A5100457986- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Chronic Lymphocytic Leukemia Research
- Venous Thromboembolism Diagnosis and Management
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Cardiac Health and Mental Health
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Health Systems, Economic Evaluations, Quality of Life
- Hematological disorders and diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Glioma Diagnosis and Treatment
Sichuan University
2020-2025
West China Hospital of Sichuan University
2020-2025
Jiangjin Central Hospital
2024-2025
Chongqing University
2024-2025
Chongqing Medical University
2015-2024
Second Affiliated Hospital of Chongqing Medical University
2016-2024
Dalian Medical University
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
First People's Hospital of Yunnan Province
2024
Kunming University of Science and Technology
2024
The present study focused on the action mechanism of S. pneumoniae (Sp) in inducing autophagy human alveolar epithelial cells. Sp, a gram-positive extracellular bacterium, activates with considerably increased microtuble-associated protein light chain 3 (LC3) punctation A549 accumulation typical autophagosomes and conjugation LC3 to phosphatidylethanolamine were observed Sp-infected cells as an indication autophagy. Using pneumolysin (PLY) mutant, we successfully demonstrated that PLY is...
To investigate current status of diagnosis and treatment bladder cancer in China.A database was generated by Chinese Bladder Cancer Consortium (CBCC). From January 2007 to December 2012, 14,260 cases from 44 CBCC centers were included. Data diagnosis, pathology collected.The average age 63.5 year-old most patients male (84.3%). The common histologic types urothelial carcinoma (91.4%), adenocarcinoma (1.8%), squamous (1.9%). According 1973 2004 WHO grading system, 42.0%, 41.0%, 17.0% grade 1,...
This study investigated the impact of nursing interventions based on Integrated Theory Health Behavior Change hemodialysis patients. A retrospective analysis 713 patients’ electronic medical records from June 2020 to November 2023 was conducted. Patients were divided into an experimental group, receiving theory, and a control regular care. After 1 month, dialysis indices hospitalization rates compared. Subgroup analyses education level performed. basic information matching, spKt/V values...
Introduction Peritoneal dialysis-associated peritonitis (PDAP) is a serious complication of peritoneal dialysis (PD) patients. The aim this study was to construct risk prediction model for frequent episodes in PDAP Methods This retrospective cohort included patients our center from January 1, 2010 December 31, 2021. constructed by the binary logistic regression. Results We 371 patients, which 235 had single episode and 136 episodes. randomly allocated into training set (296 patients) test...
ABSTRACT Helicobacter pylori , a gram‐negative microaerophilic bacterium, is implicated in broad spectrum of upper gastrointestinal disorders, including chronic gastritis, peptic ulcers, gastric cancer, and even certain extragastric diseases. Its ability to colonize persist within the host driven by complex arsenal colonization virulence factors, underscoring intricate dynamics host–pathogen interactions. The clinical management H. remains challenging, primarily due absence commercially...
Hepatitis B virus (HBV) infection is a major cause of chronic liver disease and hepatocellular carcinoma. Current antiviral therapy does not effectively eradicate HBV further investigations into the mechanisms viral are needed to enable development new therapeutic agents. The sodium-taurocholate cotransporting polypeptide (NTCP) has been identified as functional receptor for entry in cells. However, NTCP sufficient other membrane proteins contribute modulate entry. This study seeks...
<b>Background</b> The objective of the present study was to investigate whether mTOR is involved in cardiac fibrosis evident dilated cardiomyopathy, and rapamycin provides therapeutic potential for fibrosis. <b>Methods</b> Forty-five rats were divided into three groups. Fifteen Adriamycin group underwent 8 weeks treatment (2.5 mg/kg, twice per week; i.v.) induce cardiomyopathy. received (2 day, orally) i.v. simultaneously weeks. untreated served as controls. Cardiac morphology function...
Abstract RNA interference (RNAi) represents a promising strategy for the treatment of HCV infection. However, development an effective system in vivo delivery small interfering (siRNA) to target organ remains formidable challenge. Here, we develop unique nanoparticle platform (VE-DC) composed α-tocopherol (vitamin E) and cholesterol-based cationic liposomes (DOTAP-Chol) systemic siRNAs liver. A HCV-replicable cell line, Huh7.5.1-HCV transient core expressing Huh7.5.1-Core, were constructed...
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are members of the insulin-like factor (IGF) family that play important roles in carcinogenesis. We hypothesized functional polymorphisms IGF-I IGFBP-3 may be associated with risk prostate cancer (PCa) Chinese population. This hospital-based case-control study included 664 PCa patients 702 cancer-free controls. Nine SNPs were genotyped using TaqMan assay. The genetic associations between pathogenesis progression...
Although a variety of drugs have been used to treat the symptoms rheumatoid arthritis (RA), none them are able cure disease. Interferon β (IFN-β) has pleiotropic effects on RA, but whether it can be RA remains globally controversial. Thus, in this study we tested IFN-β patients and collagen antibody-induced (CAIA) model mice. The cytokine auto-antibody expression profiles serum synovial fluid (SF) from were assessed using enzyme-linked immunosorbent assay (ELISA) compared with results...
Many cellular processes are driven by spatially and temporally regulated microRNAs (miRNAs)-dependent signaling events. Over the years, substantial evidence indicates that miRNAs pivotal regulators contribute to initiation development of EV71-related disorders. Importantly, so far, no clinical trial has been undertaken address effect on diseases. In this study, we show EV71 infection results in up-regulation hsa-miR-494-3p levels, EV71-induced impacts PI3K/Akt pathway via targeting PTEN....
Angiogenesis is fundamentally important to the pathogenesis of clear cell renal carcinoma (ccRCC). We investigated association between variations genes related angiogenesis and risk ccRCC. In a case-control study 859 ccRCC patients 1004 cancer-free subjects, we genotyped 24 potentially functional single nucleotide polymorphisms (SNPs) in seven angiogenesis-related (HIF1A, EPAS1, VEGFA, VEGFR1, VEGFR2, VEGFR3 PDGFRB) using TaqMan or Snapshot method. Unconditional logistic regression, adjusted...
Objective Pulmonary fibrosis (PF) is regarded as progressive lung disease. miR-155-5p depletion exerts anti-fibrotic effects in silicotic mice. This study explored the effect and possible mechanism of PF rats, hoping to find a new target for management.
Instructions Peritoneal dialysis associated peritonitis (PDAP) is a major cause of technique failure in peritoneal (PD) patients. The purpose this study to construct risk prediction models by multiple machine learning (ML) algorithms and select the best one predict PDAP patients accurately. Methods This retrospective cohort included maintenance PD our center from January 1, 2010 December 31, 2021. for were constructed based on five ML algorithms: random forest (RF), least absolute shrinkage...
A recent genome-wide association study of renal cell carcinoma (RCC) in European population has identified genetic variants the regions 2p21 (rs7579899), 11q13.3 (rs7105934) and 12q24.31 (rs4765623) conferred susceptibility to RCC. In our study, we assessed whether these polymorphisms are also associated with RCC risk a Chinese population. We genotyped using TaqMan method their associations case–control 710 patients histologically confirmed 760 cancer-free controls. Normal tissues adjacent...
Substantial evidence indicates that β-catenin is a pivotal regulator contributes to the initiation and development of various types diseases. Recently, can be detected in human serum also reported correlated with several disease progression little research. However, very known about relationship between HBV-related liver disease. Serum levels β-catenin, from 77 patients chronic hepatitis B (CHB), 63 associated cirrhosis (HBLC), 61 hepatocellular carcinoma (HCC), 41 healthy HBV carriers...
To evaluate the clinical efficacy and toxicity of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) in patients with esophageal squamous cell carcinoma (ESCC) Chinese population.Patients ESCC, who received SIB-IMRT from September 2011 to January 2013 were retrospectively analyzed. The plans designed deliver primary gross tumor volume at 60-64.4 Gy 28-30 fractions, planning target 50.4-56 fractions. Treatment-related toxicities estimated based on Common Terminology...