A5044682495- Mosquito-borne diseases and control
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- interferon and immune responses
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- vaccines and immunoinformatics approaches
- Diabetes and associated disorders
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
- Spinal Fractures and Fixation Techniques
- Herpesvirus Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Corneal surgery and disorders
- Dermatologic Treatments and Research
Nanjing Agricultural University
2014-2025
First Affiliated Hospital of Xinjiang Medical University
2013-2025
Xinjiang Medical University
2013-2025
Beihang University
2024-2025
Shandong Eye Hospital
2022-2024
Shanxi Medical University
2021-2024
Shandong First Medical University
2022-2024
Shaanxi Provincial People's Hospital
2024
Shanxi University of Finance and Economics
2024
Jinhua Polytechnic
2023
Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitic and emphysematous components. In one biophysical model, the concentration of mucin on airway surfaces hypothesized to be a key variable that controls mucus transport in healthy persons versus cessation with muco-obstructive lung diseases. Under this it postulated high produces sputum progression are characteristic bronchitis.We COPD status 917 participants from Subpopulations Intermediate Outcome Measures...
The cellular behavior and toxicity effect of organometallic complexes depend largely on their peripheral ligands. In this study, we have synthesized a series novel luminescent cationic iridium(III) by tuning the ancillary N(∧)N ligand based structure [Ir(ppy)2(N(∧)N)](+) (ppy = 1-phenyl-pyridine; 2,2'-bipyridine (bpy, 1) or phenanthroline (phen, 2) 4,7-diphenyl-1,10- (DIP, 3)). As size coordinated increases, absorbance/emission efficiency, quantum yields, lipophilicity, cell uptake rates...
In the field of peptide drug discovery, structural constraining and fluorescent labeling are two sought-after techniques important for both basic research pharmaceutical development. this work, we describe an easy-to-use approach simultaneous cyclization luminescent based on iridium(III)–histidine coordination (Ir–HH cyclization). Using a series model peptides with histidine flanking each terminus, binding activity reaction kinetics Ir–HH different ring sizes were characterized. series,...
Chronic lung diseases such as cystic fibrosis, chronic bronchitis, and asthma are characterized by hypersecretion poor clearance of mucus, which associated with prognosis mortality. Little is known about the relationship between biophysical properties mucus its molecular composition. The mucins MUC5B MUC5AC traditionally believed to generate characteristic airway mucus. However, contribution hundreds globular proteins not clear. Approximately one-third total proteome comprises distinct,...
Cationic amphipathic peptides (CAPs) are known to be able cause membrane destabilization and induce cell death, yet how the hydrophobicity, amphipathicity, lysine (K)/arginine (R) composition synergistically affect peptide activity remains incompletely understood. Here, we designed a panel of based on well-known anticancer KLA. Increasing hydrophobicity enhanced cytotoxicities both K- R-rich peptides. Peptides with an intact helical interface can instant death through lysis mechanism....
Mammalian oocyte maturation is distinguished by asymmetric division that regulated primarily cytoskeleton, including microtubules and microfilaments. Small Rho GTPase RhoA a key regulator of cytoskeletal organization which regulates cell polarity, migration, division. In this study, we investigated the roles in mammalian meiosis early embryo cleavage. (1) Disrupting activity or knock down expression caused failure polar body emission. This may have been due to decreased actin assembly...
Mucosal protection of the gallbladder is vital yet we know very little about mechanisms involved. In domestic dogs, an emergent syndrome referred to as mucocele formation characterized by excessive secretion abnormal mucus that results in obstruction and rupture gallbladder. The cause unknown. these first mechanistic studies this disease, investigated normal mucocele-forming dog gallbladders determine source, identity, biophysical properties, protein associates culprit mucins with aim...
Intervertebral disc degeneration (IVDD) is a degenerative and chronic spinal disorder often associated with the older population. Oxidative stress major pathogenic factor of aging that results in apoptosis nucleus pulposus cells (NPCs) extracellular matrix (ECM) degradation. Quercetin (QUE), naturally occurring flavonoid antioxidant anti-inflammatory properties, has been studied research on diseases. However, potential effects mechanisms action QUE IVDD remain unclear. In this study,...
Foreign body response (FBR) to biomaterials compromises the function of implants and leads medical complications. Here, we report a hybrid alginate microcapsule (AlgXO) that attenuated immune after implantation, through releasing exosomes derived from human Umbilical Cord Mesenchymal Stem Cells (XOs). Upon release, XOs suppress local microenvironment, where xenotransplantation rat islets encapsulated in AlgXO led >170 days euglycemia immunocompetent mouse model Type 1 Diabetes. In vitro...
Abstract Corneal injectable hydrogels represent a promising alternative to alleviate donor shortage and simplify traditional surgeries. However, most focus on repairing focal corneal defects (≤3.5 mm) leave many clinical requirements unmet. Herein, novel ion‐activated bioadhesive hydrogel (IonBAH) is designed its long‐term performance of large (6 evaluated in rabbits for 6 months. The IonBAH dual‐network composed natural extracellular matrix peptide‐modified alginate, which enables desirable...
ABSTRACT The host cytoskeleton plays crucial roles in various stages of virus infection, including viral entry, transport, replication, and release. However, the specific mechanisms by which intermediate filaments are involved orthoflavivirus infection have not been well understood. In this study, we demonstrate that Japanese encephalitis (JEV) remodels vimentin network, resulting formation cage-like structures support replication. Mechanistically, JEV NS1 NS1’ proteins induce translocation...
ABSTRACT Orthoflaviviruses remodel the endoplasmic reticulum (ER) network to construct replication organelles (ROs) for RNA replication. In this study, we demonstrate that Japanese encephalitis virus (JEV) NS1 protein concentrates ER membranes in perinuclear region, which provides a substantial membrane source viral Subsequently, forms main within membrane-concentrated area facilitate efficient This process relies on localization signal, glycosylation, dimerization, and membrane-binding...
For the intricate and infrequent safety issues of batteries, online fault diagnosis over stochastic working conditions is indispensable. In this work, we employ deep learning methods to develop an network for lithium-ion batteries operating under unpredictable conditions. The integrates battery model constraints employs a framework designed manage evolution systems, thereby enabling real-time determination. We evaluate performance using dataset 18.2 million valid entries from 515 vehicles....
Intervertebral disc degeneration involves aging and senescence of nucleus pulposus cells (NPCs), JAK/STAT signaling may contribute to this process. The aim study was investigate the therapeutic effect JAK2 inhibitor, ruxolitinib, on NPC senescence. Control (third passage), Senescence (sixth JAK inhibitor (ruxolitinib-treated), siRNA-NC (control siRNA-treated), siRNA-JAK2 (JAK2-targeting siRNA-treated) groups rat NPCs were established. Cell ratios determined by β-galactosidase staining Edu...
Abstract Spinal cord injury (SCI) often occurs in young and middle-aged population. The present study aimed to clarify the function of Galectin-3 (Gal-3) neuroinflammation SCI. Sprague–Dawley (SD) rat models with SCI were established vivo. PC12 cell model vitro was induced by lipopolysaccharide (LPS). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) Gene chip used analyze expression levels genes signaling pathway. Histological assessment, ELISA Western blotting...
Abstract Optimal function of immunoisolated islets requires adequate supply oxygen to metabolically active insulin producing beta‐cells. Using mathematical modeling, we investigated the influence pO 2 on islet secretory capacity and evaluated conditions that could lead development tissue anoxia, modeled for a 300 μm in 500 microcapsule or planar, slab‐shaped macrocapsule. The was used assess part contributed secretion. Assuming macrocapsule with islet, consumption rate (OCR) 100–300 nmol min...