatment. We report the first-in-human study of AK109, novel anti-VEGFR2 monoclonal antibody, to characterize safety profile and pharmacokinetics/pharmacodynamics (PK/PD) properties, explore preliminary antitumor efficacy patients with solid tumors.This was multicenter, open-label, phase I study, including dose escalation expansion (NCT04547205)....