A5058006003- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Immunotherapy and Immune Responses
- Colorectal and Anal Carcinomas
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
- Patient-Provider Communication in Healthcare
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Childhood Cancer Survivors' Quality of Life
- Receptor Mechanisms and Signaling
Sichuan University
2016-2025
West China Hospital of Sichuan University
2014-2025
Southern Medical University
2008-2025
Nanfang Hospital
2008-2025
Southwest Medical University
2025
Guangzhou University of Chinese Medicine
2025
North Sichuan Medical University
2025
West China Second University Hospital of Sichuan University
2003-2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Abstract Covalent organic frameworks (COFs), known for their exceptional in situ encapsulation and precise release capabilities, are emerging as pioneering drug delivery systems. This study introduces a hypoxia‐responsive COF designed to encapsulate the chemotherapy gambogic acid (GA) situ. Bimetallic gold‐palladium islands were grown on UiO‐66‐NH 2 (UiO) form UiO@Au‐Pd (UAPi), which encapsulated with GA through membrane formation, resulting core‐shell structure (UAPiGC). Further...
Abstract BACKGROUND: Extranodal natural killer/T‐cell lymphoma (ENKTL), nasal‐type, is a distinct entity of lymphoid tissue. ENKTL sensitive to radiotherapy (RT), but the prognosis poorer than for other types early lymphoma. The treatment schedule controversial. METHODS: A phase 2 study was conducted “sandwich” protocols, with earlier RT after an initial 3 cycles LVP ( L ‐asparaginase, vincristine, and prednisone), followed by further “consolidation” cycles. Patients aged 18 years older who...
Abstract Objective : Cancer patients and their families differed in attitude toward truth telling. The objective is to investigate different attitudes of Chinese or whether how disclose diagnosis with stages cancer examine the difference between two groups. Methods A questionnaire was delivered 1023 participants. Results Three hundred eighty‐two 482 completed questionnaire. were more likely than believe that patient should be informed (early‐stage, 90.8 vs 69.9%, P <0.001; terminal stage,...
Chronic stress could induce cancer metastasis by constant activation of the sympathetic nervous system, while cellular mechanism remains obscure. The aim this research is to explore associated negative effect chronic stress. analysis transcriptome sequencing implied that STAT3 signaling pathway downregulated miR-337-3p might be a potential epithelial mesenchymal transition (EMT) cell and promote under We also verified biological process in further experiments. Downregulation downregulate...
Abstract Background Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients lung cancer; however, standard of care therapies for LC-BrMs still limited their efficacy. A deep understanding molecular mechanisms and tumor microenvironment will provide us new insights into developing novel therapeutics treating LC-BrMs. Methods Here, we performed integrated analyses genomic, transcriptomic, proteomic, metabolomic, single-cell RNA sequencing data...
Overcoming immune tolerance of the growth factors associated with tumor should be a useful approach to cancer therapy by active immunity. We used vascular endothelial factor (VEGF) as model antigen explore feasibility immunogene vaccine based on single xenogeneic homologous gene, targeting angiogenesis. To test this concept, we constructed plasmid DNA encoding Xenopus VEGF (XVEGF-p) and control vectors. found that XVEGF was effective at both protective therapeutic antitumor immunity in...
: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients solid tumors also are at risk for IA because they may develop neutropenia as result of chemotherapy and radiotherapy. However, studies rare. In this study, the factors clinical characteristics pulmonary infection death mediated by invasive (IPA) complications lung cancer were determined.: The authors conducted retrospective analysis notes from 45 who had IPA.: Among 1711 cancer,...
11503 Background: No standard therapy is available in China for soft tissue sarcoma (STS) patients progressed after first-line chemotherapy. Anlotinib has shown single-agent activity a phase II study presented orally at 2016 ASCO. This aimed confirming anlotinib’s efficacy and safety advanced STS failure of Methods: Patients aged 18 years older with angiogenesis inhibitor naive, histologically proven STS, intolerance or to anthracycline-based chemotherapy, least one measurable lesion...
Cationic nanocarriers are reported to induce cell necrosis, especially in the lungs upon systemic administration. The release of damage-associated molecular patterns, such as mitochondrial DNA from injured may result inflammatory toxicity nanocarrier, which has largely limited its clinical application. Partial blocking surface charge cationic might improve their safety. As hyaluronan (HA) is an anionic polysaccharide that widely used for specific binding CD44 cellular uptake efficiency...
Artificial intelligence (AI) plays a substantial role in many domains, including medical fields. However, we still lack evidence to support whether or not cancer patients will accept the clinical use of AI. This research aims assess attitudes Chinese toward artificial medicine (AIM), and analyze possible influencing factors.A questionnaire was delivered 527 participants. Targeted people were who informed their diagnosis.The effective response rate 76.3% (402/527). Most trusted AIMs both...
Abstract Purpose This study will focus on 4T1 cells, a murine mammary adenocarcinoma cell line, as the primary research subject. We aim to investigate inhibitory effects and mechanisms of propranolol epithelial–mesenchymal transition (EMT) in breast cancer aiming elucidate this phenomenon at miRNA level. Methods In study, EMT effect was observed through vitro animal experiments. For screening potential target miRNAs downstream genes, second-generation sequencing (SGS) bioinformatics analysis...
Abstract Background Little is understood about the association between psychosomatic symptoms and advanced cancer among older Chinese patients. Methods This secondary analysis was part of a multicenter cross-sectional study based on an electronic patient-reported outcome platform. Patients with were included August 2019 December 2020 in China. Participants (over 60 years) completed MD Anderson Symptom Inventory (MDASI) Hospital Anxiety Depression Scale (HADS) to measure symptom burden....
Abstract The “sandwich” protocol, was first proposed by us and comprised of l ‐asparaginase, vincristine, prednisone chemotherapy with radiotherapy, results in 2‐year overall survival progression‐free rates that surpass traditional therapies for patients newly diagnosed, stage IE ‐ IIE , nasal type, extranodal natural killer/T‐cell lymphoma. had been published cancer. These were followed up over a median period 67 months, which updates the prognostic factors analyses are presented. 5‐year...