A5011538072- Cancer Immunotherapy and Biomarkers
- Metamaterials and Metasurfaces Applications
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Advanced Antenna and Metasurface Technologies
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Head and Neck Cancer Studies
- Liver physiology and pathology
- MicroRNA in disease regulation
- Process Optimization and Integration
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Breast Lesions and Carcinomas
- Effects of Radiation Exposure
Zhejiang University
2019-2025
Zhejiang University-University of Edinburgh Institute
2022-2025
Zhejiang University of Science and Technology
2022-2025
Jinhua Academy of Agricultural Sciences
2022-2025
Jiangjin Central Hospital
2025
Chongqing University
2025
State Key Laboratory of Modern Optical Instruments
2022-2024
Nanjing Medical University
2005-2024
Quzhou University
2024
Shaoxing People's Hospital
2023-2024
Pyroptosis has been reported to improve the immunosuppressive tumor microenvironment and may be a strategy enhance osteosarcoma treatment. The extent which modulation of mitochondria could induce pyroptosis immunotherapy not characterized. We synthesized mitochondria-targeting polymer micelle (OPDEA-PDCA), in poly[2-(N-oxide-N,N-diethylamino)ethyl methacrylate] (OPDEA) was used target conjugated dichloroacetate (DCA) inhibit pyruvate dehydrogenase kinase 1 (PDHK1). This conjugate induced...
The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation immune tolerance mechanisms in the microenvironment and a new therapeutic strategy. Clearance apoptotic cells by phagocytes, process termed "efferocytosis," is ubiquitous tumors mediates suppression innate inflammatory response. Considering massive infiltrated macrophages osteosarcoma, efferocytosis probably serves as potential target, but rarely studied osteosarcoma. Here, we verified M2 polarization...
Compelling evidence suggests that the interaction between electromagnetic metasurfaces and deep learning gives rise to proliferation of intelligent in past decade.In general, offers a transformative force reform design working style metasurfaces.Most inverse-design literature announces that, given user-defined input, pre-trained models can quickly output metasurface candidates with high fidelity.However, they largely ignore an important fact, is, practical input is always semi-known.In this...
Adoptive cell therapy (ACT) for cancers using autologous tumor-infiltrating lymphocytes (TILs) can induce immune responses and antitumor activity in metastatic melanoma patients. Here, we aimed to assess the safety of ACT expanded TILs following concurrent chemoradiotherapy (CCRT) patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Twenty-three newly diagnosed, NPC were enrolled, whom 20 received a single-dose TIL infusion CCRT. All treated assessed toxicity, survival...
Background Dysbiosis commonly occurs in pancreatic cancer, but its specific characteristics and interactions with cancer remain obscure. Materials methods The 16S rRNA sequencing method was used to analyze multisite (oral gut) microbiota of chronic pancreatitis, healthy controls. Differential analysis identify the cancer-associated genera pathways. A random forest algorithm adopted establish diagnostic models for cancer. Results pancreatitis group exhibited lowest microbial diversity, while...
Immune checkpoint blockade has shown low response rates for advanced breast cancer, and combination strategies are needed. Microwave ablation (MWA) may be a trigger of antitumor immunity. This window-of-opportunity trial (ClinicalTrials.gov: NCT04805736) was conducted to determine the safety feasibility preoperative camrelizumab (an anti-PD-1 antibody) combined with MWA in treatment early-stage cancer.
Schizophrenia is a severe psychological disorder. The current diagnosis mainly relies on clinical symptoms and lacks laboratory evidence, which makes it very difficult to make an accurate especially at early stage. Plasma protein profiles of schizophrenia patients were obtained compared with healthy controls using 4D-DIA proteomics technology. Furthermore, 79 DEPs identified between controls. GO functional analysis indicated that predominantly associated responses toxic substances platelet...
Chromatin is a highly dynamic environment playing critical roles in the regulation of gene expression. Modifications to proteins which make up nucleosome core have been shown profound regulatory effects on Of these, best known modification acetylation histone tails. Two enzymes regulate these processes, deacetylases and acetyltransferases. Both dysregulated functions certain tumors. Several classes deacetylase inhibitors isolated are currently undergoing evaluation as potential therapeutic...
Abstract Background Our recent cDNA microarray data showed that centromere protein F (CENP-F) is significantly upregulated in primary cultured nasopharyngeal carcinoma (NPC) tumor cells compared with normal epithelial cells. The goal of this study was to further investigate the levels CENP-F expression NPC cell lines and tissues clarify clinical significance as well potential therapeutic implications expression. Methods Real-time RT-PCR western blotting were used examine (NPEC), immortalized...
CD8+ effector cells often have an antitumor function in patients with cancer. However, CD8+Foxp3+ regulatory T (Tcregs) and interleukin (IL)-17-producing (Tc17 cells) also derive from the cell lineage. Their role response remains largely unknown. In present study, we aimed to investigate distribution, characterization, generation of Tcregs Tc17 NPC patients. Peripheral blood tumor biopsy tissues 21 newly diagnosed nasopharyngeal carcinoma (NPC) were collected, along peripheral healthy...
Abstract Intelligent metasurfaces, as the next‐generation of have emerged a versatile artificial electromagnetic (EM) medium capable adaptively manipulating wave‐matter interactions, especially in construction EM space integration and analogy wave‐based neural networks. However, current computational landscape for intelligent metasurfaces relies either on time‐consuming full‐wave numerical simulations with excessive complexity or application‐limited physical models that are difficult to...
Background: Temozolomide (TMZ) is a first-line chemotherapeutic agent for gliomas. However, its efficacy limited by drug resistance. Platycodin D (PD) exhibits notable anti-glioma activity The objective of this study was to investigate the potential PD augment glioma sensitivity TMZ and underlying mechanisms. Methods: Cell viability proliferation were assessed using CCK-8 clonogenic assays, respectively, while flow cytometry used detect apoptosis. migration invasion Transwell assays. Western...
ABSTRACT Inspired by the concept of superscattering in optics, we for first time theoretically predict and experimentally demonstrate phenomenon water waves. The subwavelength superscatterer is constructed multi-layered concentric cylinders with an inhomogeneous depth profile. breaks long-held single-channel scattering limit several times thus significantly enhances total strength. underlying mechanism originates from near degeneracy resonances multiple channels. We fabricate prototype...