A5083611896- Monoclonal and Polyclonal Antibodies Research
- Receptor Mechanisms and Signaling
- Prostate Cancer Treatment and Research
- Speech Recognition and Synthesis
- CAR-T cell therapy research
- Protein Kinase Regulation and GTPase Signaling
- Speech and Audio Processing
- Immune cells in cancer
- Computational Drug Discovery Methods
- Cancer Research and Treatments
- Music and Audio Processing
- Radiopharmaceutical Chemistry and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Proteomics Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Speech and dialogue systems
- Natural Language Processing Techniques
- Virus-based gene therapy research
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Eicosanoids and Hypertension Pharmacology
- Generative Adversarial Networks and Image Synthesis
Pfizer (United States)
2021-2025
Zhejiang University
2023-2025
Southeast University
2022-2023
ImmunityBio (United States)
2022
Global Science & Technology (United States)
2021
ImaginAb (United States)
2016-2020
University of California, Los Angeles
2010-2019
California NanoSystems Institute
2016
Indiana University – Purdue University Indianapolis
2011
Indiana University School of Medicine
2011
Growing evidence suggests that tumor-associated macrophages (TAM) promote cancer progression and therapeutic resistance by enhancing angiogenesis, matrix-remodeling, immunosuppression. In this study, prostate under androgen blockade therapy (ABT) was investigated, demonstrating TAMs contribute to disease recurrence through paracrine signaling processes. ABT induced the tumor cells express macrophage colony-stimulating factor 1 (M-CSF1 or CSF1) other cytokines recruit modulate macrophages,...
Abstract Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes quality life patients. known consequence vascular dysfunction, but current approved treatments are not effective preventing fluid accumulation. In this study, we investigated an alternative strategy targeting macrophage functions to reverse pathology malignant using from human patients and immunocompetent murine model (ID8) EOC mirrors disease by developing...
Generating photo-realistic video portrait with arbitrary speech audio is a crucial problem in film-making and virtual reality. Recently, several works explore the usage of neural radiance field this task to improve 3D realness image fidelity. However, generalizability previous NeRF-based methods out-of-domain limited by small scale training data. In work, we propose GeneFace, generalized high-fidelity talking face generation method, which can generate natural results corresponding various...
A pretargeted oncologic positron emission tomography (PET) imaging that leverages the power of supramolecular nanoparticles with in vivo bioorthogonal chemistry was demonstrated for clinically relevant problem tumor imaging. The advantages this approach are (i) pharmacokinetics (PKs) tumor-targeting and agents can be independently altered via chemical alteration to achieve desired performance (ii) interplay between two PKs other controllable variables confers a second layer control toward...
CD8-expressing T cells are the main effector in cancer immunotherapy. Treatment-induced changes intratumoral CD8+ may represent a biomarker to identify patients responding Here, we have used 89Zr-radiolabeled human CD8-specific minibody (89Zr-Df-IAB22M2C) monitor T-cell tumor infiltrates by PET. The ability of this tracer quantify was evaluated preclinical studies following single-agent treatment with FOLR1-T-cell bispecific (TCB) antibody and combination therapy CEA-TCB (RG7802)...
Scaling text-to-speech to a large and wild dataset has been proven be highly effective in achieving timbre speech style generalization, particularly zero-shot TTS. However, previous works usually encode into latent using audio codec use autoregressive language models or diffusion generate it, which ignores the intrinsic nature of may lead inferior uncontrollable results. We argue that can decomposed several attributes (e.g., content, timbre, prosody, phase) each them should modeled module...
Abstract Purpose: The inability to visualize cancer during prostatectomy contributes positive margins, recurrence, and surgical side effects. A molecularly targeted fluorescent probe offers the potential for real-time intraoperative imaging. goal of this study was develop a image-guided prostate surgery. Experimental Design: An antibody fragment (cys-diabody, cDb) against stem cell antigen (PSCA) conjugated far-red fluorophore, Cy5. integrity binding PSCA confirmed by gel electrophoresis,...
The correlation between BMP-2 and osteosarcoma growth has gained increased interest in the recent years, however, there is still no consensus. In this study, we tested effects of on cells through both vitro vivo experiments. effect proliferation, migration invasion was vitro. Subcutaneous intratibial tumor models were used for experiments nude mice. EMT Wnt/β-catenin signaling pathway also using a variety biochemical methods. tests did not show significant cell proliferation. However,...
Precise regulation of Type I interferon signaling is crucial for combating infection and cancer while avoiding autoimmunity. negatively regulated by USP18. USP18 cleaves ISG15, an interferon-induced ubiquitin-like modification, via its canonical catalytic function, inhibits receptor activity through scaffold role.
This paper introduces PFlow-VC, a conditional flow matching voice conversion model that leverages fine-grained discrete pitch tokens and target speaker prompt information for expressive (VC). Previous VC works primarily focus on conversion, with further exploration needed in enhancing expressiveness (such as prosody emotion) timbre conversion. Unlike previous methods, we adopt simple efficient approach to enhance the style of models. Specifically, pretrain self-supervised VQVAE discretize...
Abstract A dysregulated cell cycle is a hallmark of cancer and inhibition cyclin dependent kinases (CDKs) proven therapeutic strategy in treating HR+/HER2- breast variety other cancers. 18F-FLT (18F-3'-deoxy-3'-fluorothymidine) validated positron emission tomography (PET) biomarker to measure proliferation. Here we show the utility PET imaging as pharmcodynamic (PD) differentiating efficacy PF-07104091 (CDK2 selective inhibitor) Palbociclib (CDK4/6 sensitive resistant tumor models. was...
Abstract Immune checkpoint inhibitors have shown limited success in breast cancer, the most common and deadly cancer women worldwide. Novel immune therapies like CD3 engaging bispecific antibodies clinical promise hematologic malignancies. However, developing bispecifics for solid tumors has been challenging due to difficulty identifying tumor-specific antigens. B7-H4 is proposed as an attractive tumor-associated antigen therapeutics with comprehensive coverage regardless of molecular...
The inability to intraoperatively distinguish primary tumor, as well lymphatic spread, increases the probability of positive surgical margins, tumor recurrence, and toxicity. goal this study was develop a tumor-specific optical probe for real-time fluorescence-guided surgery.A humanized antibody fragment against PSCA (A11 minibody, A11 Mb) conjugated with near-infrared fluorophore, IRDye800CW. integrity binding were confirmed by gel electrophoresis, size-exclusion chromatography, flow...
Recently, there has been a growing interest in the field of controllable Text-to-Speech (TTS). While previous studies have relied on users providing specific style factor values based acoustic knowledge or selecting reference speeches that meet certain requirements, generating speech solely from natural text prompts emerged as new challenge for researchers. This arises due to scarcity high-quality datasets with prompt and absence advanced text-controllable TTS models. In light this, 1) we...
We report the analysis of detached eclipsing spectroscopic binary system LAMOST J101356.33+272410.7, which features a massive white dwarf. Using and SDSS spectra, we determined stellar parameters radial velocities both components. SED fitting photometric data from GALEX, 2MASS, Pan-STARRS1 yielded effective temperatures radii. Eclipsing high-speed Liverpool Telescope provided orbital inclination, masses, radii, related physical parameters. The dwarf in this has mass $1.05 \pm 0.09 \,...
Abstract Purpose: Prostate stem cell antigen (PSCA) is highly expressed in local prostate cancers and cancer bone metastases its expression correlates with androgen receptor activation a poor prognosis. In this study, we investigate the potential clinical applications of immunoPET anti-PSCA A11 minibody, an antibody fragment optimized for use as imaging agent. We compare minibody to 18F-Fluoride PET scans detecting tumors evaluate ability image tumor response deprivation. Experimental...
Zhenhui Ye, Rongjie Huang, Yi Ren, Ziyue Jiang, Jinglin Liu, Jinzheng He, Xiang Yin, Zhou Zhao. Proceedings of the 61st Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2023.
Abstract Prostate-specific promoters are frequently employed in gene-mediated molecular imaging and therapeutic vectors to diagnose treat castration-resistant prostate cancer (CRPC) that emerges from hormone ablation therapy. Many of the conventional prostate-specific rely on androgen axis drive gene expression. However, considering heterogeneity varying receptor status, we herein evaluated utility enhancing sequence (PSES), an androgen-independent promoter CRPC. The PSES is a fused enhancer...
Zero-shot text-to-speech (TTS) aims to synthesize voices with unseen speech prompts, which significantly reduces the data and computation requirements for voice cloning by skipping fine-tuning process. However, prompting mechanisms of zero-shot TTS still face challenges in following aspects: 1) previous works are typically trained single-sentence restricts their performance when is relatively sufficient during inference stage. 2) The prosodic information prompts highly coupled timbre, making...