A5100398601- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Traditional Chinese Medicine Studies
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Nuts composition and effects
- Kruppel-like factors research
- Pharmacological Effects of Natural Compounds
- Perovskite Materials and Applications
- Viral Infections and Vectors
- Click Chemistry and Applications
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
Chinese University of Hong Kong, Shenzhen
2024
The University of Texas MD Anderson Cancer Center
2021-2024
Wuhan University
2022-2024
Beijing University of Chinese Medicine
2023
Affiliated Hospital of Hebei University
2023
University of Chinese Academy of Sciences
2014-2022
Zhejiang University
2022
Northwest A&F University
2022
Shenzhen University
2022
Shanghai Sixth People's Hospital
2022
Abstract M icroRNAs (miRNAs) are important regulators in gene expression. The dysregulation of miRNA expression is widely reported the transformation from physiological to pathological states cells. A large number differentially expressed miRNAs (DEMs) have been identified various human cancers by using high-throughput technologies, such as microarray and miRNA-seq. Through mining published studies with experiment information, database DEMs (dbDEMC) was constructed aim providing a systematic...
Four A-D-A type small molecules using 4,4,9,9-tetrakis(4-hexylphenyl)- indaceno[1,2-b:5,6-b′]dithiophene as central building block, bithiophene or terthiophene π-bridges, alkyl cyanoacetate rhodanine end acceptor groups were synthesized and investigated electron donors in solution-processed organic solar cells (OSCs). These showed excellent thermal stability with decomposition temperatures over 360 °C, relatively low HOMO levels of −5.18 to −5.22 eV, strong optical absorption from 350 670 nm...
Bladder cancer (BCa) is a heterogeneous disease with various tumorigenic mechanisms and clinical behaviors.The current tumor-node-metastasis (TNM) staging system inadequate to predict overall survival (OS) in BCa patients.We developed BCa-specific, long-non-coding-RNA (lncRNA)-based nomogram improve prediction BCa.We obtained the large-scale gene expression profiles of samples from 414 patients The Cancer Genome Atlas database.Using an lncRNA-mining computational framework, we identified...
Ephrin receptor A2 (EphA2), a member of the family, is closely related to progression oral squamous cell carcinoma (OSCC). Cancer stem cells (CSCs) play essential roles in OSCC development and occurrence. The underlying mechanisms between EphA2 CSCs, however, are not yet fully understood. Here, we found that was overexpressed tissues associated with poor prognosis. Knockdown dampened CSC phenotype tumour-initiating frequency cells. Crucially, effects on relied KLF4, key transcription factor...
MicroRNAs(miRNAs) are key regulators of gene expression in plants, animals and some viruses. Hence, alteration miRNA levels cells or tissues is common for studies. Loss-of-function can be achieved using antisense oligonucleotides, sponges knockout models.Here, we showed an efficient, rational economical way to construct multi-targeted with desired copies. Four copies sponge used as "building-blocks".These building-blocks, which target same different miRNAs, linked together through ligation....
The natural products combretastatin A-1 (CA1) and A-4 (CA4) function as potent inhibitors of tubulin polymerization selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can enhance selectivity by serving substrates for reductase enzymes specifically hypoxic regions A series CA1-BAPCs incorporating nor-methyl, mono-methyl, gem-dimethyl nitrothiophene triggers were synthesized together with corresponding CA4-BAPCs, previously reported...
Oral cancer is one of the leading causes death worldwide, with a reported 5‑year survival rate ~50% after treatment. The treatment measures for oral are very expensive and affordability low. Thus, it necessary to develop more effective therapies treat cancer. A number studies have found that miRNAs invasive biomarkers therapeutic potential in variety cancers. present study included 30 patients healthy controls. Clinicopathological characteristic miR‑216a‑3p/β‑catenin expression level were...
Ferroptosis, a regulated form of cell death characterized by excessive iron-dependent lipid peroxidation, can be readily induced in cultured cells chemicals such as erastin and RSL3. Protein disulfide isomerase (PDI) has been identified an upstream mediator chemically ferroptosis also target for protection. In this study, we discovered that raloxifene (RAL), selective estrogen receptor modulator known its neuroprotective actions humans, effectively inhibit PDI function provide robust...
Abstract Long non‐coding RNA DLX6 antisense 1 (DLX6‐AS1) lists a critical position in thyroid carcinoma (TC) development. However, the overall comprehension about DLX6‐AS1, microRNA (miR)‐193b‐3p and homeobox A1 (HOXA1) TC is not thoroughly enough. Concerning to this, this work pivoted on DLX6‐AS1/miR‐193b‐3p/HOXA1 axis cell growth autophagy. tissues adjacent normal were collected, which expression of miR‐193b‐3p HOXA1 was tested, together with their interactions. cells transfected...
Abstract microRNAs (miRNAs) are important regulators in gene expression. The deregulation of miRNA expression is widely reported the transformation from physiological to pathological state cells. A large amount differentially expressed miRNAs (DEMs) have been identified various human cancers by using high-throughput technologies, such as microarray and miRNA-seq. Through mining published researches with experiment information, database (dbDEMC) was constructed aim providing a systematic...
Deregulations of long non-coding RNAs (lncRNAs) have been implicated in the progression breast cancer (BC). However, prognostic values those lncRNAs BC remain elusive. This study aimed at constructing a lncRNA-based model to improve clinical management BC. Systematic investigation lncRNA expression profiles and data from The Cancer Genome Atlas (TCGA) database were utilized establish 10-lncRNA signature. signature efficiently discriminated patients with significantly different prognosis...
Gastric cancer is one of the most common and deadly types cancer. The molecular mechanism gastric progression remains unclear.Four hub genes were identified through GEO TCGA database screening analysis. Prognostic analysis revealed that COL5A2 was likely to affect prognosis among four genes. relationships between clinical variables immune cell infiltration analyzed. Then, analyzed for single-gene differences related functional enrichment. Using starBase prediction analysis, miRNAs...
ABSTRACT Ferroptosis is a form of regulated cell death characterized by excessive iron-dependent lipid peroxidation. can be induced in cultured cells exposure to certain chemicals ( e.g. , erastin and RSL3). Recently it was shown that protein disulfide isomerase (PDI) mediator chemically-induced ferroptosis also target for protection. In this study, we find bazedoxifene (BAZ), selective estrogen receptor modulator with reported neuroprotective actions humans, inhibit PDI function strongly...
<title>Abstract</title> Ferroptosis, a form of regulated cell death associated with iron-dependent lipid peroxidation, can be induced in cultured cells by chemicals (<italic>e.g.</italic>, erastin and RSL3). It has been shown that protein disulfide isomerase (PDI) is mediator chemically-induced ferroptosis also crucial target for protection. The present study reports bazedoxifene (BAZ), selective estrogen receptor modulator, an inhibitor PDI strongly protect against neuronal cells. We find...
Recent studies have shown that the activation of innate immune sensor cyclic GMP–AMP synthase–stimulator interferon genes (cGAS-STING) promotes antigen presentation and T-cell activation, thus transforming cold tumors to immunologically responsive tumors. However, because STING is a cytosolic protein key mediator inflammation, needs be specific antigen-presenting cells (APCs) in tumor tissues. To address this technical challenge meet clinical need, we developed technology termed MUSIC...
Abstract Viral infectious diseases (VIDs) impose a heavy burden on global public health. Traditional Chinese medicine (TCM) has previously and is currently contributing to the prevention treatment of diseases. Omics information technology enable precise identification virus characteristics, virus‒host interactions TCM mechanisms. In this study, we constructed YiNet platform better integrate novel techniques historical experience in comprises three modules: knowledge base, database toolkit....
The innate immune sensor cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS-STING) has recently emerged as a potential therapeutic target to boost antitumor responses. However, STING is cytoplasmic protein, and its natural activator cGAMP negatively charged dinucleotide that difficult deliver intracellularly. We have developed new platform called Microbubble-assisted UltraSound (US)-guided Immunotherapy Cancer (MUSIC) activate with spatio-temporal control treat cancer. MUSIC showed...