A5101566854- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- Flavonoids in Medical Research
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Urologic and reproductive health conditions
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Ureteral procedures and complications
- RNA regulation and disease
- Prostate Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Kidney Stones and Urolithiasis Treatments
- Protein Degradation and Inhibitors
Zhejiang University
2012-2024
First Affiliated Hospital Zhejiang University
2013-2024
County Hospital
2023
University of Kentucky
2010-2022
University of Minnesota Medical Center
2022
Markey Cancer Center
2010-2022
Cancer Hospital of Shantou University Medical College
2021
Shantou University
2021
Shantou University Medical College
2021
University of Minnesota
2009-2021
Abstract Snail1, a key transcription factor of epithelial–mesenchymal transition (EMT), is subjected to ubiquitination and degradation, but the mechanism by which Snail1 stabilized in tumours remains unclear. We identify Dub3 as bona fide deubiquitinase, interacts with stabilizes Snail1. overexpressed breast cancer; knockdown resulted destabilization, suppressed EMT decreased tumour cell migration, invasion, metastasis. These effects are rescued ectopic expression. IL-6 also inducing...
Abstract BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated transcription is required tumor cells to develop drug resistance. Our data show prolonged treatment luminal breast with AKT inhibitors induces FOXO3a dephosphorylation, nuclear translocation, disrupts its association SirT6, eventually leading acetylation as well recognition. Acetylated...
Several studies have indicated that circular RNAs (circRNAs) play vital roles in the progression of various diseases, including bladder cancer (BCa). However, underlying mechanisms by which circRNAs drive BCa malignancy remain unclear. In this study, we identified a novel circRNA, circPSMA7 (circbaseID:has_circ_0003456), showing increased expression cell lines and tissues, integrating reported information with circRNA-seq qRT-PCR. We revealed is associated higher tumor grade stage BCa. M
Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study to investigate the effect and mechanism apigenin human bladder cancer cell line T24 for first time.T24 cells were treated with varying concentrations time apigenin. Cell viability evaluated by MTT assay. motility invasiveness assayed Matrigel migration invasion Flow cytometry western blot analysis used detect apoptosis, cycle signaling pathway.The results demonstrated that...
Abstract Introduction During the last decades, advent of flexible ureteroscopic lithotripsy has revolutionized management upper urinary tract stones. We designed a patented tip-bendable ureteral access sheath to facilitate stone clearance. Our current study reported our initial experience 224 cases. Materials and methods The is descriptive, retrospective analysis. cases, operated consecutively by one surgeon during 16 months, were reviewed. novel was applied in procedure. Demographics,...
The mortality rate associated with prostate cancer is mainly due to metastases rather than primary organ‑confined disease. Decreasing the incidence of metastasis important in treating cancer. 4',5,7‑trihydroxyflavone (apigenin) has been demonstrated be effective inhibiting several types aim this study was investigate effect and mechanism apigenin on movement cells. In present study, DU145 cells were treated varying concentrations for different time periods. Cell viability evaluated using an...
p53 is the most frequently mutated tumor-suppressor gene in human cancers. It has been reported that mutations result not only loss of its ability as a tumor suppressor, but also gain novel cancer-related functions contribute to oncogenesis. The present study evaluated potential silencing mutant by small interfering RNA treatment bladder cancer cells vitro.We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay assess cell viability and flow cytometry detect cycle...
Abstract Bladder cancer (BCa) is the one of most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially miRNA cluster in this involved several pathologic processes various cancers, miR-323a-3p a member cluster. In study, we investigate function regulatory network BCa. frequently downregulated BCa tissues three cell lines compared adjacent non-tumorous bladder normal line (SV-HUC-1). Besides,...
The epithelial-mesenchymal transition (EMT) represents a cellular de-differentiation process that provides cells with the increased plasticity required during embryonic development, tissue remodeling, wound healing and metastasis. Slug Twist are two key EMT transcription factors (EMT-TFs) tightly regulated via ubiquitination degradation. How escape degradation become stabilized in cancer remains unclear. One plausible mechanism of stabilization involves removal ubiquitin by deubiquitinases...
Renal fibrosis acts as the common pathway leading to development of end-stage renal disease. The present study investigated, in vivo and vitro, anti-fibrotic anti-inflammatory effects, particularly on epithelial mesenchymal transition tubular cells, exerted by honokiol, a phytochemical used traditional medicine, mechanisms underlying these effects.Anti-fibrotic effects were assayed rat model [the unilateral ureteral obstruction (UUO) model]. A cell line (NRK-52E) was stimulated transforming...
Resveratrol, which is highly concentrated in the skin of grapes and abundant red wine, has been demonstrated to account for several beneficial properties, including antioxidant, anticoagulant, anti-inflammatory anticancer effects. Taxol a microtubule-stabilizing drug that extensively used as effective chemotherapeutic agents treatment solid tumors. Here, we investigated whether combination two compounds would yield increased antitumor efficacy human cancer cells. Unexpectedly, resveratrol...
Bladder cancer is the fourth most common in males and ninth females. However, despite numerous advances made past few decades, prognosis of patients with bladder remains poor. Metastasis one major causes mortality patients. Therefore, inhibition metastasis significant issues research. The present study was conducted to evaluate anti-metastatic potential (-)-epigallocatechin gallate (EGCG, phytochemical green tea) against its mechanism action. EGCG efficiently dose-dependently inhibited...
The transcription factor Snail not only functions as a master regulator of epithelial–mesenchymal transition (EMT), but also mediates cell proliferation and survival. While previous studies have showed that protects tumor cells from apoptosis through transcriptional repression PTEN, the specific mechanism remains unclear. In this study, we demonstrated cooperates with LSD1 to repress PTEN in PARP1-dependent manner. Upon doxorubicin treatment, becomes tightly associated PARP1 its...
Recent studies have reported that double-stranded RNA (dsRNA) can activate gene expression by targeting promoter sequence in a process termed activation. The present study was conducted to evaluate the potential of WT1 induction small activating (dsWT1) treatment hepatocellular carcinoma.The human carcinoma cell line HepG2 transfected with dsRNA liposomes. mRNA and protein cells were investigated using real-time reverse quantitative PCR Western blot, respectively. Cell viability...