A5041696120- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Protease and Inhibitor Mechanisms
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Crystallography and molecular interactions
- Bone Metabolism and Diseases
- Synthetic Organic Chemistry Methods
- Ubiquitin and proteasome pathways
- Renal Transplantation Outcomes and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Organic Compounds
- Chemical Synthesis and Analysis
- Photoacoustic and Ultrasonic Imaging
- Trypanosoma species research and implications
- Estrogen and related hormone effects
- Photodynamic Therapy Research Studies
- Bone health and treatments
- Chemistry and Chemical Engineering
Baylor University
2016-2025
PAX Scientific (United States)
2022-2024
Mateon Therapeutics (United States)
2016
University of Surrey
2011
In-Q-Tel
2011
Arizona State University
2008
National Cancer Institute
2000
University of Illinois Urbana-Champaign
1990-1992
Urbana University
1991
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective synthesis of 2,5-dihydrofurans by sequential SN2' cleavage alkynyloxiranes and silver(I)-catalyzed cyclization the allenylcarbinol productsJames A. Marshall Kevin G. PinneyCite this: J. Org. Chem. 1993, 58, 25, 7180–7184Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December...
BackgroundMolecular testing with gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) is increasingly used in the surveillance for acute cellular rejection (ACR) after heart transplant. However, performance of dual over each test individually has not been established. Further, impact non-invasive on clinical decision-making widely investigated.MethodsWe evaluated 2077 subjects from SHORE registry who were enrolled between 2018 2021 had verified biopsy data, categorized...
Journal Article A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment Get access Ralph P. Mason, Mason Department of Radiology, The University Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9058, USA Search for other works by this author on: Oxford Academic Google Scholar Dawen Zhao, Zhao Li Liu, Liu Mary Lynn Trawick, Trawick Chemistry Biochemistry, Baylor University, One Bear Place #97348,...
The natural products colchicine and combretastatin A-4 are potent inhibitors of tubulin assembly, they have inspired the design synthesis a large number small-molecule, potential anticancer agents. indole-based molecular scaffold is prominent among these SAR modifications, leading to rapidly increasing water-soluble phosphate prodrug 33 (OXi8007) 2-aryl-3-aroylindole-based phenol 8 (OXi8006) was prepared by chemical found be strongly cytotoxic against selected human cancer cell lines (GI₅₀ =...
Abstract The mechanism of tumor cell killing by OXI4503 was investigated studying vascular functional and morphological changes post drug administration. SCID mice bearing MHEC5‐T hemangioendothelioma were given a single dose at 100 mg/kg. Tumor blood flow, measured microsphere fluorescence, reduced 50% 1 hr, reached maximum level 6–24 hr treatment. permeability, Evan's blue hemoglobin, increased significantly from 3 peaked 18 hr. elevated vessel permeability accompanied an increase in...
Synthesis of benzocyclooctene and indene analogues inspired by colchicine combretastatin A-4.
There has been much progress in treating kidney cancer, with several new drugs being approved over the last few years [...].
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of a tetrafluoro-substituted aryl azide and its protio analog as photoaffinity labeling reagents for the estrogen receptorKevin G. Pinney John A. KatzenellenbogenCite this: J. Org. Chem. 1991, 56, 9, 3125–3133Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/jo00009a037https://doi.org/10.1021/jo00009a037research-articleACS PublicationsRequest...
Several stilbenoid compounds having structural similarity to the combretastatin group of natural products and characterized by incorporation two nitrogen-bearing groups (amine, nitro, serinamide) have been prepared chemical synthesis evaluated in terms biochemical biological activity. The 2′,3′-diamino B-ring analogue 17 demonstrated remarkable cytotoxicity against selected human cancer cell lines vitro (average GI50 = 13.9 nM) also showed good activity regard inhibition tubulin assembly...
A series of 36 thiosemicarbazone analogues containing the thiochromanone molecular scaffold functionalized primarily at C-6 position were prepared by chemical synthesis and evaluated as inhibitors cathepsins L B. The most promising from this group are selective for cathepsin demonstrate IC50 values in low nanomolar range. In nearly all cases, sulfide show superior inhibition compared to their corresponding sulfone derivatives. Without exception, compounds inactive (IC50 > 10000 nM) against...