A5008599644- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Extracellular vesicles in disease
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Protein Tyrosine Phosphatases
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Anodic Oxide Films and Nanostructures
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Vitamin D Research Studies
- Galectins and Cancer Biology
- Neuroendocrine Tumor Research Advances
- Cell death mechanisms and regulation
- Radical Photochemical Reactions
- Vasculitis and related conditions
- Inflammasome and immune disorders
- ATP Synthase and ATPases Research
Jinan University
2020-2025
Zhuhai Institute of Advanced Technology
2024
Guangzhou University of Chinese Medicine
2023
Guangdong Provincial People's Hospital
2023
First Affiliated Hospital of Jinan University
2020-2022
Shantou University Medical College
2019
Shantou University
2019
Children's Hospital of Chongqing Medical University
2016
Chongqing Medical University
2016
Renji Hospital
2011-2012
In previous studies, lactate dehydrogenase A ( LDHA ) was identified as one of the leading genes that promote proliferative and tumorigenic potential malignancies. However, less definitive evidence reported in hepatocellular carcinoma HCC cells. Furthermore, role promoting metastasis , its possible mechanism, is not clear. this study, RNA interference i) mediated by lentiviral vectors (which induce strong down‐regulation gene expression) used to analyze tumor growth . We performed transient...
Abstract Background The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-dependent manner responses to variety of stresses that common cancers. We focus on cancer-enriched tsRNA signature develop salivary exosome-based non-invasive biomarker for human esophageal squamous cell carcinoma (ESCC). Methods Cancer-enriched were identified by RNA sequencing exosomes obtained from ESCC patients ( n = 3) and healthy controls pilot study further validated discovery cohort 66). A multicenter...
The tumor immune microenvironment (TIME) has an important impact on response to cancer immunotherapy using checkpoint inhibitors. Specifically, "infiltrated-excluded"/"cold" TIME is predictive of poor response. antidiabetic agent metformin may influence anticancer immunity in esophageal squamous cell carcinoma (ESCC).We analyzed matched pre- and posttreatment ESCC specimens a phase II clinical trial low-dose treatment (250 mg/day) evaluate direct anti-ESCC activity reprogramming. Follow-up...
Abstract Purpose: Transcriptionally induced chimeric RNAs are an important emerging area of research into molecular signatures for biomarker and therapeutic target development. Salivary exosomes represent a relatively unexplored, but convenient, noninvasive cancer discovery. However, the potential cancer-derived exosomal in saliva as biomarkers is unknown. Here, we explore clinical utility salivary GOLM1-NAA35 RNA (seG-NchiRNA) esophageal squamous cell carcinoma (ESCC). Experimental Design:...
A generalizable strategy for the synthesis of rare-earth metal–organic frameworks (RE-MOFs) with 12-connected RE 9 clusters and shp topology. Pyrazine functionalization to boost antenna effect, realizing a robust platform tetracyclines detection.
Early detection of esophageal squamous cell carcinoma (ESCC) will facilitate curative treatment. We aimed to establish a microRNA (miRNA) signature derived from salivary extracellular vesicles and particles (EVPs) for early ESCC prognostication.Salivary EVP miRNA expression was profiled in pilot cohort (n = 54) using microarray. Area under the receiver operator characteristic curve (AUROC) least absolute shrinkage selector operation regression analyses were used prioritize miRNAs that...
Periodontitis is the most prevalent inflammatory disease of periodontium, and related to oral systemic health. Exosomes are emerging as non-invasive biomarker for liquid biopsy. We here evaluated levels programmed death-ligand 1 (PD-L1) mRNA in salivary exosomes from patients with periodontitis non-periodontitis controls. The purposes this study were establish a procedure isolation detection saliva patients, characterize level exosomal PD-L1, illustrate its clinical relevance. Bioinformatics...
Abstract Cancer vaccines critically rely on the availability of targetable immunogenic cancer‐specific neoepitopes. However, mutation‐based neoantigens are rare or even non‐existent in subgroups cancer types. To address this issue, we exploited a aberrant transcription‐induced chimeric RNA, designated A‐P as chiRNA, possible source clinically relevant and neoantigens. chiRNA encodes recently discovered protein that comprises full‐length astrotactin‐2 ( ASTN2 ) C‐terminally fused in‐frame to...
Significance An explanation has been lacking for the suppressive action of antagonists growth hormone-releasing hormone receptors (GHRH-Rs) on cancers that do not express GHRH-Rs, an established target antagonists. We demonstrate here esophageal squamous cell carcinoma (ESCC), a representative cancer type barely expresses responds to GHRH-R Hypoxia induces splice variant 1 (SV1) and activates key glycolytic enzyme. Glycolytic metabolism tumor progression are promoted by activation SV1...
Smoking is one of the most impactful lifestyle-related risk factors in many cancer types including esophageal squamous cell carcinoma (ESCC). As major component tobacco and e-cigarettes, nicotine not only responsible for addiction to smoking but also a carcinogen. Here we report that enhances ESCC malignancy tumor-initiating capacity by interacting with cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) subsequently activating JAK2/STAT3 signaling pathway. We found aberrant CHRNA7...
Resistance to targeted therapy is one of the critical obstacles in cancer management. trastuzumab frequently develops treatment for HER2
Tumor-derived exosomes, containing multiple nucleic acids and proteins, have been implicated to participate in the interaction between tumor cells microenvironment. However, functional involvement of phosphatases tumor-derived exosomes is not fully understood. We others previously demonstrated that protein tyrosine phosphatase receptor type O (PTPRO) acts as a suppressor cancer types. In addition, its role immune microenvironment remains elusive. Bioinformatical analyses revealed PTPRO was...
Electron donor–acceptor complexes are commonly employed to facilitate photoinduced radical-mediated organic reactions. However, achieving these photochemical processes with catalytic amounts of donors or acceptors can be challenging, especially when aiming reduce catalyst loadings. Herein, we have unveiled a framework-based heterogenization approach that significantly enhances the photoredox activity perylene diimide species in radical addition reactions alkyl silicates by promoting faster...
Background CD73 is an ecto-enzyme that involved in the conversion of pro-inflammatory extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory adenosine (ADO). A broad variety solid types was shown exploit overexpression as a suppressive immune checkpoint. Consequently, CD73-antagonistic antibodies, most notably oleclumab, are currently evaluated several multicenter trials for clinical applicability. However, efficacy conventional monospecific CD73-inhibiting...
Transcription-induced chimeric RNAs are an emerging area of research into molecular signatures for disease biomarker and therapeutic target development. Despite their importance, little is known RNAs-relevant roles the underlying mechanisms cancer pathogenesis progression. Here we describe a unique ASTN2-PAPPAantisense RNA (A-PaschiRNA) that could be first reported derived from splicing exons intron antisense two neighboring genes, respectively. Aberrant A-PaschiRNA level in ESCC tissues was...
Abstract Background High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. purpose of this work is to explore the radiobiologic effect prolonged fraction time on tumor response and survival in vivo. Methods 1-cm-diameter Lewis lung cancer tumors growing legs C57BL mice were used. To evaluate prolongation, 18 Gy was...
OBJECTIVE: To investigate the effects of ezrin targeting gene RNA interference (RNAi) on human gastric cancer cell line SGC‐7901 in vitro . METHODS: The highly metastatic transfected with a small interfering (siRNA) lentivirus vector was selected for this research study. Expressions mRNA and protein cells were detected using RT‐PCR Western blot. Cell apoptosis observed flow cytometry. Transwell invasion adhesion test used to verify effect RNAi expression RESULTS: Ezrin via RNAi‐mediated had...
Primary esophageal small cell carcinoma (PESCC) is a weakly prevalent but lethal malignancy with early metastasis and poor prognosis. Currently, neither effective prognostic indicators nor curative therapies are available for PESCC. Immunotherapy has now evolved into one of the most promising cancer patients. Tumor-infiltrating immune cells which integral to tumor microenvironment (TIME) recognized as highly important prognosis prediction, while responsiveness checkpoint blockade may be...
Abstract Because of their misuse and poor management, antibiotics pose a significant threat to the ecological environment human health. The development highly sensitive effective sensors detect such environmental contaminants is crucial challenging task. As new class desirable biocompatible materials, biological metal‐organic frameworks are considered as viable platform for sensing applications. Herein, we report synthesis luminescent framework [Zn 6 Ad 4 (BPDC‐(OH) 2 ) ] n ( JNU‐104 using...
An amine-functionalized biological metal–organic framework serving as a crystalline model for mimicking formaldehyde-induced DNA–protein crosslinks in confined space.
Two isostructural pillar-layer MOFs (JNU-105 and JNU-105-(NH2)2) have been successfully synthesized. JNU-105-(NH2)2 exhibits a red-shifted luminescence "turn on" for formaldehyde without the interference from other VOCs detection limit of 1.87 ppb. In situ single-crystal transformation studies confirm aminal formation on pillar linker, which was attributed to exclusive response toward formaldehyde.