A5100744863- Signaling Pathways in Disease
- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Orthodontics and Dentofacial Orthopedics
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Osteoarthritis Treatment and Mechanisms
- Temporomandibular Joint Disorders
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Studies
- dental development and anomalies
- Medical Research and Treatments
- Estrogen and related hormone effects
- Sarcoma Diagnosis and Treatment
- Cleft Lip and Palate Research
- Toxin Mechanisms and Immunotoxins
- Healthcare and Venom Research
- Traditional Chinese Medicine Analysis
- Cancer Immunotherapy and Biomarkers
- Craniofacial Disorders and Treatments
- Natural product bioactivities and synthesis
- Mesenchymal stem cell research
- Retinal Development and Disorders
- RNA Research and Splicing
Nanjing University
2016-2025
Janssen (Switzerland)
2025
Wuhan University
2011-2024
Sun Yat-sen University
2009-2024
Harbin Veterinary Research Institute
2013-2024
Chinese Academy of Agricultural Sciences
2013-2024
Soochow University
2024
Central South University
2005-2024
Guangxi Medical University
2015-2024
Xiamen University
2018-2024
Abstract The desmoplastic stroma in solid tumors presents a formidable challenge to immunotherapies that rely on endogenous or adoptively transferred T cells, however, the mechanisms are poorly understood. To define involved, here we treat established pancreatic with CAR cells directed fibroblast activation protein (FAP), an enzyme highly overexpressed subset of cancer-associated fibroblasts (CAFs). Depletion FAP + CAFs results loss structural integrity matrix. This renders these...
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic progressive inflammatory joint diseases that affect a large population worldwide. Intra-articular administration of various therapeutics is applied to alleviate pain, prevent further progression, promote cartilage regeneration bone remodeling in both OA RA. However, the effectiveness intra-articular injection with traditional drugs uncertain controversial due issues such as rapid drug clearance barrier afforded by dense structure...
The murine Six gene family, homologous to Drosophila sine oculis (so) which encodes a homeodomain transcription factor, is composed of six members (Six1-6). Among the members, only Six2 has been previously shown be expressed early in kidney development, but its function unknown. We have recently found that Six1 also kidney. In developing kidney, uninduced metanephric mesenchyme at E10.5 and induced around ureteric bud E11.5. At E17.5 P0, expression became restricted subpopulation collecting...
The homeobox Six genes, homologues to Drosophila sine oculis(so) gene, are expressed in multiple organs during mammalian development. However, their roles auditory system development have not been studied. We report that Six1 is required for mouse During inner ear development, expression was first detected the ventral region of otic pit and later restricted middle vesicle within which, respectively, vestibular epithelia form. By contrast, excluded from dorsal which semicircular canals also...
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No AccessJournal of UrologyInvestigative Urology1 Mar 2009MicroRNA-143 as a Tumor Suppressor for Bladder Canceris companion ofIntravesical Mycobacterial Cell Wall-DNA Complex in the Treatment Carcinoma In Situ After Standard Intravesical Therapy Has FailedA Double-Blind Randomized Crossover Study Oral Thalidomide Versus Placebo Androgen Dependent Prostate Cancer Treated With Intermittent Ablation Tianxin Lin, Wen Dong, Jian Huang, Qiuhui Pan, Xinlan Fan, Caixia Zhang, and Li Huang LinTianxin...
Human induced pluripotent stem cells (iPSCs) provide a valuable model for regenerative medicine and human disease research. To date, however, the reprogramming efficiency of adult is still low. Recent studies have revealed that cell cycle key parameter driving epigenetic to pluripotency. As well known, retroviruses such as Moloney murine leukemia virus (MoMLV) require division integrate into host genome replicate, whereas target primary are mixture several types with different rhythms....
Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major constituent in cigarette smoke, inhibits regenerative potentials human ligament-derived stem cells (PDLSC) through microRNA (miRNA) regulation. In this study, we hypothesized delayed smokers is caused by afflicted potential smoker PDLSC. We cultured PDLSC from teeth extracted non-smokers. PDLSC, found significantly reduced...
Progression to a castration resistance state is the main cause of deaths in prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays central role progression Castration Resistant Prostate Cancer (CRPC), therefore understanding mechanisms AR activation milieu low androgen critical discover novel approach treat CRPC.Firstly, we explore CRPC associated lncRNAs by transcriptome microarray. The expression and clinical features lnc-LBCS are analyzed three independent large-scale...
Central post-stroke pain (CPSP) is an intractable and disabling central neuropathic that severely affects patients' lives, well-being, socialization abilities. However, CPSP has been poorly studied mechanistically its treatment remains challenging. Here, we used a rat model of induced by thalamic hemorrhage to investigate underlying mechanisms the effect stellate ganglion block (SGB) on emotional comorbidities.Thalamic was produced injecting collagenase IV into ventral-posterolateral nucleus...
Abstract Malocclusion, identified by the World Health Organization (WHO) as one of three major oral diseases, profoundly impacts dental-maxillofacial functions, facial esthetics, and long-term development ~260 million children in China. Beyond its physical manifestations, malocclusion also significantly influences psycho-social well-being these children. Timely intervention can foster an environment conducive to substantially decrease incidence or reduce severity complexity permanent...
Fractionation of the extract Aspergillus niger. IFB-E003, an endophyte in Cyndon dactylon, gave four known compounds naphtho-gamma-pyrones rubrofusarin B, fonsecinone A, asperpyrone B and aurasperone which were further investigated biologically. Rubrofusarin was shown to be cytotoxic colon cancer cell line SW1116 (IC50: 4.5 microgml-1), A inhibitory on XO (xanthine oxidase) 10.9 micromoll-1). Moreover, exhibited growth inhibitions against five test microbes with MICs ranging between 1.9 31.2...
A series of visible-light-driven mesoporous structured MnO(2)/TiO(2) nanocrystal photocatalysts have been synthesized through a modified sol-gel method, and the N(2) adsorption-desorption isotherm confirms that materials possess large pore size (up to 9.2 nm) narrow distribution. X-ray powder diffraction (XRD) analyses complementary x-ray photoelectron spectroscopy (XPS) measurements reveal doping transition metal Mn inhibits growth TiO(2) anatase nanocrystals species are highly dispersed on...
A novel Zn2+-sensitive fluorescent chemosensor SC/SBA-15 has been obtained by the self-assembly of 4-chloroaniline-N-salicylidene (SC), a Schiff base ligand, within channel silylation-modified SBA-15 without destroying its hexagonally ordered mesoporous structure. The remarkable 200-fold fluorescence enhancement with large Stokes shift 180 nm in luminescence emission upon addition Zn2+ is attributed to formation coordinate complex rigid conjugate system and ions.
BackgroundResistance to chemotherapeutic treatment is a common phenomenon in cancers, especially hepatocellular carcinoma (HCC). The Hippo signaling pathway has been demonstrated play role tumor initiation, development, and progression. However, little known about its roles the HCC chemoresistance.MethodsIn this study, real-time PCR western blotting were used identify expression profile of key components between chemoresistant chemosensitive cell lines. In vitro vivo loss- gain-of-function...
Rationale: Mesenchymal stem cells (MSCs) have been demonstrated to ameliorate inflammatory bowel disease by their actions on multiple immune cells, especially regulatory B (Breg cells). However, the phenotypes and functions of human MSCs (hMSCs)-treated Breg cell subsets are not yet clear. Methods: Purified were cocultured with immunomodulatory analyzed FACS proliferation assays in vitro. Also, a trinitrobenzenesulfonic acid-induced mouse colitis model was employed detect function...
Abstract: Extracellular vesicles (EVs) can deliver various bioactive molecules among cells, making them promising diagnostic and therapeutic alternatives in diseases. Mesenchymal stem cell-derived EVs (MSC-EVs) have shown potential similar to MSCs but with drawbacks such as lower yield, reduced biological activities, off-target effects, shorter half-lives. Improving strategies utilizing biotechniques pretreat enhance the properties of released EVs, well modifying MSC-EVs targeting abilities...