A5100434423- Mitochondrial Function and Pathology
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Cancer-related gene regulation
- Silk-based biomaterials and applications
- Receptor Mechanisms and Signaling
- Microbial Metabolic Engineering and Bioproduction
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Plant biochemistry and biosynthesis
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Nitrogen and Sulfur Effects on Brassica
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Plant Gene Expression Analysis
- Plant Micronutrient Interactions and Effects
- Plant Molecular Biology Research
- Polydiacetylene-based materials and applications
- Peptidase Inhibition and Analysis
- Microbial Community Ecology and Physiology
Zhongshan Hospital
2022-2025
Sichuan University
2023-2025
Fudan University
2021-2025
Chongqing University
2025
University of Science and Technology Beijing
2025
Xijing Hospital
2021-2024
China West Normal University
2024
Shanghai Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Anhui Normal University
2024
// Shuli Liu 1, 2 , Dongxia Ye 1 Wenzheng Guo Wenwen Yu Yue He Jingzhou Hu Yanan Wang Ling Zhang Yueling Liao 2, 3 Hongyong Song Shuangshuang Zhong Dongliang Xu Huijing Yin Beibei Sun 4 Xiaofei Jingyi 5 Yadi Wu Binhua P. Zhou Zhiyuan Jiong Deng 3, Department of Oral and Maxillofacial–Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, China Key Laboratory Cell Differentiation Apoptosis Chinese Minister Education, for Tumor Microenvironment...
Abstract BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated transcription is required tumor cells to develop drug resistance. Our data show prolonged treatment luminal breast with AKT inhibitors induces FOXO3a dephosphorylation, nuclear translocation, disrupts its association SirT6, eventually leading acetylation as well recognition. Acetylated...
Neuronal mitochondria dysfunction and neuroinflammation are two prominent pathological features increasingly realized as important pathogenic mechanisms for neurodegenerative diseases. However, little attempt has been taken to investigate the likely interactions between them. Mitofusin2 (Mfn2) is a mitochondrial outer membrane protein regulating fusion, dynamic process essential function. To explore significance of neuronal in regulation neuroinflammation, male female transgenic mice with...
Abstract Summary We describe eMPRess, a software program for phylogenetic tree reconciliation under the duplication-transfer-loss model that systematically addresses problems of choosing event costs and selecting representative solutions, enabling users to make more robust inferences. Availability implementation eMPRess is freely available at http://www.cs.hmc.edu/empress. Supplementary information data are Bioinformatics online.
Inadequate vascularization significantly hampers wound recovery by limiting nutrient delivery. To address this challenge, we extracted membrane vesicles from Lactobacillus reuteri (LMVs) and identified their angiogenic potential via transcriptomic analysis. We further developed a composite hydrogel system (Gel-LMVs) anchoring LMVs within carboxylated chitosan cross-linking it with oxidized hyaluronic acid through Schiff base reaction. The resulting Gel-LMVs exhibit good biocompatibility...
Strawberries emit hundreds of different volatiles, but only a dozen, including the key compound HDMF [4-hydroxy-2,5-dimethyl-3(2H)-furanone] contribute to flavor fruit. However, during ripening, considerable amount is metabolized flavorless β-d-glucoside. Here, we functionally characterize nine ripening-related UGTs (UDP-glucosyltransferases) in Fragaria that function glucosylation volatile metabolites by comprehensive biochemical analyses. Some showed rather broad substrate tolerance and...
Summary Physiologically active acylphloroglucinol ( APG ) glucosides were recently found in strawberry Fragaria sp.) fruit. Although the formation of aglycones has been clarified, little is known about glycosylation plants. In this study we functionally characterized ripening‐related glucosyltransferase genes by comprehensive biochemical analyses encoded proteins and a RNA interference i) approach vivo . The allelic UGT 71K3a/b catalyzed glucosylation diverse hydroxycoumarins, naphthols...
Glycosylation determines the complexity and diversity of plant natural products. To characterize fruit ripening-related UDP-dependent glycosyltransferases (UGTs) functionally in strawberry, we mined publicly available Fragaria vesca genome sequence found 199 putative UGT genes. Candidate UGTs whose expression levels were strongly up-regulated during ripening cloned from F.×ananassa six successfully expressed Escherichia coli biochemically characterized. UGT75T1 showed very strict substrate...
Eriodictyol is a bioactive flavonoid compound that shows potential applications in medicine development and food processing. Microbial synthesis of eriodictyol has been attracting increasing attention due to several benefits. In this study, we employed GRAS strain Corynebacterium glutamicum as the host produce directly from tyrosine.We firstly optimized biosynthetic module naringenin, upstream intermediate for production, through screening different gene orthologues. Next, improve level...
Regulating macrophage phenotypes to reconcile the conflict between bacterial suppression and tissue regeneration is ideal for treating infectious skin wounds. Here, an injectable immunoregulatory hydrogel (SrmE20) that sequentially drives phenotypic polarization (M0 M1, then M2) was constructed by integrating anti-inflammatory components proinflammatory solvents.
Skin has a protein microenvironment dominated by functional collagen fibers, while oxidative stress caused injury can greatly slow down the progress of wound healing. Here, methacrylated dopamine was incorporated into silk fibroin molecule chains to develop an injectable hydrogel with photocuring properties for constructing antioxidant skin microenvironment. This fibroin-based (SF-
Immune checkpoint inhibitor (ICI) therapy is a promising anti-tumor therapeutic strategy; however, its efficacy in solid tumors limited. Chromosome missegregation common various tumors; role tumor progression remains poorly understood, and correlation with ICI yet to be explored. Here, it found that increased chromosome promotes immune microenvironment, eventually immunotherapeutic efficacy, by triggering pyroptosis. yin yang 2 (YY2) identified as mitotic regulator, which upregulating BUB1B...
Traditional thermal switches usually suffer from long-time and unidirectional response. Herein, we combined liquid metals with magnetic Ni2Mn1.4In0.6 particles developed a thermomagnetic metal. These materials not only show excellent fluidity electrical conductivity, but also exhibit fast response at tuneable temperature that traditional do have. The ultimate application is designed as micro-channel switch. Particularly, our switch features bidirectional through the droplet displacement,...
Abstract Tumors use a wide array of immunosuppressive strategies, such as reducing the longevity and survival dendritic cells (DCs), to diminish immune responses limit effect immunotherapy. In this study, we found that tumors upregulate expression multiple microRNAs (miRNAs), miR-16-1, miR-22, miR-155, miR-503. These tumor-associated miRNAs influenced DCs by affecting molecules are associated with apoptotic signaling pathways. Specifically, miR-22 targeted YWHAZ interrupt PI3K/Akt MAPK...
Abstract RNA interference (RNAi) represents a promising strategy for the treatment of HCV infection. However, development an effective system in vivo delivery small interfering (siRNA) to target organ remains formidable challenge. Here, we develop unique nanoparticle platform (VE-DC) composed α-tocopherol (vitamin E) and cholesterol-based cationic liposomes (DOTAP-Chol) systemic siRNAs liver. A HCV-replicable cell line, Huh7.5.1-HCV transient core expressing Huh7.5.1-Core, were constructed...
Abstract Overactivated inflammatory reactions hinder the bone regeneration process. Timely transformation of microenvironment from pro‐inflammatory to anti‐inflammatory after acute immune response is favorable for osteogenesis. Macrophages play an important role in inflammation. Therefore, this study adopts TIM3 high expression extracellular vesicles (EVs) with immunosuppressive function reshape early injury, mainly by targeting macrophages. These EVs can be phagocytosed macrophages, thereby...