A5101545102- Noncommutative and Quantum Gravity Theories
- RNA modifications and cancer
- Black Holes and Theoretical Physics
- Cosmology and Gravitation Theories
- Cancer-related gene regulation
- Relativity and Gravitational Theory
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Quantum Electrodynamics and Casimir Effect
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Astrophysical Phenomena and Observations
- Handwritten Text Recognition Techniques
- Experimental and Theoretical Physics Studies
- Caveolin-1 and cellular processes
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Image Processing and 3D Reconstruction
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Quantum Mechanics and Applications
Lanzhou University
2023-2024
Peking University
2023
Huaian First People’s Hospital
2013-2021
Nanjing Medical University
2011-2021
Xuzhou Medical College
2019
Second People’s Hospital of Huai’an
2019
Jiangsu Province Hospital
2011-2018
Abstract In this paper, we study the thermodynamics of Schwarzschild-anti-de Sitter black holes within framework non-commutative geometry. By solving Einstein's equations, derive corrected Schwarzschild-AdS hole with Lorentzian distribution and analyze thermodynamics. Our results confirm that if energy-momentum tensor outside event horizon is related to mass hole, conventional first law will be violated. The criticality reveals undergoes a small hole-large phase transition similar Van der...
Abstract A generation method of new metric in the case static spherically symmetric space-time is derived. Using this approach, we construct a which describes Euler–Heisenberg black hole surrounded by perfect fluid dark matter and investigate its optical thermodynamic properties. We found that radius shadow will increase with effect, more strong diminish light intensity accretion disk generally. Moreover, thermodynamics, when quantum electrodynamic parameter positive, there be critical value...
Abstract We obtained the metric of Schwarzschild-like black hole with loop quantum gravity (LQG) corrections in anti-de Sitter (AdS) space-time, under assumption that cosmological constant is decoupled LQG. investigated its thermodynamics, including equation state, criticality, heat capacity, and Gibbs free energy. The $$P-v$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>P</mml:mi> <mml:mo>-</mml:mo> <mml:mi>v</mml:mi> </mml:mrow> </mml:math> graph was...
Long noncoding RNAs (lncRNAs) are emerging as key regulators governing fundamental biological processes, and their disorder expression involves in the development of several human cancers. MIR31HG, an lncRNA located 9p21.3 2166 bp length, has been found to be upregulated breast cancer contributes cell proliferation invasion. However, pattern function MIR31HG gastric still not well documented. In this study, we that is decreased tissues associated with larger tumor size advanced pathological...
Abstract Three genome-wide association studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), two which consistently identified tagging single nucleotide polymorphisms (SNPs) around HLA-DQ/DR . In contrast, large multi-centre between HBV genotype, mutations and risk HCC are relatively rare their interactions with host variants even less. We performed a study 1,507 HBV-related cases 1,560 persistent carriers as...
The Schwarzschild black hole in the Cold Dark Matter (CDM) halo is studied, and radiation laws of thin accretion disk near are discussed summarized. orbits light around also calculated. Additionally, using Novikov–Thorne model’s intensity function disk, it possible to solve for shadow created by as well observed luminosity disk.
Autotaxin (ATX) possesses lysophospholipase D (lyso PLD) activity, which converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in angiogenesis, chronic inflammation and tumor progression. Osteopontin (OPN) is an important chemokine involved the survival, proliferation, migration, invasion metastasis of gastric cancer cells. focus present study was to investigate relationship between OPN. In comparison with non-treated cells,...
Abstract The interaction between Axin and DVL2 is critical for the breaking down of beta‐catenin destruction complex activation Wnt/beta‐catenin cascade. However, this biological process remains poorly understood. In present study, TM4SF1 was identified as interacting partner positively regulated signalling by strengthening DVL2‐Axin interaction. expression levels were elevated in hepatocellular carcinoma (HCC) induced Kras signalling. overexpression promoted growth motility HCC cells,...
Backgrounds: Microfibril-associated protein 2 (MFAP2) is an extracellular matrix that regulates the function of microfibrils by interacting with fibrillin. MFAP2 has been reported to play important role in metabolic diseases and shown be significantly overexpressed head neck squamous cell carcinoma Hepatocellular (HCC). However, molecular prognostic value have never HCC or other tumors. Methods: In present study, expression characteristics HCC, its influence on development as well potential...
Circular RNA (circRNA) affects the occurrence and development of human cancers, but specific mechanism hepatocellular carcinoma (HCC) has not yet been fully understood. CircRNAs were determined by circRNA array analysis quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell viability, migration, invasion, other indicators used for cell function analysis. Knockdown overexpression techniques to explore circCORO1C in HCC sequencing, qRT-PCR, western blot, methods. Among...
This study aimed to investigate the relationship between expression of microRNA (miR)-181b, protein inhibitor activated STAT3 (PIAS3) and STAT3, examine function miR-181b/PIAS3/STAT3 axis on Warburg effect xenograft tumour growth colon cancer. Moreover, a positive feedback loop miR-181b that regulated in cancer was explored. A luciferase reporter assay used identify whether PIAS3 direct target miR-181b. The gain-of-function loss-of-function experiments were performed HCT 116 cells cancer, as...
Glycogen synthase kinase-3β (GSK3β) expression and activity are upregulated in pancreatic cancer tissues. In our previous study, we found that stromal cell-derived factor-1/ chemokine receptor C-X-C motif 4 (SDF-1α/CXCR4) matrix metalloproteinase 2 (MMP-2) promoted invasion PANC1 SW-1990 cells by activating p38 mitogen-activated protein kinase (p38 MAPK). Additionally, inhibition of GSK3β reduced MMP-2 secretion. To investigate the molecular mechanism tissues, created stable up-regulation...
Paired-box family member PAX8 encodes a transcription factor that has role in cell differentiation and growth may participate the prognosis of hepatocellular carcinoma (HCC). By bioinformatics analysis, we identified several single nucleotide polymorphisms (SNPs) within newly long non-coding RNA (lncRNA) AC016683.6 as expression quantitative trait loci (eQTLs) for PAX8. Hence, hypothesized PAX8eQTLs lncRNA influence HCC prognosis. We then performed case-only study to assess association...
The cytotoxic T-lymphocyte antigen 4 (CTLA4) gene polymorphisms have been shown to be associated with the risk of primary biliary cirrhosis (PBC). study aimed confirm associations CTLA4 PBC and patients' quality life in Chinese population.A total 312 female patients from Han population were included as case, 375 age-matched healthy volunteers control. Four single nucleotide (SNPs) including rs231775, rs3087243, rs231725, rs5742909 genotyped. differences genotype allele distributions between...