A5078215172- Bone Metabolism and Diseases
- Bone health and treatments
- Cytokine Signaling Pathways and Interactions
- Orthodontics and Dentofacial Orthopedics
- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- Mesenchymal stem cell research
- Bone health and osteoporosis research
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Temporomandibular Joint Disorders
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Cleft Lip and Palate Research
- Erythrocyte Function and Pathophysiology
- Endodontics and Root Canal Treatments
- Immune cells in cancer
- Bone and Dental Protein Studies
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
Shanghai Jiao Tong University
2015-2025
Shanghai Ninth People's Hospital
2016-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
National Clinical Research
2020-2024
Shanghai Stomatological Hospital
2023-2024
Shanghai Municipal Commission of Health and Family Planning
2015
Stem cell-independent reprogramming of differentiated cells has recently been identified as an important paradigm for repairing injured tissues. Following periportal injury, mature hepatocytes re-activate reprogramming/progenitor-related genes (RRGs) and dedifferentiate into liver progenitor-like (LPLCs) in both mice humans, which contribute remarkably to regeneration. However, it remains unknown how external factors trigger hepatocyte reprogramming. Here, by employing single-cell...
Aging skin, vulnerable to age-related defects, is poor in wound repair. Metabolic regulation accumulated senescent cells (SnCs) with aging essential for tissue homeostasis, and adequate ATP important cell activation aged Strategies metabolism intervention hold prospects therapeutic advances. Here, we found energy metabolic changes skin from patients mice. Our data show that metformin engineered EV (Met-EV) can enhance mouse repair, as well ameliorate cellular senescence restore dysfunctions....
The transcription factor signal transducer and activator of 3 (STAT3) plays a central role in cell survival function. STAT3 has been demonstrated to participate the maintenance bone homeostasis osteoblasts, but its osteoclasts vivo remains poorly defined. Here, we generated conditional knockout mouse model which Stat3 was deleted using cathepsin K-Cre (Ctsk-Cre) driver. We observed that osteoclast-specific deficiency caused increased mass mice, attributed impaired catabolism by osteoclasts....
Skeletal deformities are typical AD-HIES manifestations, which mainly caused by heterozygous and loss-of-function mutations in Signal transducer activator of transcription 3 (STAT3). However, the mechanism is still unclear treatment strategy limited. Herein, we reported that mice with Stat3 deletion osteoblasts, but not osteoclasts, induced AD-HIES-like skeletal defects, including craniofacial malformation, osteoporosis, spontaneous bone fracture. Mechanistic analyses revealed STAT3...
Abstract Malocclusion, identified by the World Health Organization (WHO) as one of three major oral diseases, profoundly impacts dental-maxillofacial functions, facial esthetics, and long-term development ~260 million children in China. Beyond its physical manifestations, malocclusion also significantly influences psycho-social well-being these children. Timely intervention can foster an environment conducive to substantially decrease incidence or reduce severity complexity permanent...
Abstract: The surface structure of bioceramic scaffolds is crucial for its bioactivity and osteoinductive ability, in recent years, human periodontal ligament stem cells have been certified to possess high osteogenic cementogenic differential ability. In the present study, hydroxyapatite (HA) bioceramics with micro-nano-hybrid (mnHA [the hybrid nanorods microrods]) were fabricated via hydrothermal reaction α-tricalcium phosphate granules as precursors aqueous solution, effects mnHA on...
Mammalian target of rapamycin complex 1 (mTORC1) is involved in anabolic metabolism both osteoblasts and chondrocytes, but the role mTORC1 osteoclast biology vivo remains to be elucidated. In this study, we showed that deletion regulatory-associated protein mTOR (Raptor) osteoclasts led an increase bone mass with decreased resorption. Raptor-deficient marrow-derived macrophages exhibited lower mTORC1-S6K1 signaling retarded differentiation, as determined by number osteoclasts,...
The mammalian target of rapamycin (mTOR)/regulatory-associated protein mTOR (Raptor) pathway transmits and integrates different signals including growth factors, nutrients, energy metabolism. Nearly all these have been found to play roles in skeletal biology. However, the contribution mTOR/Raptor osteoblast biology vivo remains be elucidated as conclusions recent studies are controversial. Here we report that mice with a deficiency either or Raptor preosteoblasts exhibited clavicular...
Abstract Objectives Alveolar bone osteoporosis has attracted more and attention because of its profound impact on stomatognathic function treatment, but current treatments have not been targeted to alveolar might even cause severe side effects. Thus, identifying the effects anti‐osteoporosis agents is essential. Icariin ameliorates metabolic dysfunction long bones, remain unclarified. Materials methods BMSCs were isolated from rat mandibles (mBMSCs). The osteogenic potential mBMSCs...
Introduction Maxillary transverse deficiency (MTD) is a common type of malocclusion. For adult MTD patients with highly ossified midpalatal sutures, surgically assisted rapid palatal expansion (SARPE) has been the conventional method maxillary expansion. However, SARPE disadvantages significant trauma, high cost and incidence adverse events. Therefore, we proposed novel minimally invasive for expansion, which suture osteotomy combined microimplant-assisted (MSO-MARPE). The results are...
Background: Osteoporosis is a world-wide health problem, which leads to decreased bone strength and increased susceptibility fractures. Puerarin, phytoestrogen extracted from Pueraria lobata (Willd.) Ohwi, has been identified as promising intervention for preventing loss promoting regeneration. However, the underlying mechanisms its anabolic action are still not clear. In present study, we aimed investigate effect of puerarin on osteogenic differentiation marrow stromal cells (BMSCs)...
Abstract Overactivated inflammatory reactions hinder the bone regeneration process. Timely transformation of microenvironment from pro‐inflammatory to anti‐inflammatory after acute immune response is favorable for osteogenesis. Macrophages play an important role in inflammation. Therefore, this study adopts TIM3 high expression extracellular vesicles (EVs) with immunosuppressive function reshape early injury, mainly by targeting macrophages. These EVs can be phagocytosed macrophages, thereby...
Abstract Healthy alveolar bone is the cornerstone of oral function and treatment. Alveolar highly dynamic during entire lifespan affected by both systemic local factors. Importantly, subjected to unique occlusal force in daily life, mechanical a powerful trigger remodeling, but effect maintaining mass remains ambiguous. In this study, Piezo1 channel identified as an sensor. Activation rescues loss caused force. Moreover, we identify mediator osteoblasts, homeostasis directly promoting...
There is a growing body of evidence indicating an association between osteoporosis and vascular diseases, which are associated with reduced blood supply. Decreased flow results in hypoxic gradient the local microenvironment, affecting bone remodeling. Bone mesenchymal stem cells (BMSCs) have been demonstrated to be key To elucidate molecular mechanisms involved supply osteoporosis, present study investigated effect hypoxia on BMSCs vitro during osteogenesis. The BMSC osteogenesis process was...
The high prevalence of malocclusion and dentofacial malformations means that the demand for orthodontic treatments has been increasing rapidly. As biological basis treatment, mechanism mechanical force–induced alveolar bone remodeling during tooth movement (OTM) become key scientific issue orthodontics. It demonstrated mesenchymal stem cells (BMSCs) are crucial exhibit sensing properties. Mechanical force can promote osteoblastic differentiation BMSCs osteogenesis, but factor mediates...
Bone exhibits changes in density, strength, and microarchitecture relation to mechanical loading mediated by exercise. Appropriate exercise maintains bone homeostasis, while the absence of leads disuse loss. However, acting mechanism mechanotransduction remains unclear. We performed running-wheel tail suspension model study effects on metabolism, found that osteoblastic Signal transducer activator transcription 3 (STAT3) activity was closely related exercise-induced mass metabolism changes....
Mechanical stress plays a crucial role in bone formation and absorption. We investigated the osteoblastic differentiation of mesenchymal stem cells (BMSCs) affected by intermittent traction stretch at different time points explored mechanism under this special mechanical stimulation. The BMSCs C3H10T1/2 were subjected to 10% elongation for 1–7 days using Flexcell Strain Unit, then mRNA levels genes expression core-binding factor a1 (Cbfa1) examined. Furthermore, we focused specifically on...
The metabolism and remodeling of alveolar bone are the most active among whole skeletal system, which is related to biological characteristics heterogeneity mesenchymal stromal cells (MSCs). However, there a lack systematic description MSC-derived osteoblastic lineage as well their distinct osteogenic differentiation trajectory bone. In this study, we constructed single-cell atlas mouse through RNA sequencing (scRNA-seq). Remarkably, by comparing cell compositions between long bone,...
As the number of elderly orthodontic patients increases, impact postmenopausal osteoporosis on tooth movement (OTM) has attracted a great deal attention because OTM relies alveolar bone remodeling. The question whether causes subsequent loss and is harmful to health under osteoporotic conditions remains be answered. present study aimed clarify influences in rats. was accelerated ovariectomized (OVX) rats as result increased resorption pressure area. At same time, anabolic formation promoted...