A5100722036- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Respiratory viral infections research
- Child Nutrition and Feeding Issues
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Autism Spectrum Disorder Research
- Virus-based gene therapy research
- Renal Diseases and Glomerulopathies
- Data-Driven Disease Surveillance
- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Animal Virus Infections Studies
- Family and Disability Support Research
- Cytomegalovirus and herpesvirus research
- Pancreatic and Hepatic Oncology Research
- Bladder and Urothelial Cancer Treatments
- Genetics and Neurodevelopmental Disorders
- Neurological Disease Mechanisms and Treatments
- COVID-19 Impact on Reproduction
- Epigenetics and DNA Methylation
- Lipoproteins and Cardiovascular Health
- Angiogenesis and VEGF in Cancer
- Multiple Myeloma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
Sichuan University
2001-2025
West China Medical Center of Sichuan University
2021-2024
Sichuan Cancer Hospital
2024
China International Science and Technology Cooperation
2019-2023
Children's Hospital of Chongqing Medical University
2016-2023
Chongqing Medical University
2008-2023
State Key Laboratory of Biotherapy
2015-2022
National Clinical Research
2019-2020
West China Hospital of Sichuan University
2020
GTx (United States)
2020
Overcoming immune tolerance of the growth factors associated with tumor should be a useful approach to cancer therapy by active immunity. We used vascular endothelial factor (VEGF) as model antigen explore feasibility immunogene vaccine based on single xenogeneic homologous gene, targeting angiogenesis. To test this concept, we constructed plasmid DNA encoding Xenopus VEGF (XVEGF-p) and control vectors. found that XVEGF was effective at both protective therapeutic antitumor immunity in...
Pleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or ascites (MA) is frequent in patients with advanced solid tumors that originate from the lung, breast, gastrointestinal tract ovary. Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination serous cavities. However, effusions constitute an immune-suppressive environment potentially induces cell dysfunction. Here, we demonstrated anti-tumor cytotoxicity conventional...
Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate gut metabolomic profiles autistic children and analyze potential interaction between metabolites with symptoms neurodevelopment levels. We involved 120 60 neurotypical children. Autistic levels were assessed. Fecal samples analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed metabolic disturbances multiple vitamin amino acid metabolism...
Abstract Objective Diabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an aging suppressor that plays a critical role in protecting podocytes DKD, mainly expressed tubular epithelium and secreted blood. However, it has not been established whether Klotho can alleviate injury inhibiting renal ox-LDL deposition, potential molecular mechanisms require further investigation. Methods...
Background: Antibody-drug conjugates have recently been introduced as a treatment for advanced urothelial carcinoma. The EV-301 study demonstrated that enfortumab vedotin (EV) improved overall survival compared with conventional chemotherapy. To assess the cost-effectiveness of EV carcinoma (UC) from payer perspective in middle- and high-income countries. Methods: A decision analysis model was developed to efficacy economic viability subsequent-line following disease progression patients...
Few studies have demonstrated that the relationship between m6A-related genes and prognosis, tumor microenvironment drug resistance of LC.The main results were analyzed with bioinformatics methods.Hence, we found 10 expressed less in samples comparison normal ones. Using consensus clustering, all LC patients grouped into 2 subgroups according to overall expression differential genes. In two clusters, OS immune characteristics different. We predictive potential prognosis LC, obtained a risk...
Abstract Background Growing evidence has shown that atopic dermatitis (AD) may decrease lung cancer (LC) risk. However, the causality between two diseases is inconsistent and controversial. Therefore, we explored causal relationship AD different histological subtypes of LC by using Mendelian randomization (MR) method. Materials methods We conducted MR study based on summary statistics from genome‐wide association studies (GWAS) (10,788 cases 30,047 controls) (29,266 56,450 controls)....
Abstract Lessons Learned The upregulation of dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) are important mechanisms resistance to 5-fluorouracil (5-FU) in metastatic colorectal cancer (mCRC) after long exposure 5-FU. S-1 (containing a DPD inhibitor) combined with raltitrexed (a TS showed moderate effect, which needs further study as third- or later-line therapy mCRC. Background is fundamental drug the treatment (mCRC). Patients mCRC often exposed 5-FU and/or its...
The aim of this study was to investigate the effects simvastatin, a competitive inhibitor 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, on inflammation and glomerulosclerosis in Adriamycin (ADR)-induced nephropathy. Male Sprague-Dawley rats were randomly divided into control, ADR nephrosis, simvastatin-treated nephrosis groups. nephropathy induced by single-tail intravenous injection (6.5 mg/kg). Anti-inflammatory simvastatin studied evaluating expression inflammatory mediators...
Abstract Objective To investigate the impact of COVID-19 outbreak on medical advice seeking Chinese children with chronic kidney disease (CKD). Materials and Methods An anonymous online questionnaire survey was conducted in 17 pediatric nephropathy diagnosis treatment centers China. The questions collected basic information patients their parents data changes approach to needs context etc. This is a Multicenter Cross-section Study. Results A total 735 valid questionnaires were collected. 555...
The fragile-site associated tumor suppressor (FATS, formerly known as C10orf90), a regulator of p53-p21 pathway has been involved in the onset breast cancer. Recent data support idea that crosstalk between FATS and p53 may be physiological importance for reproduction during evolution. aim current study was to test hypothesis genetic polymorphism can influence risk We conducted population-based studies two independent cohorts comprising 1 532 cases 573 controls Tianjin North China, 804 835...
Background: The aim of this study is to evaluate the pharmacoeconomic profile adding enzalutamide first-line treatment for metastatic, hormone-sensitive prostate cancer (mHSPC) from US and Chinese payers' perspectives. Materials Methods: A Markov model with three health states: progression-free survival (PFS), progressive disease (PD), death, was constructed. All patients were assumed enter in PFS state transit according transition structure. Efficacy data derived ENZAMET trial Weibull...
Aims and Background To evaluate the adverse events (AEs) of bleeding caused by bevacizumab/5-fluorouracil/ leucovorin (5-FU/LV) combination chemotherapy with addition irinotecan or oxaliplatin in patients metastatic colorectal cancer (mCRC). Methods A retrospective study was conducted to AEs associated bevacizumab explore potential associations between baseline patient characteristics. The National Cancer Institute Common Terminology Criteria for Adverse Events v4.0 were used classify...