A5101595557- Computational Drug Discovery Methods
- RNA modifications and cancer
- Advanced Decision-Making Techniques
- Pharmacological Effects of Natural Compounds
- Regulation of Appetite and Obesity
- Genomics, phytochemicals, and oxidative stress
- Hearing, Cochlea, Tinnitus, Genetics
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Cancer Research and Treatments
- Synthesis and biological activity
- Protein Hydrolysis and Bioactive Peptides
- Ginkgo biloba and Cashew Applications
- Cancer-related molecular mechanisms research
- Enzyme Production and Characterization
- Cancer therapeutics and mechanisms
- Gastrointestinal motility and disorders
- Advanced Computational Techniques and Applications
- Nanocluster Synthesis and Applications
- Microbial Inactivation Methods
- Invertebrate Immune Response Mechanisms
- Digital and Cyber Forensics
- Energy Harvesting in Wireless Networks
- Cardiac tumors and thrombi
- Educational Environments and Student Outcomes
Wannan Medical College
2012-2025
Tongji University
2025
Shanghai Skin Disease Hospital
2025
Guangzhou Medical University
2021-2024
Xinyang College of Agriculture and Forestry
2024
State Key Laboratory of Respiratory Disease
2024
China Electric Power Research Institute
2023
North China Electric Power University
2023
Chinese Academy of Fishery Sciences
2021
Shanghai Ocean University
2021
ABSTRACT The main protease (Mpro) of SARS‐CoV‐2 is an attractive drug target for antivirals, as this enzyme plays a key role in virus replication. Drug repurposing promising option the treatment coronavirus disease 2019 (COVID‐19). Recently, number FDA‐approved drugs have been identified Mpro inhibitors, but stringent hit validation lacking. In study, we rigorously reevaluated vitro inhibition by repurposed via combined experiments, including fluorescence resonance energy transfer (FRET)...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible and has caused a pandemic named disease 2019 (COVID-19), which quickly spread worldwide. Although several therapeutic agents have been evaluated or approved for the treatment of COVID-19 patients, efficacious antiviral are still lacking. An attractive target SARS-CoV-2 main protease (Mpro), as this conserved enzyme plays key role in viral polyprotein processing genomic RNA replication. Therefore,...
Primary subcutaneous mycoses are a heterogeneous group of fungal infections caused by pathogenic or opportunistic organisms. In recent years, cases have steadily increased in Shanghai, an area where the disease was previously uncommon. This study aimed to summarize clinical experiences with primary optimize their management. A retrospective analysis conducted at Shanghai Dermatology Hospital from January 2018 March 2023 and enrolled 33 patients confirmed mycoses. Their medical histories,...
Recently, geraniin has been identified as a potent antiviral agent targeting SARS-CoV-2 main protease (Mpro). Considering the potential of in COVID-19 treatment, stringent validation for its Mpro inhibition is necessary. Herein, we rigorously evaluated
Modulation of drug metabolizing enzymes, leading to facilitated elimination carcinogens represents a successful strategy for cancer chemoprevention. Nitric oxide-donating aspirin (NO-ASA) is promising agent the prevention colon and other cancers. We studied effect NO-ASA on enzymes in HT-29 human adenocarcinoma Hepa 1c1c7 mouse liver cells Min mice treated with 3 weeks. In these cell lines, induced activity expression NAD(P)H:quinone oxireductase (NQO) glutathione S -transferase (GST)....
Acute lymphoblastic leukemia (ALL) is the most common form of pediatric cancer. METTL14, an N6-methyladenosine (m6A) modification protein, plays several roles in cancer development and involved pathogenesis various types cancers. However, role METTL14 gene single nucleotide polymorphisms (SNPs) ALL susceptibility remains to be investigated.A case-control design multinomial logistic regression were used develop models estimate overall risk for three SNPs (rs298982 G/A, rs298981 A/G rs1064034...
Platinum-based drugs are used to treat a variety of cancers but have many side effects such as nephrotoxicity and neurotoxicity. A folate-decorated nanoparticles system with good drug payload can selectively deliver into folate receptor (FR)-overexpressing cancer cells prevent the shortcomings platinum-based chemotherapy. Here, near-infrared (NIR) laser-activated (abbreviated PtIV-FINPs) were prepared via ultrasonic self-assembling platinum(IV) prodrug c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2,...
Brahma-related gene 1 (BRG1) has been implicated in the repair of DNA double-strand breaks (DSBs). Downregulation BRG1 impairs DSBs leading to accumulation double-stranded (dsDNA). Currently, role diabetic cardiomyopathy (DCM) not clarified. In this study, we aimed explore function and molecular by which regulates DCM using mice cell models. We found that was downregulated cardiac tissues cardiomyocytes cultured with high glucose palmitic acid (HG/PA), accompanied dsDNA activation cyclic...
Purpose: Methyltransferase like 1 (METTL1) regulates epitranscriptomes via the m7G modification in mammalian mRNA and microRNA. Systemic lupus erythematosus (SLE) is caused by abnormal immune reactivity has diverse clinical manifestations. RNA methylation as a mechanism to regulate gene expression widely implicated regulation. However, role of response SLE not been extensively studied. Patients Methods: Expression METTL1 was identified public dataset GSE122459 validated an independent cohort...
Background: The Wnt/ß-catenin/T cell factor (TCF) signaling pathway is important in the development of nonmelanoma skin cancers (NMSCs). Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemopreventive agents consisting a traditional NSAID attached to an NO-releasing moiety through chemical spacer. Previously we showed that aromatic spacer enhanced potency particular NO-NSAID compared aliphatic Methods: We synthesized with (flurbiprofen benzyl nitrate, NBS-242),...
Postinfectious irritable bowel syndrome (PI-IBS) is a highly prevalent gastrointestinal disorder associated with immune dysregulation and depression- anxiety-like behaviors. Through traditional medicine, the active ingredient of Paeoniae Radix called paeoniflorin (PF) was previously found to prevent symptoms PI-IBS. However, there limited information on effects PF intestinal function in PI-IBS animal models. Here, we aimed determine treatment rat model. The model established via early...
Purpose In continuous wave EPR imaging, the acquisition of high‐quality images was previously limited by requisite long times each image projection that typically greater than 1 second. To accelerate process facilitating numbers projections and higher resolution, instrumentation developed to greatly magnetic field scan is used obtain projection. Methods A low‐inductance solenoidal coil for scanning along with a spherical solenoid air core magnet, scans were driven triangular symmetric waves,...
The conventional peptide substrates of SARS-CoV-2 main protease (Mpro) are frequently associated with high cost, unstable kinetics, and multistep synthesis. Hence, there is an urgent need to design affordable stable Mpro for pharmacological research. Herein, we designed a functional substrate based on dimerization-dependent red fluorescent protein (ddRFP) the evaluation inhibitors
Abstract JC polyomavirus (JCPyV) is a human that can establish lifelong persistent infection in the majority of adults. It typically asymptomatic immunocompetent individuals. However, there risk developing progressive multifocal leukoencephalopathy (PML) immunocompromised or immunosuppressed patients. Though JCPyV commonly resides kidney-urinary tract, its involvement urinary system diseases extremely rare. Here, we reported case 60-year-old male patient with coronavirus disease 2019...
Abstract Background and Aims Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. N6-methyladenosine (m6A) the most common mRNA modification involved in various immune processes leading to homeostasis disorders. However, role m6A dysregulated response SLE remains unknown. Here, we aim explore pattern expression m6A-related proteins SLE. Method Peripheral blood mononuclear cells (PBMCs) from healthy controls patients were collected compare profile by methylated RNA...