A5101610378- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Metastasis and carcinoma case studies
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Breast Lesions and Carcinomas
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Innovations in Medical Education
- Lymphatic Disorders and Treatments
- Cloud Computing and Remote Desktop Technologies
- Burn Injury Management and Outcomes
- Marine and coastal ecosystems
- Thermal Regulation in Medicine
- Breast Implant and Reconstruction
- Skin and Cellular Biology Research
- Infectious Diseases and Mycology
- Industrial Technology and Control Systems
- Histone Deacetylase Inhibitors Research
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Vascular Malformations and Hemangiomas
Nanjing Medical University
2014-2024
Jiangsu Provincial Academy of Environmental Science
2016-2024
Jiangsu Province Hospital
2004-2018
Henan Polytechnic University
2011
Nanyang Institute of Technology
2001-2009
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTChina's Soil Pollution Control: Choices and ChallengesChangsheng Qu‡, Wei Shi*†, Jing Guo†, Binbin Fang‡, Shui Wang‡, John P. Giesy§∥†, Peter E. Holm⊥View Author Information† State Key Laboratory of Control Resource Reuse, School the Environment, Nanjing University, Nanjing, China‡ Institute Environment Environmental Engineering, Jiangsu Academy Sciences, China§ Department Biomedical Veterinary Biosciences Toxicology Centre, University...
Minimally invasive therapies, such as microwave ablation (MWA), are widely used for the treatment of solid tumors. Previous studies suggest that MWA is feasible small breast cancer, and thermal may induce adaptive antitumor immunity. However, induced immune responses mostly weak, immunomodulation effects in cancer unclear. Immunostimulant OK-432 can tumor-specific T-cell augment immunity by MWA. We treated 4T1 bearing BALB/c mice with MWA, OK-432, plus or left without treatment. Survival...
Metastasis is the major cause of cancer-related death, and lymph node most common site metastasis in breast cancer. However, alterations that happen tumor-draining nodes (TDLNs) to form a premetastatic microenvironment are largely unknown. Here, we first report dynamic changes size immune status TDLNs before With progression tumor, TDLN enlarged immune-activated at early stage contains specific antitumor immunity against metastasis. The then contracted immunosuppressed late finally getting...
<h3>Importance</h3> There is a lack of studies exploring whether the survival patients with distant lymph node metastases (DLNM) different from that ipsilateral supraclavicular (ISLM) and other stage IV breast cancer. <h3>Objective</h3> To assess DLNM cancer vs ISLM <h3>Design, Setting, Participants</h3> This cohort study included 2033 diagnosed between January 1, 2010, December 31, 2014, Surveillance, Epidemiology End Results registries database. Three groups were included: (1) without any...
Abstract p21 Cip1 and p27 Kip1 are cyclin‐dependent kinase inhibitors, which can arrest cell proliferation serve as tumor suppressors. Reduced protein expression of was frequently observed in a subset cancers, including breast cancer. In this study, we hypothesized that genetic variants CDKN1A (encode for ) CDKN1B may modulate the risk To test hypothesis, evaluated associations polymorphisms Ser31Arg C+20T C−79T Gly109Val , well their combinations, with cancer case‐control study 368 cases...
Oncogene c‐Src has been found to be a potential target for the treatment of triple‐negative breast cancer ( TNBC ). However, therapeutic effects inhibitor on patients are controversial compared those cell lines. The molecular mechanisms inhibitory remain unclear. Herein, we showed that specific inhibitor, PP 2, was effective in inhibiting phosphorylation 4 lines: T‐47D, SK ‐ BR ‐3, SUM 1315 MO and MDA MB ‐231, regardless hormone receptors human epidermal growth factor receptor 2 HER 2)...
Background Previous studies provide an ambiguous picture of creatine kinase (CK) expression and activities in malignancy. The aim this study was to investigate the role serum CK level breast cancer patients. Patients Methods 823 female patients diagnosed with were consecutively recruited as cases, age-match benign disease selected controls. Serum analyzed by commercially available standardized methods. Results significantly associated (P = 0.005) subtypes cancer, including diameter>2 cm...
Aldehyde dehydrogenase 1 (ALDH1) is an important marker of tumor-initiating cells. We aimed to investigate ALDH1 expression in benign breast disease and human cancer different histologic stages. Immunohistochemical staining was applied 21 cases with diseases, 47 ductal carcinoma situ (DCIS) cases, 62 diagnosed invasive extensive intraductal component (EIC), 58 without EIC. expressed tumor cells 61.0 % 164 which higher than that (3/21) (P < 0.001). Of these 167 a significantly rate (54/58)...
BACKGROUND:Epithelial to mesenchymal transition (EMT) contributes metastases in various types of tumors, and is also the key step breast cancer metastatic cascade. In our previous study, a mouse model containing human-derived normal tissue was established allowed EMT/MET process human cells be mimicked humanized mammary microenvironment. MATERIAL AND METHODS:Two-dimensional electrophoresis (2-DE) mass spectrometry were used detect different proteins between parental MDA-MB-231 its variant...
Cancer/testis antigen (CTA) SSX2, which is silent in most normal adult tissues and expressed various malignant tumors, has been identified for decades. Expression of SSX tumors associated with advanced stages worse patient prognosis. However, little known about its role breast cancer. The SSX2 expression plasmid constructed was stably transfected into the cancer cell line MCF-7. influence on MCF-7 cells assessed using MTT assay, flow cytometry, transwell invasion assay vivo tumorigenicity...
Circulating tumor cells (CTCs) intravasate into the bloodstream throughout early cancer stages, promoting metastasis. The microenvironment plays a crucial role in disease progression and outcome. aim of this prospective study was to investigate associations intratumoral stromal tumor-infiltrating lymphocytes (TILs) with CTCs among patients receiving neoadjuvant chemotherapy (NAC).We analyzed 30 primary breast before after NAC. numbers TILs (iTILs) (sTILs) from pre-NAC formalin-fixed...
Locoregional recurrent breast cancers have a poor prognosis. Little is known about the prognostic impact of immune microenvironment, and tertiary lymphoid structures (TLSs) in particular not been reported. Thus, we aimed to characterize microenvironment locoregional tumors investigate its relationship with
太湖是一个大型浅水湖泊,湖湾、沿岸及湖心等区域受地形影响,湖流结构及水土界面水力要素均有显著差异.针对目前对不同湖区底泥再悬浮规律差异性研究的缺失,本研究选取了3个具有代表性的点采集太湖底泥,采用矩形水槽开展底泥再悬浮模拟实验,并结合太湖二维水量水质模型及太湖全年实测数据,建立了不同湖区底泥再悬浮通量与风速之间的定量关系;通过室内静沉降实验,得到了静沉降通量与风速的相关关系;最后将底泥再悬浮实验结果参数化应用于太湖二维水量水质模型中,并对底泥悬浮沉降过程进行分解和概化,估算太湖全年内源释放量.结果表明:太湖每日的内源释放量受风速影响显著,和风速变化趋势较为接近,太湖全年进入水体的净底泥量有47.81×10<sup>4</sup> t,夏季最大,冬季次之;就营养物质释放量而言,COD约为2.06×10<sup>4</sup> t、总氮约为1149.05 t、总磷约为564.35 t,其中秋季营养物质释放量最小,夏季最大.;As a large shallow lake, Lake Taihu exhibits significant differences in flow...
<title>Abstract</title> Chinese chemical companies often cluster in specific regions, leading to concentrated emissions of various chemicals and pollutants, which poses significant risks ecosystems human health. Water samples were collected from the rivers near industrial park (CIP) Jiangsu Province, China, utilized suspect screening identify pollutants. This study aimed examine correlation between these pollutants those detected effluent or wastewater treatment plants (WWTPs) within CIP,...
Abstract Background: Breast cancer is the most common malignant tumors worldwide and leading cause of death among female. Microproteins, a kind protein which nearly 100 amino acids in length, have been demonstrated to play important roles biology disease. Here, we present potential microprotein TRPC5 opposite strand (TRPC5OS), may exert function breast progression. Methods: Differential expression TRPC5OS was measured via Immunohistochemistry (IHC) samples quantitative real-time PCR...
Abstract Background: Tumors are infiltrated by inflammatory cells (e.g. macrophages, B and T lymphocytes), which may promote tumor growth invasion. However, the clinical correlation between hematogenous metastasis relative amount of is still unknown. Methods: The prevalence circulating (CTC) in peripheral blood 133 breast cancer patients was detected a multimarker comprised cytokeratin 19 (CK19), small epithelial mucin (SBEM) human mammaglobin (hMAM) real time quantitative RT-PCR (QPCR)...
Objective To investigate the correlation between infiltration of CD8 + T cells as well regulatory (Tregs) in tumor microenvironment and clinicopathological factors breast cancer.Methods Infiltration +T Tregs bed tissue surrounding was assessed by using immunohistochemistry 82 cases cancer,and its associations with features were analyzed.Infiltration 20 benign disease control.Results Infiltrating cancer more abundant than those (26.53 ±6.39 vs.4.05 ±2.04; 12.49 ±5.81 vs.0.81 ± 1.16).Breast...