A5054103434- Axon Guidance and Neuronal Signaling
- Developmental Biology and Gene Regulation
- Zebrafish Biomedical Research Applications
- Hippo pathway signaling and YAP/TAZ
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Immunodeficiency and Autoimmune Disorders
- Cellular Mechanics and Interactions
- Angiogenesis and VEGF in Cancer
- Animal Genetics and Reproduction
- Wnt/β-catenin signaling in development and cancer
- Congenital gastrointestinal and neural anomalies
- Muscle Physiology and Disorders
- CRISPR and Genetic Engineering
- Cancer survivorship and care
- Antibiotics Pharmacokinetics and Efficacy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hair Growth and Disorders
- Protein Tyrosine Phosphatases
- Cell Adhesion Molecules Research
- Music Therapy and Health
- 3D Printing in Biomedical Research
- Cancer-related cognitive impairment studies
- Stroke Rehabilitation and Recovery
- Antibiotic Resistance in Bacteria
Union Hospital
2020-2025
Huazhong University of Science and Technology
2020-2025
China International Science and Technology Cooperation
2019-2024
Chongqing Medical University
2019-2024
Children's Hospital of Chongqing Medical University
2019-2024
Shandong University of Traditional Chinese Medicine
2023-2024
Wuhan Union Hospital
2021-2024
Union Hospital
2024
West Anhui University
2022-2023
The Francis Crick Institute
2000-2022
Pax6 and Pax2 are members of the Pax family transcription factors that both expressed in developing visual system zebrafish embryos. protein is present all cells form neural retina pigment epithelium, whereas located primarily will give rise to optic stalk. In this study, we have addressed role midline signalling regulation distributions subsequent morphogenesis eyes. Midline severely perturbed cyclops mutant embryos resulting an absence ventral CNS tissue fusion Mutant ectopically express a...
During development of the vertebrate hindbrain regulatory gene expression is confined to precise segmental domains. Studies cell lineage and suggest that establishment these domains may involve a dynamic regulation identity restriction movement between segments. We have taken dominant negative approach interfere with function Sek-1, member Eph-related receptor tyrosine kinase family expressed in rhombomeres r3 r5. In Xenopus zebrafish embryos expressing truncated lacking sequences, r3/r5...
ABSTRACT We describe the isolation and early developmental expression of three novel zebrafish genes (rtk1-3) that encode members eph family receptor tyrosine kinases. At onset gastrulation, rtk1 is expressed in shield region corresponding to future dorsal side embryo. As gastrulation proceeds, both rtk2 are within axial hypoblast along entire axis After gastrula stage complete, maintained precursor cells notochord tail bud but downregulated other regions hypoblast. rtk3 anterior including...
Eph receptor and ephrin signalling has a major role in cell segregation border formation, may act through regulation of adhesion, repulsion or tension. To elucidate roles we combined experiments culture assays with quantitations behaviour which are used computer simulations. Cells expressing EphB2, kinase-inactive EphB2 (kiEphB2), segregate form sharp ephrinB1-expressing cells, this is disrupted by knockdown N-cadherin. Measurements contact inhibition locomotion reveal that EphB2-, kiEphB2-...
The presence and identity of neural progenitors in the enteric nervous system (ENS) vertebrates is a matter intense debate. Here, we demonstrate that non-neuronal ENS cell compartment teleosts shares molecular morphological characteristics with mammalian glia but cannot be identified by expression canonical glial markers. However, unlike their counterparts, which are generally quiescent do not undergo neuronal differentiation during homeostasis, show relatively high proportion zebrafish...
We have generated an inducible system to control the timing of transgene expression in zebrafish and chick. An estrogen receptor variant (ERT2) fused GAL4 transcriptional activator rapidly robustly activates transcription within 3 hours treatment with drug 4-hydroxy-tamoxifen (4-OHT) tissue culture transgenic zebrafish. a broadly expressed ERT2-GAL4 line using ubiquitin (ubi) enhancer. In addition, use conjunction tissue-specific enhancers enables both space time. This spatial restriction...
The patterning of tissues to form subdivisions with distinct and homogeneous regional identity is potentially disrupted by cell intermingling. Transplantation studies suggest that segmental in the hindbrain maintained switching cells intermingle into another segment. We show occurs during normal development mediated feedback between segment retinoic acid degrading enzymes, cyp26b1 cyp26c1. egr2, which specifies rhombomeres r3 r5, underlies lower expression level cyp26c1 r5 compared r2, r4,...
Abstract Background Post-transplantation diabetes mellitus (PTDM) is a common metabolic complication following heart transplantation, which not only leads to elevated microvascular morbidity, but also seriously affects graft function and recipient survival. However, the specific metabolites underlying mechanisms are yet fully understood. Methods A total of 106 adult transplant recipients (56 PTDM 50 non-PTDM) who followed for more than one year were enrolled in study. The untargeted...
Neuronal differentiation is regulated by proneural genes that promote neurogenesis and inhibitory mechanisms maintain progenitors. This raises the question of how up-regulation required to initiate occurs in presence such inhibition. We carried out loss gain gene function, an interaction screen for binding partners, biochemical analyses uncover regulation, developmental role, mechanism action a ubiquitination adaptor protein, Btbd6a (BTB domain containing 6a). find neurog1 up-regulates...
Glioma is the deadliest disease in human central nerve system. Abnormal expression of long noncoding RNA (lncRNA) has been demontrated to be implicated various cancers. The oncogenic role lncRNA NCK1-AS1 validated cervical cancer, wheras its glioma remians obscure. Our research findings suggested that was upregulated tissues and cells. deficiency hindered cell proliferation enhanced apoptosis. Additionally, chemoresistance radioresistance cells were impaired by depletion. Moreover,...