A5100647043- Neuroblastoma Research and Treatments
- Genetic Associations and Epidemiology
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- HIV/AIDS Research and Interventions
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- TGF-β signaling in diseases
- Genetic Mapping and Diversity in Plants and Animals
- Signaling Pathways in Disease
- Genetic and phenotypic traits in livestock
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Computational Drug Discovery Methods
- Metabolism, Diabetes, and Cancer
- Viral-associated cancers and disorders
- Hepatitis C virus research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Nutritional Studies and Diet
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
University of North Carolina at Greensboro
2021-2025
Second Hospital of Hebei Medical University
2014-2025
Children's Hospital of Los Angeles
2003-2024
Zhengzhou City Hospital
2023
Hebei Medical University
2014-2022
Qingdao Municipal Center for Disease Control and Prevention
2011-2022
Gansu Provincial Maternal and Child Health Hospital
2018-2022
Jewish General Hospital
2015-2019
Songjiang District Central Hospital
2019
McGill University
2014-2018
The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high 80×) nearly 10,000 individuals population-based disease collections. In extensively phenotyped cohorts characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel identify alleles associated with levels triglycerides (APOB), adiponectin (ADIPOQ) low-density...
Abstract For rare‐variant association analysis, due to extreme low frequencies of these variants, it is necessary aggregate them by a prior set (e.g., genes and pathways) in order achieve adequate power. In this paper, we consider hierarchical models relate rare variants phenotype modeling the effects as function variant characteristics while allowing for variant‐specific effect (heterogeneity). We derive two score statistics, testing group heterogeneity effect. make novel modification...
Previous studies have suggested that the sodium alginate (SA) is beneficial for treatment of non-alcoholic fatty liver disease (NAFLD), while potential mechanisms are largely unknown. The present study aimed to clarify effects and SA in preventing NAFLD via gut−liver axis. Thirty-two male Sprague−Dawley rats were randomly divided into four groups: normal control group (NC); high-fat diet (HFD); HFD with 50 mg/kg/d (LSA); 150 (HSA). After 16 weeks, scarified collect blood tissues. results...
The present study was undertaken to investigate the underlying mechanisms of long noncoding RNA OIP5-AS1 via regulating miR-410 modulate Wnt-7b in progression glioma. To address this problem, we measured expression and glioma tissues by qRT-PCR. Glioma U87 cells were transfected with siRNA or inhibitors. targeting relationships among miR-410, verified luciferase reporter assays. Western blotting employed determine Wnt-7b/β-catenin pathway-related proteins, while MTT, flow cytometry,...
Purpose: Functional loss of BRCA1 is associated with poorly differentiated and metastatic breast cancers that are enriched cancer stem cells (CSCs). CSCs can be generated from carcinoma through an epithelial-mesenchymal transition (EMT) program. We others have previously demonstrated suppresses EMT regulates the expression multiple EMT-related transcription factors. However, downstream mediators function in suppression remain elusive. Methods: Depletion or GATA3 activates p18INK4C , a cell...
Bone morphogenetic protein 4 (BMP4) is a potent growth factor that involved in many important biological processes. Regulation of the level secreted mature BMP4 determines effects on cells local microenvironment. Previous studies suggested Gremlin, member DAN family proteins, antagonizes activity by sequestering extracellular BMP4. Herein, we report novel intracellular regulatory mechanism which Gremlin interacts with precursor, prevents secretion BMP4, and therefore inhibits more...
A near infrared fluorescent probe utilizing the salicylaldehyde benzoyl hydrazone group as Cu 2+ receptor was developed and used to selectively sensitively monitor in living systems.
ABSTRACT This paper introduces an extended model that harnesses the power of convolution operations to represent time‐varying treatment and carry‐over effects in a crossover study design. Unlike traditional model, proposed approach unifies through response functions, one for each treatment. The is not only flexible enough accommodate variety plans, including multiple administrations at different doses, but also allows inclusion more periods. advantages this are accentuated by its ability be...
ABSTRACT This study investigates the role of RASD2 (Ras Homolog Enriched In Striatum) in thyroid carcinoma progression and its modulation by microRNA‐485‐5p. Differential expression patterns were initially identified through bioinformatic analysis public databases. Immunohistochemical staining quantitative reverse transcription PCR (qRT‐PCR) validated these findings clinical specimens cell lines. Functional characterization was performed loss‐of‐function studies, examining cellular...
Early embryonic lung branching morphogenesis is regulated by many growth factor-mediated pathways. Bone morphogenetic protein 4 (BMP4) one of the morphogens that stimulate epithelial in mouse explant culture. To further understand molecular mechanisms BMP4-regulated development, we studied biological role Smad-ubiquitin regulatory factor 1 (Smurf1), an ubiquitin ligase specific for BMP receptor-regulated Smads, during development. The temporo-spatial expression pattern Smurf1 was first...
Abstract Emerging evidence suggests that activation of the Notch1 signaling pathway inducing epithelial to mesenchymal transition (EMT) mediated by Snail/Slug promotes invasion and metastasis breast cancer cells in vitro . However, implication Notch1‐Snail/Slug‐EMT axis patients remains unclear. A total 200 formalin‐fixed paraffin‐embedded samples invasive ductal carcinoma (IDC), 37 adjacent non‐neoplastic tissue (ANNT) from who had not been treated with neoadjuvant therapy were examined....
For region-based sequencing data, power to detect genetic associations can be improved through analysis of multiple related phenotypes. With this motivation, we propose a novel test association simultaneously between set rare variants, such as those obtained by in small genomic region, and continuous We allow arbitrary correlations among the phenotypes build on linear mixed model assuming effects variants follow multivariate normal distribution with zero mean specific covariance matrix...
This study aims to determine whether toll-like receptor 4 (TLR4)-mediated inflammation in rostral ventrolateral medulla (RVLM) causes sympathetic overactivity leading preeclampsia (PE) and if TLR4 inhibition with hydrogen sulfide (H2S) would reduce PE severity. Thirty patients 30 pregnant controls were involved. rats was induced through deoxycorticosterone acetate normal saline. NaHS (donor of H2S), lipopolysaccharide (LPS) (TLR4 agonist), TAK-242 inhibitor) injected lateral cerebral...
The human PPIL1 (peptidyl prolyl isomerase-like protein 1) is a specific component of 35 S U5 small nuclear ribonucleoprotein particle and 45 activated spliceosome. It recruited by SKIP, another essential spliceosome, into spliceosome just before the catalytic step 1. stably associates with which also exists in as matrix protein. We report here solution structure determined NMR spectroscopy. resembles other members cyclophilin family exhibits PPIase activity. To investigate its interaction...
Abstract Background HIV-1 CRF07_BC recombinant previously circulated mainly among the intravenous drug users (IDUs) in Xinjiang province of China and is currently spreading entire country. The aim this study to characterize genotypic phenotypic properties isolates comparison with those subtype B' (Thailand B) which prevalent former plasma donors (FPDs) China. Results Twelve variants were isolated from blood HIV-1-infected IDUs province, 20 obtained FPDs Anhui Shanxi provinces All viruses...
Accumulating evidence has demonstrated that thioredoxin interacting protein (TXNIP) is abnormally expressed in a variety of malignant tumors and functions as tumor suppressor. However, the association between TXNIP clear cell renal carcinoma (CCRCC) not yet been fully elucidated. The aim present study was to evaluate role CCRCC using Cancer Genome Atlas (TCGA) database. RNA sequencing data corresponding clinical were collected from TCGA patient clinicopathological characteristics analyzed...
This study examined the association between famine exposure in early life and risk of metabolic syndrome (MetS) adulthood during 1959–1961 Chinese Famine. Two cross-sectional surveys involving randomly selected adults aged 35–74 years Qingdao area were conducted. A total 9,588 individuals grouped into four birth cohorts unexposed (born January 1, 1962, December 31, 1975), fetal-exposed 1959, 1961), childhood-exposed 1949, 1958), adolescence/adult-exposed 1931, 1948). We assessed prevalence...
Lectins are a group of proteins that recognize carbohydrates covalently linked to and lipids on the cell surface within extracellular matrix have diverse physiological functions1-3 including growth regulation,4-6 adhesion,7, 8 pre-mRNA splicing,9, 10 migration,11, 12 apoptosis,13-15 immune responses,16 pathogen recognition.17 The galectins family animal lectins defined by their shared conserved carbohydrate recognition domain (CRD) about 130 amino acids affinity for β-galactoside sugars.18,...
Abstract Background HIV-1 subtype B’ isolates have been predominantly circulating in China. Their intra- and inter-subtype neutralization sensitivity to autologous heterologous plasmas has not well studied. Results Twelve clinical obtained from patients were tested for their the antibodies infected by CRF07_BC subtypes, respectively. We found that B’-infected could potently neutralize viruses of with mean ID50 titer (1/x) about 67, but they effective neutralizing 8. The CRF07_BC-infected...
Bone morphogenetic protein (BMP) 4 plays very important roles in regulating developmental processes of many organs, including lung. Smad1 is one the BMP receptor downstream signaling proteins that transduce BMP4 ligand from cell surface to nucleus. The dynamic expression patterns embryonic mouse lungs were examined using immunohistochemistry. was predominantly detected peripheral airway epithelial cells early lung tissue [embryonic day 12.5 (E12.5)], whereas mesenchymal increased during...
The objective of this study was to assess the patterns genotypic and phenotypic resistance in a population blood donor patients infected with HIV-1 subtype B' (Thai B', clade B) from central China, previously treated harboring NRTI NNRTI mutations, purpose designing effective therapeutic regimens. pol genes 65 were sequenced estimated for drug while viruses isolated used analyze phenotype based on TZM-bl cell line. All strains one or more mutations RTIs possessed high cross-resistance EFV...
Abstract Background In order to induce a potent and cross-reactive neutralizing antibody (nAb), an effective envelope immunogen is crucial for many viral vaccines, including the vaccine human immunodeficiency virus (HIV). The Chinese equine infectious anemia (EIAV) attenuated has controlled epidemic of this after its vaccination in over 70 million animals during last 3 decades China. Data from our past studies demonstrate that Env protein plays pivotal role protecting horses both homologous...
Glioblastoma multiforme (GBM) is a highly malignant cancer in the brain with median survival time of approximately one year. However, mechanisms underlying GBM development and occurrence are poorly understood. Recently, miRNAs were reported to play important roles GBM. We performed microRNA profiling by comparing human cell line T98G control HCN1A. MicroRNA assays, PCR Western blot analysis detect expressions microRNAs, mRNAs proteins target genes, respectively. Cell migration invasion...