A5066729117- Advanced biosensing and bioanalysis techniques
- Organic Light-Emitting Diodes Research
- Electrochemical Analysis and Applications
- Luminescence and Fluorescent Materials
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Electrochemical sensors and biosensors
- Plant-derived Lignans Synthesis and Bioactivity
- Metal complexes synthesis and properties
- Biological and pharmacological studies of plants
- Conducting polymers and applications
- Molecular Junctions and Nanostructures
- Molecular Sensors and Ion Detection
- Biosensors and Analytical Detection
- Bioactive natural compounds
- Analytical Chemistry and Sensors
- Plant Toxicity and Pharmacological Properties
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Trypanosoma species research and implications
- Advanced Biosensing Techniques and Applications
- Synthesis and Biological Evaluation
- Alkaloids: synthesis and pharmacology
- Dendrimers and Hyperbranched Polymers
Chinese Academy of Sciences
2012-2025
First Affiliated Hospital of Kunming Medical University
2024-2025
Kunming Medical University
2024-2025
Wuhan Botanical Garden
2020-2025
Huazhong University of Science and Technology
2015-2023
Central South University
2014-2022
Mianyang Third People's Hospital
2022
Beijing Emergency Medical Center
2022
Nantong University
2020-2021
Affiliated Hospital of Nantong University
2020-2021
The cellular behavior and toxicity effect of organometallic complexes depend largely on their peripheral ligands. In this study, we have synthesized a series novel luminescent cationic iridium(III) by tuning the ancillary N(∧)N ligand based structure [Ir(ppy)2(N(∧)N)](+) (ppy = 1-phenyl-pyridine; 2,2'-bipyridine (bpy, 1) or phenanthroline (phen, 2) 4,7-diphenyl-1,10- (DIP, 3)). As size coordinated increases, absorbance/emission efficiency, quantum yields, lipophilicity, cell uptake rates...
Mutations in the adult human skeletal muscle Na + channel a subunit cause disease paramyotonia congenita. Two congenita mutations, R1448H and R1448C, substitute histidine cysteine for arginine S4 segment of domain 4. These expressed cell line, have only small effects on activation Na+ currents, but mutant channels inactivate more slowly with less voltage dependence than wild-type exhibit an enhanced rate recovery from inactivation. Increase extracellular pH made inactivation RI 448H similar...
Lighting up the cell: Peptides that are site-specifically labeled with a luminescent iridium(III) complex at histidine residues can penetrate cell membranes effectively, showing intracellular distribution and efficient mitochondrial targeting (see figure, CPP=cell-penetrating peptide, MTS=mitochondria-targeting sequences). Detailed facts of importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Tuberculosis (TB) remains one of the leading causes morbidity and mortality all over world multidrug resistance TB (MDR-TB) pose a serious threat to control represent an increasing public health problem. In this work, we report homogeneous signal-on electrochemiluminescence (ECL) DNA sensor for sensitive specific detection rpoB genes MDR-TB by using ruthenium(II) complex functionalized graphene oxide (Ru–GO) as suspension sensing interface ferrocene-labeled ssDNA (Fc–ssDNA) ECL intensity...
Centipedes can subdue giant prey by using venom, which is metabolically expensive to synthesize and thus used frugally through efficiently disrupting essential physiological systems. Here, we show that a centipede ( Scolopendra subspinipes mutilans , ∼3 g) mouse (∼45 within 30 seconds. We found this observation largely due peptide toxin in the SsTx, further established SsTx blocks KCNQ potassium channels exert lethal toxicity. also demonstrated opener, retigabine, neutralizes toxicity of...
Under well-controlled conditions, different polypyrrole variants can be galvanostatically prepared in acetonitrile + 1% H2O by changing the current density. At densities down to 0.25 mA/cm2, PPy(I) is electrosynthesized; at lower densities, a mixture of and PPy(II) generated. In presence small amount acid (∼1 × 10-5 M), exclusively formed. The availability well-defined materials enables us perform further reliable characterization EQCM. results reveale natures ionic transport when PPy are...
Five iridium(III) complexes with two N-heterocyclic carbene (NHC) ligands and an ancillary ligand have been designed successfully synthesized. With multicolor photoluminescence low toxicity, these were tested, for the first time, as living cell imaging reagents showed promise application beyond OLED (organic light emitting diode) area.
Sky-blue homoleptic iridium(<sc>iii</sc>) complexes with phenylimidazole ligands show consistent behavior that is linked to their ligand conjugation.
In acetonitrile electropolymerization of pyrrole is considerably facilitated by the addition a small amount water. Several mechanisms have been suggested in past to interpret this dramatic influence However, none them has explained all experimental results obtained up now. On basis mechanism involving acid-catalyzed formation trimer, 2,2‘-(2,5-pyrrolidinediyl)dipyrrole and its subsequent leading electrode passivation, it proposed that water, fairly strong base acetonitrile, prevents trimer...
Ultrasensitive bioanalytical assays are of great value for early detection human diseases and pathogens. The sensitivities immunoassays DNA probing can be enhanced by multilabeling the biorecognition partner used affinity-based assays. However, bioreactivity biomolecules is affected a high degree at multiple functional sites. It proposed that dendritic scaffoldings to link signal-generating units single site with potentially minimum impact on bioaffinity. A prototype label, zeroth-generation...
Several [Ru(bpy)3]2+ (bpy = 2,2'-bipyridine and its derivatives) complexes were synthesized compared electrochemically spectroscopically in the search for better luminophores electrochemiluminescence (ECL)-based analytical applications. ECL measurement [Ru(bpy)3]2+/tripropylamine (TPA) aqueous buffer solutions has led to a conclusion that due complexity of generation process, photoluminescence efficiency cannot be used predict intensity there is no obvious relationship between quantum yield...
Two series of (dfppy)2Ir(LN^O) with different substituents were designed and successfully synthesized the effect substitution at ancillary ligand on photophysical electrochemical properties investigated. The results indicate that electron-donating group –OMe LN^O increases PL quantum efficiencies electron-withdrawing groups –CF3 –F lower efficiencies.
A series of cyclometalated iridium(III) complexes with 2-phenylquinoline ligand (1-4) were designed and synthesized, which thoroughly investigated by the photophysics, electrochemistry, theoretical calculations electrochemiluminescence (ECL). By incorporating methyl groups into 2-phenylquinoline, corresponding 2 3 displayed lower oxidative potential higher HOMO energy levels. Most importantly, compared tris(2,2'-bipyridyl)ruthenium(II) ([Ru(bipy)3](2+)), these demonstrated more intense ECL...
Euphorbia peplus has been used in traditional medicine to treat asthma and psoriasis. Three highly modified diterpenoids, namely, pepluacetal (1) pepluanol A-B (2-3), have isolated identified from this plant. Compounds 1-3 exhibit unprecedented 5/4/7/3, 5/6/7/3, 5/5/8/3 ring systems, respectively. Their structures with absolute configurations were determined by spectroscopic analyses, X-ray crystallography, electronic circular dichroism calculations. Since Kv1.3 is a validated target for the...
We report the analysis of detached eclipsing spectroscopic binary system LAMOST J101356.33+272410.7, which features a massive white dwarf. Using and SDSS spectra, we determined stellar parameters radial velocities both components. SED fitting photometric data from GALEX, 2MASS, Pan-STARRS1 yielded effective temperatures radii. Eclipsing high-speed Liverpool Telescope provided orbital inclination, masses, radii, related physical parameters. The dwarf in this has mass $1.05 \pm 0.09 \,...
There is a severe shortage of intensive care nurses worldwide, and training qualified ICU nurse hard since it takes very long time to accumulate the knowledge skills needed. This study aimed examine effect an escape room teaching method on teamwork attitudes new nurses, their satisfaction with, willingness participate in training. A convenience sampling approach was utilized enlist from April 2023 March 2024 China. with less than two years experience First Affiliated Hospital Kunming Medical...
A supramolecular assembly with eight peripheral ruthenium(II) tris(bipyridine), [Ru(bpy)3]2+, units covalently linked to a carbosilane dendrimer platform has been synthesized. 1H NMR and MALDI-TOF mass spectrometry confirm the target structure. Spectroscopic electrochemical studies disclose that identical [Ru(bpy)3]2+ in this system interact neither ground state nor excited state. In acetonitrile solutions of molar concentration units, both reference monomeric...