A5101818803- Clinical Nutrition and Gastroenterology
- Facial Trauma and Fracture Management
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ and Tissue Transplantation Research
- Bone Metabolism and Diseases
- Cleft Lip and Palate Research
- Glioma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Dental Radiography and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Spinal Fractures and Fixation Techniques
- Advanced Glycation End Products research
- Reconstructive Surgery and Microvascular Techniques
- Cancer, Hypoxia, and Metabolism
- Diverticular Disease and Complications
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
- Caveolin-1 and cellular processes
- Obstructive Sleep Apnea Research
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Craniofacial Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Magnolia and Illicium research
Shanghai Ninth People's Hospital
2016-2024
Nanjing Medical University
2011-2024
Jiangsu Province Hospital
2024
Huadong Hospital
2017-2024
Fudan University
2017-2024
National Clinical Research
2023
Shanghai Jiao Tong University
2009-2023
Shanghai Changzheng Hospital
2023
Wuxi People's Hospital
2011-2021
National Clinical Research Center for Digestive Diseases
2021
Patients with liver cancer who received HIFU ablation were included in this analysis, including PLC cohort (n=80) and MLC (n=195). The primary endpoint of our research was tumor response. secondary endpoints survival outcomes (OS), VAS pain scores, AFP reliefs, complications. ORR DCR observed to be 71.8% 81.2%, respectively patients HCC, 63.7% 83.2% cases MLC. levels significantly decreased after treatment comparing the baseline HCC (p<0.05). Median overall estimated 13.0 12.0 months cohort....
Abstract Healthy alveolar bone is the cornerstone of oral function and treatment. Alveolar highly dynamic during entire lifespan affected by both systemic local factors. Importantly, subjected to unique occlusal force in daily life, mechanical a powerful trigger remodeling, but effect maintaining mass remains ambiguous. In this study, Piezo1 channel identified as an sensor. Activation rescues loss caused force. Moreover, we identify mediator osteoblasts, homeostasis directly promoting...
Pancreatic cancer remains one of the most lethal types cancer. Late‑stage pancreatic patients usually suffer peritoneum effusion, which severely compromises quality life. Great efforts have been made concerning treatment including with β‑elemene. Although peritoneal perfusion β‑elemene attenuates progression malignant effusion without severe adverse effects in clinic, underlying molecular mechanism activity against unclear. In present study, a network pharmacology approach was undertaken to...
Magnolol is a pharmacological biphenolic compound extracted from Chinese herb Magnolia officinalis, which displays anti-inflammatory and antioxidant effects. This study was aimed at exploring the potential effect of magnolol on immune-related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA, 8 mg/kg/week) up to 6 weeks establish hepatic fibrosis, (10, 20, 30 mg/kg/day) given these orally throughout whole experiment. We found that preserved function attenuated...
Patients with unresectable locally advanced pancreatic cancer (LAPC) are still in dire need of effective therapies. We performed this cohort study order to assess the efficacy and safety high-intensity focused ultrasound (HIFU) ablation treating patients LAPC.Eighty-seven cases LAPC from January 2014 December 2016 were finally recruited according inclusion criteria. The primary end point our was OS all cases, secondary points included 6-month 12-month survival rate, tumor response...
Myocardial fibrosis is a major complication of diabetic cardiomyopathy (DCM) that primarily caused by cardiac fibroblasts are highly activated persistent hyperglycemic stimulation, resulting in excessive collagen deposition. Calcium sensing receptor (CaSR) member the G protein‑coupled superfamily and regulates intracellular calcium concentrations, which associated with numerous diseases, including myocardial infarction, tumors pulmonary hypertension. However, whether CaSR participates...
Background: Damage to the intestinal barrier often occurs following severe trauma. It has been reported that enteral nutrition with dietary fiber (DF) could mitigate impairment of and might therefore be effective in clinical application; however, conclusions from existing trials are controversial nature protective mechanism is far clear. This study investigated on rats under bilateral closed femur fracture. Methods: Twenty-four Sprague-Dawley were divided into four groups: normal control...
Abstract Backgrounds/aims Ras is a control switch of ERK1/2 pathway, and hyperactivation Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by activation still unclear. This work aimed to reveal whether promoted development colorectal cancer via regulating H3K9ac. Methods A vector for expression K-Ras mutated at G12 V T35S was transfected into SW48 cells, acetylation H3K9 measured Western blot analysis. MTT assay, colony formation transwell...
Although acute rejection (AR) can be significantly improved by effective immunosuppressants, such as FK506, chronic (CR) remains a major hurdle to long-term allograft survival after small bowel transplantation, in part because the pathogenic mechanisms of CR are, yet, unknown. The rat orthotopic transplantation (OSBT) model has been used few researchers, but without survival.Rats were randomly divided into five groups: Group 1 (n=20), sham-operation rats; 2 Lewis Lewis; 3 F344 treated with...