A5100408177- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Protease and Inhibitor Mechanisms
- Mycobacterium research and diagnosis
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Genomics and Phylogenetic Studies
- Nuts composition and effects
- Plant and Fungal Interactions Research
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Kruppel-like factors research
- Radar Systems and Signal Processing
- Angiogenesis and VEGF in Cancer
- Genetic Mapping and Diversity in Plants and Animals
- Liver physiology and pathology
- Sirtuins and Resveratrol in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory mediators and NSAID effects
Second Hospital of Hebei Medical University
2019-2025
Sun Yat-sen University
2013-2024
Huazhong University of Science and Technology
2005-2024
Tongji Hospital
2020-2024
National Clinical Research Center for Digestive Diseases
2024
Ministry of Education of the People's Republic of China
2024
Nanyang Institute of Technology
2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Dalian Medical University
2009-2023
China Medical University
2023
Abstract Tumor-associated macrophages (TAMs) are the most abundant inflammatory infiltrates in tumor microenvironment and contribute to lymph node (LN) metastasis. However, precise mechanisms of TAMs-induced LN metastasis remain largely unknown. Herein, we identify a long noncoding RNA, termed Lymph Node Metastasis Associated Transcript 1 ( LNMAT1 ), which is upregulated LN-positive bladder cancer associated with prognosis. Through gain loss function approaches, find that promotes...
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cells (BCSCs) express high levels of H19, and ectopic overexpression significantly promotes cell clonogenicity, migration mammosphere-forming ability. Conversely, silencing represses these BCSC properties. In concordance, knockdown markedly inhibits tumor growth suppresses tumorigenesis...
Abstract Purpose: Chemoresistance and tumor relapse are the leading cause of deaths in bladder cancer patients. Bladder stem cells (BCSCs) have been reported to contribute these pathologic properties. However, molecular mechanisms underlying their self-renewal chemoresistance remain largely unknown. In current study, a novel lncRNA termed Low expressed Cancer Stem (lnc-LBCS) has identified explored BCSCs. Experimental Design: Firstly, we establish BCSCs model explore BCSCs-associated lncRNAs...
Castration-resistant prostate cancer (CRPC) that occurs after the failure of androgen deprivation therapy is leading cause deaths in patients. Thus, there an obvious and urgent need to fully understand mechanism CRPC discover novel therapeutic targets. Long noncoding RNAs (lncRNAs) are crucial regulators many human cancers, yet their potential roles molecular mechanisms poorly understood. In this study, we discovered lncRNA HOXD-AS1 highly expressed cells correlated closely with Gleason...
The prognosis for bladder cancer patients with lymph node (LN) metastasis is dismal and only minimally improved by current treatment modalities. Elucidation of the molecular mechanisms that underlie LN may provide clinical therapeutic strategies LN-metastatic cancer. Here, we report a long noncoding RNA LINC00958, which have termed cancer-associated transcript 2 (BLACAT2), was markedly upregulated in correlated metastasis. Overexpression BLACAT2 promoted lymphangiogenesis lymphatic both...
MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated the role of miR-124 breast and clarified regulation flotillin-1 (FLOT1) by miR-124.The expression levels were examined cell lines patient specimens using quantitative reverse transcription-PCR. The clinicopathological significance resultant data was later analyzed. Next, explored function to determine its potential on growth migration vitro. A luciferase reporter assay...
Purpose Worldwide, about 40% of women will experience pelvic organ prolapse (POP), and this proportion is expected to increase with the aging population. We investigated global, regional national influenza burden in past 30 years through age sociodemographic index (SDI). Patients methods Data were extracted from Global Burden Disease (GBD) 2019 database for 195 countries territories between 1990 2019. Estimated annual percentage changes (EAPCs) used explore age-standardized incidence rate...
Human osteosarcoma usually presented a high tendency to metastatic spread and caused poor outcomes, however, the underlying mechanism was still largely unknown. In present study, using series of in vitro experiments an animal model, we investigated roles HOX antisense intergenic RNA (HOTAIR) during proliferation invasion osteosarcoma. According with our results, HOTAIR commonly overexpressed osteosarcoma, which significantly correlated advanced tumor stage, highly histological grade...
The acquisition of drug resistance has been considered as a main obstacle for cancer chemotherapy. Tumor protein 53 target gene 1 (TP53TG1), p53-induced lncRNA, plays vital role in the progression human cancers. However, little is known about detailed function and molecular mechanism TP53TG1 cisplatin NSCLC. qRT-PCR analysis was used to detect expression TP53TG1, miR-18a PTEN mRNA NSCLC tissues cells. Western blot performed determine level cleaved caspase-3. Cell viability IC50 value were...
// Yang Peng 1, * , Wen Dong 3, Tian-xin Lin Guang-zheng Zhong 1 Bei Liao 2 Bo Wang 3 Gu Li Huang Yun Xie Fu-ding Lu Xu Chen Wei-bin He Shao-xu Wu Jian Department of Urology, Sun Yat-sen Memorial Hospital, University, Guangzhou, People’s Republic China Medical Examination Center, Guangdong Provincial Key Laboratory Malignant Tumor Epigenetics and Gene Regulation, SunYat-Sen These authors have contributed equally to this work Corresponding to: Dong, e-mail: wendong1210@hotmail.com...
The role of long non-coding RNAs (lncRNAs) in colorectal cancer (CRC) progression has not fully been elucidated. This study was designed to report the identification a novel lncRNA, lnc-GNAT1-1, and its functional CRC progression. lncRNA expression profile microarray performed three paired primary liver metastatic tissues CRC, identified be potential lncRNA. Quantitative real-time PCR used detect tissues, cell lines, patients' plasma, fractionation evaluate subcellular location. lnc-GNAT1-1...
Accumulating evidence suggests that long noncoding RNAs (lncRNAs) play an important role in oncogenesis and tumor progression. However, our knowledge of lncRNAs thyroid cancer is still limited. To explore the crucial involved papillary (PTC), we acquired data differentially expressed between PTC tissues paired adjacent noncancerous through lncRNA microarray. In microarray data, observed a newly identified lncRNA, HIT000218960, was significantly upregulated associated with well-known...
Colorectal cancer (CRC) is one of the most prevalent malignancies in world. Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) involved development many cancers. However, its role and mechanism CRC progression still need further exploration.The expression levels lnc-NEAT1, microRNA-150-5p (miR-150-5p) cleavage polyadenylation specific factor 4 (CPSF4) were determined by quantitative real-time PCR (qRT-PCR). The sensitivity cells to 5-fluorouracil (5-Fu) was measured...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editor-in-chief. In investigating concerns image duplications initially raised PubPeer (https://pubpeer.com/publications/DE92F16DF4B19FB114CFC27F8C798C), evidence for duplication in identical or altered fashion Figures 2B, 2C, 2E, and 2F was identified. addition, an investigation conducted by Supervision Committee National Natural...
Osteosarcoma (OS) is a common primary malignant bone tumor among adolescences, and the emergence of multidrug resistance poses huge challenge for clinical treatment OS. LncRNA HOTAIR (HOX antisense intergenic RNA) has been reported to be associated with many malignancies, including However, underlying mechanisms involved in drug OS are obscure. Our study showed that was upregulated cisplatin (DDP)-resistant tissues cells. knockdown decreased DDP resistance, resistance–related gene...
Our previous studies showed that dysregulation of the long noncoding RNA (lncRNA) HOXA11-AS plays an important role in development glioma. However, molecular mechanism glioma remains largely unknown. In this study, we explore mechanisms underlying abnormal expression and biological function for identifying novel therapeutic targets The HOXA11-AS, relationship between prognosis patients were analyzed using databases samples. Transcriptomics, proteomics, RIP, ChIRP, luciferase, ChIP assays...
ABSTRACT This study investigates the role of RASD2 (Ras Homolog Enriched In Striatum) in thyroid carcinoma progression and its modulation by microRNA‐485‐5p. Differential expression patterns were initially identified through bioinformatic analysis public databases. Immunohistochemical staining quantitative reverse transcription PCR (qRT‐PCR) validated these findings clinical specimens cell lines. Functional characterization was performed loss‐of‐function studies, examining cellular...
Glioma is the deadliest disease in human central nerve system. Abnormal expression of long noncoding RNA (lncRNA) has been demontrated to be implicated various cancers. The oncogenic role lncRNA NCK1-AS1 validated cervical cancer, wheras its glioma remians obscure. Our research findings suggested that was upregulated tissues and cells. deficiency hindered cell proliferation enhanced apoptosis. Additionally, chemoresistance radioresistance cells were impaired by depletion. Moreover,...
Glioblastomas are the most common and malignant central nervous system (CNS) tumors that occupied a highly heterogeneous tumor microenvironment (TIME). Long noncoding RNAs (lncRNAs), whose expression can be modified by DNA methylation, emerging as critical regulators in immune system. However, knowledge about epigenetic changes lncRNAs their contribution to heterogeneity of glioma is still lacking.
Background Ectopic angiogenesis within the intima and media is considered to be a hallmark of advanced vulnerable atherosclerotic lesions. Some studies have shown that specific matrix metalloproteinases (MMPs) might play different roles in angiogenesis. Therefore, we investigated predominant effects MMPs intraplaque plaque instability rabbit model atherosclerosis. Methods Results New Zealand rabbits underwent balloon injury abdominal artery ingestion high-cholesterol (1%) diet establish an...
BACKROUND Long noncoding RNAs (lncRNAs) play pivotal roles in various kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanisms lncRNAs colorectal cancer (CRC) liver metastasis still remain largely unknown. This study aimed to report a novel lncRNA, lnc-HSD17B-11:1, its functional role CRC progression. MATERIALS AND METHODS Differentially expressed lnc-HSD17B11-1:1 was screened identified from lncRNA profile microarray. Quantitative...