A5101678485- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- BRCA gene mutations in cancer
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Cancer-related gene regulation
- Gene expression and cancer classification
- Lung Cancer Treatments and Mutations
- Congenital heart defects research
- Genomics and Chromatin Dynamics
- Healthcare professionals’ stress and burnout
- Telomeres, Telomerase, and Senescence
- 14-3-3 protein interactions
- Pregnancy and preeclampsia studies
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
Nanjing Medical University
2016-2025
Suzhou Traditional Chinese Medicine Hospital
2025
Kunming Medical University
2024
Huazhong University of Science and Technology
2022-2023
Hebei Agricultural University
2023
Union Hospital
2023
Wuhan Union Hospital
2022
Guangdong Provincial Hospital of Traditional Chinese Medicine
2019
State Key Laboratory of Biotherapy
2016
John Wiley & Sons (United States)
2016
Recent evidence indicates that small noncoding RNA molecules known as microRNAs (miRNAs) can function tumor suppressors and oncogenes. Mutation, misexpression, altered mature miRNA processing are implicated in carcinogenesis progression. Because SNPs pre-miRNAs could alter processing, expression, and/or binding to target mRNA, we conducted a systematic survey of common pre-miRNA their surrounding regions evaluated detail the association 4 these with survival individuals non–small cell lung...
Small, noncoding RNA molecules, called microRNAs (miRNAs), are thought to function as either tumor suppressors or oncogenes. Common single-nucleotide polymorphisms (SNPs) in miRNAs may change their property through altering miRNA expression and/or maturation, and thus they have an effect on thousands of target mRNAs, resulting diverse functional consequences. However, it remains largely unknown whether SNPs alter cancer susceptibility. We evaluated the associations selected four (rs2910164,...
Abstract microRNAs (miRNA) are a new class of non-protein-coding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and gene regulators. Recently, we conducted survey common single nucleotide polymorphisms (SNP) miRNA sequences reported that, among four SNPs (rs2910164, rs2292832, rs11614913, rs3746444) pre-miRNAs, rs11614913 miR-196a2 might affect mature miR-196a expression target mRNA-binding activity was significantly associated...
Hox gene clusters play an important role during cardiac septation to valve formation in different species, and the miR-196a-HOXB8-Sonic hedgehog signaling pathway is of particular interest. Recently, we found that a genetic variant rs11614913 miR-196a2 sequence could alter mature miR-196a expression target mRNA binding; this observation led us hypothesize might influence susceptibility sporadic congenital heart disease (CHD). We conducted three-stage case-control study CHD Chinese test our...
The familial aggregation indicated the inheritance of cancer risk. Recent genome‐wide association studies (GWASs) have identified a number common single‐nucleotide polymorphisms (SNPs). Following heritability analyses shown that SNPs could explain moderate amount variance for different phenotypes among Caucasians. However, little information was available in Chinese population. We performed complex trait analysis cancers at nine anatomical sites population (14,629 cases vs . 17,554 controls)...
Channel catfish (Ictalurus spp.) is an economically important species in freshwater aquaculture around the world and occupies a prominent position industry of United States. MicroRNAs (miRNAs) play roles regulation almost every biological process eukaryotes; however, there little information available concerning miRNAs channel catfish. In this study, small-RNA cDNA library was constructed from 10 tissues catfish, Solexa sequencing technology used to perform high-throughput library. A total...
MicroRNAs (miRNA) are a class of small, noncoding RNA molecules involved in diversity cellular functions. Single nucleotide polymorphisms (SNPs) miRNA biosynthesis genes may affect the biogenesis miRNAs and consequently regulation. In this study, we systematically selected 24 functional SNPs located eight key (DROSHA, DGCR8, RAN, DICER, AGO2, GEMIN3, GEMIN4 HIWI) investigated association between these risk breast cancer Chinese population. All were firstly genotyped stage 1 (878 cases 900...
Background Polygenic risk scores (PRSs) have been extensively developed for cancer prediction in European populations, but their effectiveness the Chinese population remains uncertain. Methods and findings We constructed 80 PRSs 13 most common cancers using seven schemes evaluated these 100,219 participants from China Kadoorie Biobank (CKB). The optimal with highest discriminatory ability were used to define genetic risk, site-specific cross-cancer associations assessed. modeled 10-year...
Observational studies suggest that moderate alcohol consumption may be protective for cardiovascular disease, but results biased by confounding and reverse causality. Mendelian randomization, which uses genetic variants as proxies exposures, can minimise these biases therefore strengthen causal inference. Using a variant in the ALDH2 gene associated with consumption, rs671, we performed randomization analysis 1,712 diabetes cases 2,076 controls from Nantong, China. Analyses were using linear...
Abstract Three genome-wide association studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), two which consistently identified tagging single nucleotide polymorphisms (SNPs) around HLA-DQ/DR . In contrast, large multi-centre between HBV genotype, mutations and risk HCC are relatively rare their interactions with host variants even less. We performed a study 1,507 HBV-related cases 1,560 persistent carriers as...
Background and Objectives: Job burnout is prevalent among primary care providers (PCPs) in different countries, the factors that can alleviate these countries have been explored. However, no study has addressed prevalence correlates of job Togolese PCPs. Therefore, we aimed to examine its association with social support psychological capital PCPs Togo. Material Methods: We conducted a cross-sectional Togo from 5 17 November 2020 279 28 peripheral units (PCUs). Participants completed Maslach...
Abstract Background In tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly compromised by drug resistance. Consequently, finding an effective solution to overcome resistance becomes crucial. Reactive oxygen species (ROS) are a group highly active molecules that play important roles in targeted cancer therapy including therapy. this review, we concentrate on ROS-associated mechanisms lethality tumors and...
Dyslipidaemia is a risk factor for abnormal blood glucose. However, studies on the predictive values of lipid markers in prediabetes and diabetes simultaneously are limited. This study aimed to assess associations abilities indices glucose.A sample 7667 participants without were enrolled this cross-sectional conducted 2016, all them classified as having normal glucose tolerance (NGT), or diabetes. Blood glucose, pressure parameters (triglycerides, TG; total cholesterol, TC; high-density...