A5000196513- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Vibrio bacteria research studies
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- HIV, Drug Use, Sexual Risk
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Climate Change and Health Impacts
- Estrogen and related hormone effects
- Endoplasmic Reticulum Stress and Disease
- HIV/AIDS Research and Interventions
- Landslides and related hazards
- Viral Infections and Outbreaks Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Circular RNAs in diseases
- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
Jiangsu Provincial Center for Disease Control and Prevention
2016-2025
Nanjing Medical University
2005-2025
Bioscience (China)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Chinese Center For Disease Control and Prevention
2013-2015
Centers for Disease Control and Prevention
2011-2012
Second Affiliated Hospital of Zhejiang University
2009
Huazhong University of Science and Technology
2005
Zero to Three
2005
<h3>Importance</h3> Hepatitis B virus (HBV) has been identified as a major risk factor for hepatocellular carcinoma. However, the associations between HBV infection and other cancer types are not well understood. <h3>Objective</h3> To assess chronic of all types. <h3>Design, Setting, Participants</h3> This population-based study involved 3 cohorts in China. The China Kadoorie Biobank (CKB) prospective cohort study, conducted June 2004 July 2008, used dipstick assay detection serum hepatitis...
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel loci associated with HBV–related HCC and replicate the previously reported association, we performed a large three-stage GWAS in Han Chinese population. 523,663 autosomal SNPs 1,538 HBV–positive patients 1,465 chronic HBV carriers were genotyped discovery stage. Top candidate initial validation samples of...
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) HLA-DQ (rs2856718 rs7453920) were associated with chronic hepatitis B virus (HBV) infection Japanese populations. More than 75% of hepatocellular carcinoma (HCC) patients are attributable to persistent (HBV), especially China. We genotyped these SNPs 1,300 HBV-positive HCC patients, 1,344 HBV carriers, persons natural clearance from...
Background Recently, several studies have demonstrated that two long non-coding RNAs (lncRNAs), HULC and MALAT1, may participate in hepatocellular carcinoma (HCC) development progression. However, genetic variations the lncRNAs their associations with HCC susceptibility not been reported. In this study, we hypothesized single nucleotide polymorphisms (SNPs) MALAT1 contribute to risk. Methods We conducted a case-control study genotyped SNPs, rs7763881 rs619586 1300 HBV positive patients, 1344...
Background MiR-106b-25 cluster, hosted in intron 13 of MCM7, may play integral roles diverse processes including immune response and tumorigenesis. A single nucleotide polymorphism (SNP), rs999885, is located the promoter region MCM7. Methods We performed a case-control study 1300 HBV-positive hepatocellular carcinoma (HCC) cases, 1344 HBV persistent carriers subjects with natural clearance to test association between rs999885 risk infection HCC. also investigated genotype-expression...
Although non-alcoholic fatty liver disease (NAFLD) has been studied extensively, the potential risk factors for NAFLD among chronic hepatitis B (CHB) patients have not fully known.A population-based cohort of adult CHB without a history alcohol drinking or were recruited and followed up from October 2012 to January 2015 in Jiangsu province, China. Using Cox proportional hazards regression model, including viral metabolic evaluated.Two thousand three hundred ninety-three (mean age 50.7 ± 13.2...
Genotyping of hepatitis B virus (HBV) is important for tracking HBV infections, prognosticating the development severe liver disease, and predicting outcomes therapy. Current genotyping methods can be laborious costly rely on subjective data interpretation. To identify less expensive but equally reliable alternatives, we compared "gold standard" sequencing to a novel mass spectrometry approach. Sera from individuals with acute or chronic infection (n = 756), representing all genotypes, were...
Zinc ribbon domain containing 1 (ZNRD1), cloned from human leukocyte antigen (HLA) region, may play integral roles in diverse processes including immune response against HBV infection and hepatocarcinogenesis. ZNRD1‐AS1 (ZNRD1 antisense RNA 1) be an important regulator of ZNRD1. By bioinformatics analyses, we identified that several single nucleotide polymorphisms (SNPs) expression quantitative trait loci (eQTLs) for In this study, hypothesized these eQTLs SNPs influence both chronic...
Abstract Three genome-wide association studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), two which consistently identified tagging single nucleotide polymorphisms (SNPs) around HLA-DQ/DR . In contrast, large multi-centre between HBV genotype, mutations and risk HCC are relatively rare their interactions with host variants even less. We performed a study 1,507 HBV-related cases 1,560 persistent carriers as...
Abstract Cyclooxygenase (COX), the rate-limiting enzyme in prostaglandins (PG) synthesis, exists at least two isoforms, COX-1 and COX-2. COX-2 plays an important role carcinogenesis, overexpression may increase proliferation, inhibit apoptosis, enhance invasiveness of breast cancer cells. Polymorphisms regulatory regions gene influence function and/or expression contribute to interindividual variability susceptibility cancer. In this study three variants (−1195G/A −765G/C promoter 8473C/T...
Abstract Genetic variations in miRNA processing genes may affect the biogenesis of miRNA, hence risk HBV infection and hepatocellular carcinoma (HCC) development. In present study, we hypothesized that potentially functional polymorphisms 3′‐untranslated region (UTR) might contribute to susceptibility HCC To test hypothesis, genotyped three selected SNPs (rs1057035 DICER1 , rs3803012 RAN rs10773771 PIWIL1 ) a case–control study 1300 HBV‐positive cancer cases, 1344 persistent carriers,...
Several genome-wide association studies (GWAS) have demonstrated the between genetic variants in major histocompatibility complex (MHC) region and chronic hepatitis B (CHB) virus infection, but it is still unknown about disease-causing loci potential mechanisms owing to complicated linkage disequilibrium for this region. To systematically characterize MHC variations relation CHB we fine mapped on our existing GWAS data with SNP2HLA taken Pan-Asian panel as reference finally identified four...
Individuals fail to elicit protective antibody after hepatitis B vaccination remain at risk for virus infection. Analysis of the transcriptome peripheral blood mononuclear cells (PBMCs) is essential elucidate characteristics gene expression in non-responders. In this study, we enrolled seven responders who had received three injections and non-responders six vaccine before. All participants were then vaccinated with a three-dose boost regimen. Microarray analysis Luminex assay applied...
p53-binding protein 1 (P53BP1), a central transducer of DNA-damage signals to p53, is required for both intra-S-phase and G 2 -M checkpoints, suggesting that these two proteins may work together in the p53-mediated transcriptional activation DNA damage-repair signaling pathways. Because region 53BP1 maps C-terminal BRCT domains, which are homologous those found breast cancer BRCA1, we hypothesized genetic variation P53BP1 p53 contribute predisposition. To test this hypothesis, simultaneously...
Abstract p21 Cip1 and p27 Kip1 are cyclin‐dependent kinase inhibitors, which can arrest cell proliferation serve as tumor suppressors. Reduced protein expression of was frequently observed in a subset cancers, including breast cancer. In this study, we hypothesized that genetic variants CDKN1A (encode for ) CDKN1B may modulate the risk To test hypothesis, evaluated associations polymorphisms Ser31Arg C+20T C−79T Gly109Val , well their combinations, with cancer case‐control study 368 cases...