A5101523660- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Cervical Cancer and HPV Research
- Gastrointestinal motility and disorders
- Barrier Structure and Function Studies
- Retinal and Optic Conditions
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Anodic Oxide Films and Nanostructures
- Skin Protection and Aging
- Peanut Plant Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Retinal Development and Disorders
- Heat shock proteins research
- Neurological Disease Mechanisms and Treatments
- Protein purification and stability
- Corneal Surgery and Treatments
- Extracellular vesicles in disease
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
Ta Solutions (China)
2024-2025
Ningxia Medical University
2025
Henan Agricultural University
2021-2024
Henan Academy of Agricultural Sciences
2024
Sun Yat-sen University
2016-2024
Sun Yat-sen University Cancer Center
2020-2024
Beijing Children’s Hospital
2023
Capital Medical University
2023
Wannan Medical College
2021-2022
Children's Hospital of Fudan University
2022
Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major constituent in cigarette smoke, inhibits regenerative potentials human ligament-derived stem cells (PDLSC) through microRNA (miRNA) regulation. In this study, we hypothesized delayed smokers is caused by afflicted potential smoker PDLSC. We cultured PDLSC from teeth extracted non-smokers. PDLSC, found significantly reduced...
Abstract Retinal diseases are the leading causes of irreversible visual impairment and blindness in developed countries. Human retina has limited regenerative power to replace cell loss. Stem replacement therapy been proposed as a viable option. Previously, we have induced human adult periodontal ligament stem cells (PDLSCs) retinal lineage. In this study, modified our induction protocol direct PDLSCs into ganglion-like determined microRNA (miRNA) signature transdifferentiation process. The...
BAT1806/BIIB800 (Tofidence™/tocilizumab-bavi), a biosimilar of tocilizumab, demonstrated high degree analytical and functional similarity to reference tocilizumab (TCZ) in comprehensive comparative assessment. Minor differences with respect TCZ were observed for some attributes this study assessed the potential impact these through structure activity relationship characterization. Structure studies conducted assess glycation, glycosylation, charge variants, hydrophobicity, oxidation,...
Emerging evidence suggests that long non-coding RNAs (lncRNA) play critical roles in the development and progression of diverse cancers including hepatocellular carcinoma (HCC), but underlying molecular mechanisms lncRNAs are involved hepatocarcinogenesis have not been fully explored. Methods: In this study, we profiled lncRNA expression 127 pairs HCC nontumor liver tissues (a Discovery Cohort) using a custom microarray. The clinical significance lncCSMD1-1 were then validated with qRT-PCR...
Exosomal microRNAs (miRNAs) are potential biomarkers for a variety of tumors, but have not yet been studied in diffuse large B-cell lymphoma (DLBCL). Here, we investigated the use exosomal miRNAs DLBCL diagnosis and prognosis. A total 256 individuals, including 133 patients, 94 healthy controls (HCs), 29 non-DLBCL concurrent (CCs), were enrolled. profiled screening stage using microarray analysis, miRNA candidates confirmed training, testing, external testing stages qRT-PCR. Follow-up...
Purpose: We evaluate the effect of choroidal vessel density on residual length ellipsoid zone (EZ) and visual function in patients with retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). Methods: Fifty-three RP (n = 101 eyes) 53 normal participants 76 were enrolled this study. Patients assigned to three groups according their best-corrected acuity (BCVA). All underwent ophthalmologic examinations, including BCVA, fundus examination performed a slit-lamp an...
MicroRNAs (miRNAs) are upstream regulators of gene expression and involved in several biological processes. The purpose the present study was to obtain a detailed spatiotemporal miRNA profile mouse retina, identify one or more miRNAs that key retinal development investigate roles mechanisms these miRNAs. pattern developing retina acquired from Locked Nucleic Acid microarrays. Data were processed differentially expressed (DE‑miRNAs) using linear model Python 3.6. Following bioinformatics...
This study aimed to investigate the characteristics of female high‐risk human papillomavirus (HR‐HPV) infection in Shaanxi province China. A total 14 111 women were enrolled for HPV genotyping test, and a cytology, and/or cervix biopsy performed partial women. Of these women, rate was 30.21%, 26.73% caused by HR‐HPV. The most common HR‐HPV genotypes HPV‐16, HPV‐58, HPV‐52, HPV‐18, HPV‐31. prevalence among older than 50 years significantly higher other groups ( P < 0.05). main carcinogenic...
Tocilizumab is an immunoglobulin G1 monoclonal antibody targeting the interleukin-6 receptor (IL-6R). BAT1806/BIIB800 (tocilizumab-bavi) has been developed as a biosimilar to reference product tocilizumab (TCZ). The objective of this study was demonstrate physicochemical and functional similarity between TCZ in comprehensive comparability exercise.
Background: Accumulating evidence suggests that the polymerase I and transcript release factor (PTRF), a key component of caveolae structure on plasma membrane, plays pivotal role in suppressing progression colorectal cancers. However, PTRF development functional gastrointestinal (GI) disorders remains unclear. Post-infectious irritable bowel syndrome (PI-IBS) is common GI disorder occurs after an acute infection. Here, we focused occurrence PI-IBS investigated underlying mechanisms....
Postinfectious irritable bowel syndrome (PI-IBS) is a highly prevalent gastrointestinal disorder associated with immune dysregulation and depression- anxiety-like behaviors. Through traditional medicine, the active ingredient of Paeoniae Radix called paeoniflorin (PF) was previously found to prevent symptoms PI-IBS. However, there limited information on effects PF intestinal function in PI-IBS animal models. Here, we aimed determine treatment rat model. The model established via early...
Background: Triptolide (TP), a naturally derived compound from Tripterygium wilfordii , has been proven effective in protecting against cardiovascular system, but the molecular mechanisms underlying its protective effects are poorly understood. In current study, we sought to test potential role of TP regulation vascular calcification rat model and explore whether attenuates medial by upregulating miRNA-204. Methods: Vitamin D3 plus nicotine (VDN) was used induce (VC) aorta. Von Kossa...
BACKGROUND Owing to the increased incidence of photodermatosis caused by ultraviolet light in recent years, it is necessary clarify mechanisms potential photodamage skin and reveal possible therapeutic targets. Heat shock protein 27 (Hsp27) well known for suppressing apoptosis. The aim present study was elucidate photoprotective mechanism between Hsp27 p21 on B (UVB)-induced photodamage. MATERIAL AND METHODS gene interfered assess expression its downstream effectors, cell apoptosis,...
Plant protein–protein interaction (PPI) networks provide valuable information for the understanding of plant biological processes. In this study, we summarized and constructed nuclear-protein interactome Arabidopsis based on PPIs, preliminarily analyzed relationships among main pathways involving these protein interactions. These proteins are involved mainly in hormone signal transduction plant-pathogen interaction, linked closely by co-pathway nodal proteins. The key play important roles...
Introduction For childhood strabismus, early surgical intervention improves both motor and sensory outcomes. Botulinum toxin type A (BTX-A) injection is an alternative to incisional surgery that fast, less invasive, preserves a more normal biomechanical construct. This study was undertaken assess the safety effectiveness of BTX-A for horizontal concomitant strabismus in children our institution.Patients Methods Records all than age 18 years with follow-up at least 12 months who were treated...
The choroid plexus (CP) is a gateway for the exchange of various metabolites between microvasculature and brain. Impairment CP has been reported in diseases. Recently, dynamic-susceptibility-contrast-in-the-CSF (cDSC) MRI was developed to measure Gd-induced signal changes CSF. Here, cDSC performed with Intraperitoneal Gd-injection tauopathy mouse model examine permeability. maximal change greater ventricles tau mice than WT mice, indicating an increase Gd leakage from into through CP.