A5100370997- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Kawasaki Disease and Coronary Complications
- MicroRNA in disease regulation
- Coronary Artery Anomalies
- Esophageal Cancer Research and Treatment
- Cleft Lip and Palate Research
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Cardiovascular Issues in Pregnancy
- Bioinformatics and Genomic Networks
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Immune Response and Inflammation
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Ferroptosis and cancer prognosis
- Autoimmune and Inflammatory Disorders Research
- Protease and Inhibitor Mechanisms
- Autophagy in Disease and Therapy
- Enhanced Recovery After Surgery
- Chronic Obstructive Pulmonary Disease (COPD) Research
Harbin Medical University
2008-2025
Hainan Medical University
2020-2025
Hainan General Hospital
2022-2025
Third Affiliated Hospital of Harbin Medical University
2024-2025
Jackson Laboratory
2025
Qingdao University
2022-2024
Affiliated Hospital of Qingdao University
2024
China Medical University
2014-2024
Nanjing Medical University
2024
Union Hospital
2024
Ferroptosis is a regulated form of cell death driven by small molecules or conditions that induce lipid-based reactive oxygen species (ROS) accumulation. This iron-dependent morphologically and genetically distinct from apoptosis, necroptosis, autophagy. miRNAs are known to play crucial roles in diverse fundamental biological processes. However, date no study has reported miRNA-mediated regulation ferroptosis. Here we show miR-137 negatively regulates ferroptosis directly targeting glutamine...
The relationship between the triglyceride‒glucose (TyG) index and clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore correlation TyG 28-day all-cause mortality patients. A retrospective observational cohort was conducted, including 8955 from MIMIC IV 2.2 database. primary outcome mortality. Multivariate logistic regression analysis restricted cubic spline were used assess Subgroup analyses sensitivity performed further validate...
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis and limited treatment options. While the majority of PDAC cases harbor KRAS mutations, approximately 8%–10% are wild‐type (KRAS‐WT). These KRAS‐WT tumors often contain actionable mutations gene fusions, making them more suitable for precision therapies. Identifying these molecular alterations crucial improving outcomes in this subset patients. This retrospective study involved 34 patients PDAC....
Lnc-DC is a specific group of long non-coding (Lnc) RNAs in dendritic cells (DCs). Its function has been previously studied, and includes roles cell differentiation the progression some diseases. In this study, we observed critical role regulating differentiation, growth, apoptosis cells.We first isolated peripheral blood mononuclear to culture induce into DCs, which were then co-cultured with hepatitis B virus (HBV)-secreting HepG2.2.15 for detection changes Lnc-DC. The expression levels...
Abstract Background The specific function of long noncoding RNAs (lncRNAs) in systemic lupus erythematosus (SLE) and the mechanism their involvement related pathological changes remain to be elucidated, so, this study, we analyzed differences expression profiles lncRNAs mechanisms action SLE using full high-throughput sequencing, bioinformatics, etc. methods. Methods We used sequencing detect lncRNAs, miRNAs, mRNAs PBMCs from patients with at genome-wide level. Next, predicted target genes...
Abstract Background Neoadjuvant immunochemotherapy (NICT) plus esophagectomy has emerged as a promising treatment option for locally advanced esophageal squamous cell carcinoma (LA-ESCC). Pathologic complete response (pCR) is key indicator associated with great efficacy and overall survival (OS). However, there are insufficient indicators the reliable assessment of pCR. Methods 192 patients LA-ESCC treated NICT from December 2019 to October 2023 were recruited. According pCR status,...
Abstract Motivation: Complex diseases are generally thought to be under the influence of one or more mutated risk genes as well genetic and environmental factors. Many traditional methods have been developed identify susceptibility assuming a single-gene disease model (‘single-locus methods’). Pathway-based approaches, combined with methods, consider joint effects factor biologic network context. With accumulation high-throughput SNP datasets human pathways, it becomes feasible search for...
Glioblastomas are the most common and malignant central nervous system (CNS) tumors that occupied a highly heterogeneous tumor microenvironment (TIME). Long noncoding RNAs (lncRNAs), whose expression can be modified by DNA methylation, emerging as critical regulators in immune system. However, knowledge about epigenetic changes lncRNAs their contribution to heterogeneity of glioma is still lacking.
Background: Blast traumatic brain injury (bTBI) can result in depression-like behaviors the acute and chronic phases. SSRIs have been shown to significantly alleviate animal models of (TBI) by increasing serotonin (5-HT) brain-derived neurotrophic factor (BDNF) hippocampus. However, therapeutic effects on depression caused bTBI remain unclear. Objective: Therefore, this study was aimed at investigating models. Methods: We created a rat model mild TBI subjecting rats increased blast...
Abstract The rapid growth of multi-omics datasets and the wealth biological knowledge necessitates development effective methods for their integration. Such are essential building predictive models identifying drug targets based on a limited number samples. We propose framework called GNNRAI supervised integration data with priors represented as graphs. Our leverages graph neural networks (GNNs) to model correlation structures among features from high-dimensional ‘omics data, which reduces...
Abstract This study examined the association between 49 markers in Runt‐related transcription factor 2 ( RUNX2 ) gene and nonsyndromic cleft lip with/without palate (CL/P) among 326 Chinese case‐parent trios, while considering gene‐environment (GxE) interaction parent‐of‐origin effects. Five single‐nucleotide polymorphisms (SNPs) showed significant evidence of linkage with CL/P these results were replicated an independent European sample 825 trios. We also report compelling for environmental...
In previously published articles, we evaluated the toxicity of four organophosphate (OP) pesticides (dichlorvos, dimethoate, acephate, and phorate) to rats using metabonomic technology at their corresponding no observed adverse effect level (NOAEL). Results show that a single pesticide elicits toxic response. This study aimed determine whether chronic exposure mixture above (at NOAEL) can lead joint action in same technology. Pesticides were administered daily through drinking water for 24...
In low or middle income countries chronic diseases are rapidly becoming the main cause of disease burden. However, focus health policymakers has been on preventing death from cancer and heart disease, with very little attention to growing problem long-term needs for care (dependence). Numbers dependent older people set quadruple by 2050. The economic impact providing is likely be substantial. study uses mixed methods draws extends population-based surveys conducted 10/66 Dementia Research...
Abstract SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with variety of human cancers, including breast cancer, but mechanisms involved are largely unclear. In current study, we investigated interactions between AXIN2 in their co-regulation on Wnt/β-catenin signal pathway, using clinical specimens microarray expression data from GEO database, for roles cancer. We compared levels other co-expressed genes pathway found that SOX7, SOX17 SOX18 was all reduced...
Glioblastoma multiforme (GBM) is a refractory tumor with poor prognosis and requires more effective treatment regimens. It has been confirmed that long noncoding RNAs (lncRNAs) substantially regulate various human disease including GBM. However, the biological roles its underlying molecular mechanisms still need to be further investigated. In this study, function potential mechanism of lncHAS2-AS1 in GBM were explored. was discovered HAS2-AS1 elevated glioma tissues correlated patients...
Kawasaki disease (KD) is a pyretic ailment predominantly observed in children aged below 5 years. There currently dearth of precise markers for timely identification incomplete (IKD). It imperative to develop updated, comprehensive, and evidence-based guidelines effectively direct clinical practice.